What you should know about PR3-ANCA

Alan Wiik

What you should know about PR3-ANCA: Conformational requirements of proteinase 3 (PR3) for enzymatic activity and recognition by PR3-ANCA

The neutrophil azurophil granule constituent proteinase 3 (PR3) is the principal antigen for anti-neutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosis. The conformation of the mature PR3 enzyme...

Authors: Ulrich Specks

Citation: Arthritis Research & Therapy 2000 2:263

Content type: Review Published on: 12 June 2000
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What you should know about PR3-ANCA: Evidence for the role of T cells in the pathogenesis of systemic vasculitis

The pathogenesis of systemic vasculitis is complex and is likely to involve many mechanisms. There is a growing body of evidence that T cells may contribute to the pathogenesis of anti-neutrophil cytoplasmic a...

Authors: Abigail R Clayton and Caroline OS Savage

Citation: Arthritis Research & Therapy 2000 2:260

Content type: Review Published on: 12 June 2000
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What you should know about PR3-ANCA: Structural aspects of antibodies to proteinase 3 (PR3)

Reactive antigenic epitopes on presumed autoantigens of biologic interest have been examined by many researchers. The central third complementarity-determining region (CDR3) residues of a human monoclonal anti...

Authors: Elisabeth Peen and Williams Ralph C Jr

Citation: Arthritis Research & Therapy 2000 2:255

Content type: Review Published on: 12 June 2000
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What you should know about PR3-ANCA: An introduction

Anti-neutrophil cytoplasmic antibodies (ANCA) have become important diagnostic markers of small vessel vasculitides characterized by focal necrotizing lesions of vessel walls and accumulation of lymphocytes an...

Authors: Allan Wiik

Citation: Arthritis Research & Therapy 2000 2:252

Content type: Review Published on: 12 June 2000
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What you should know about PR3-ANCA

What you should know about PR3-ANCA: Conformational requirements of proteinase 3 (PR3) for enzymatic activity and recognition by PR3-ANCA

What you should know about PR3-ANCA: Evidence for the role of T cells in the pathogenesis of systemic vasculitis

What you should know about PR3-ANCA: Structural aspects of antibodies to proteinase 3 (PR3)

What you should know about PR3-ANCA: An introduction