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Cells of the synovium in rheumatoid arthritis

Gary Firestein

  1. The multitude and abundance of macrophage-derived mediators in rheumatoid arthritis and their paracrine/autocrine effects identify macrophages as local and systemic amplifiers of disease. Although uncovering t...

    Authors: Raimund W Kinne, Bruno Stuhlmüller and Gerd-R Burmester
    Citation: Arthritis Research & Therapy 2007 9:224
  2. For some time synovial fibroblasts have been regarded simply as innocent synovial cells, mainly responsible for synovial homeostasis. During the past decade, however, a body of evidence has accumulated illustr...

    Authors: Ulf Müller-Ladner, Caroline Ospelt, Steffen Gay, Oliver Distler and Thomas Pap
    Citation: Arthritis Research & Therapy 2007 9:223
  3. Rheumatoid arthritis (RA) is one of the inflammatory joint diseases in a heterogeneous group of disorders that share features of destruction of the extracellular matrices of articular cartilage and bone. The u...

    Authors: Miguel Otero and Mary B Goldring
    Citation: Arthritis Research & Therapy 2007 9:220

    The Erratum to this article has been published in Arthritis Research & Therapy 2008 10:401

  4. Dendritic cells are the major antigen-presenting and antigen-priming cells of the immune system. We review the antigen-presenting and proinflammatory roles played by dendritic cells in the initiation of rheuma...

    Authors: Viviana Lutzky, Suad Hannawi and Ranjeny Thomas
    Citation: Arthritis Research & Therapy 2007 9:219
  5. There is significant evidence arising from experimental models that autoantibodies play a key role in the pathogenesis of inflammatory arthritis. In addition to autoantibody production, B cells efficiently pre...

    Authors: Claudia Mauri and Michael R Ehrenstein
    Citation: Arthritis Research & Therapy 2007 9:205
  6. Osteoclasts are multinucleated cells of hematopoietic origin and are the primary bone resorbing cells. Numerous osteoclasts are found within the synovial tissue at sites adjacent to bone, creating resorption p...

    Authors: Georg Schett
    Citation: Arthritis Research & Therapy 2007 9:203
  7. Recent findings have substantiated the importance of T lymphocytes to the pathogenesis of rheumatoid arthritis (RA). Here, we review emerging data regarding genetic predisposition, spontaneous animal models of...

    Authors: Steven K Lundy, Sujata Sarkar, Laura A Tesmer and David A Fox
    Citation: Arthritis Research & Therapy 2007 9:202