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Cells of the synovium in rheumatoid arthritis

Gary Firestein

  1. Content type: Review

    The multitude and abundance of macrophage-derived mediators in rheumatoid arthritis and their paracrine/autocrine effects identify macrophages as local and systemic amplifiers of disease. Although uncovering t...

    Authors: Raimund W Kinne, Bruno Stuhlmüller and Gerd-R Burmester

    Citation: Arthritis Research & Therapy 2007 9:224

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  2. Content type: Review

    For some time synovial fibroblasts have been regarded simply as innocent synovial cells, mainly responsible for synovial homeostasis. During the past decade, however, a body of evidence has accumulated illustr...

    Authors: Ulf Müller-Ladner, Caroline Ospelt, Steffen Gay, Oliver Distler and Thomas Pap

    Citation: Arthritis Research & Therapy 2007 9:223

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  3. Content type: Review

    Rheumatoid arthritis (RA) is one of the inflammatory joint diseases in a heterogeneous group of disorders that share features of destruction of the extracellular matrices of articular cartilage and bone. The u...

    Authors: Miguel Otero and Mary B Goldring

    Citation: Arthritis Research & Therapy 2007 9:220

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    The Erratum to this article has been published in Arthritis Research & Therapy 2008 10:401

  4. Content type: Review

    Dendritic cells are the major antigen-presenting and antigen-priming cells of the immune system. We review the antigen-presenting and proinflammatory roles played by dendritic cells in the initiation of rheuma...

    Authors: Viviana Lutzky, Suad Hannawi and Ranjeny Thomas

    Citation: Arthritis Research & Therapy 2007 9:219

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  5. Content type: Review

    There is significant evidence arising from experimental models that autoantibodies play a key role in the pathogenesis of inflammatory arthritis. In addition to autoantibody production, B cells efficiently pre...

    Authors: Claudia Mauri and Michael R Ehrenstein

    Citation: Arthritis Research & Therapy 2007 9:205

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  6. Content type: Review

    Osteoclasts are multinucleated cells of hematopoietic origin and are the primary bone resorbing cells. Numerous osteoclasts are found within the synovial tissue at sites adjacent to bone, creating resorption p...

    Authors: Georg Schett

    Citation: Arthritis Research & Therapy 2007 9:203

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  7. Content type: Review

    Recent findings have substantiated the importance of T lymphocytes to the pathogenesis of rheumatoid arthritis (RA). Here, we review emerging data regarding genetic predisposition, spontaneous animal models of...

    Authors: Steven K Lundy, Sujata Sarkar, Laura A Tesmer and David A Fox

    Citation: Arthritis Research & Therapy 2007 9:202

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