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Recombinant production of new antimicrobials in microbial cell factories

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In the last decades the incidence of antibiotic-resistant bacteria affecting both human and animal medicine has exponentially increased. To tackle the burden of antimicrobial resistances (AMRs) pathogens, it is necessary to develop new antimicrobial drugs with novel modes of action. In many cases, products with antimicrobial properties have been obtained by chemical synthesis but it is a costly process and has certain limitations. In this context, the recombinant production of antimicrobial molecules from different origin appears as an appealing strategy. Among recombinant production systems, microorganisms are widely used. However, frequently antimicrobial molecules are difficult to produce, being necessary to develop new strategies for their production.
Thus, in this collection of Microbial Cell Factories we cover research towards the production, purification and characterization of novel antimicrobial molecules as alternatives to antibiotics using microbial cell factories as expression systems.

Editors: Drs Elena Garcia and Anna Aris, Institute for Food and Agricultural Research and Technology, Spain
 

  1. The antimicrobial resistance crisis calls for the discovery and production of new antimicrobials. Host defense peptides (HDPs) are small proteins with potent antibacterial and immunomodulatory activities that ...

    Authors: Ramon Roca-Pinilla, Leszek Lisowski, Anna Arís and Elena Garcia-Fruitós
    Citation: Microbial Cell Factories 2022 21:267
    Content type: Review Published on:

  2. Due to the detrimental effects of chemical preservatives, there has been an increasing demand for safer, healthier and natural bio-preservatives. Bacteriocins have attracted increasing interest because of thei...

    Authors: Xiaofeng Zhang, Nie Xin, Zhaolu Zhu, Xudong Li, Dadong Dai, Chunmei Pan, Donghai Peng and Ming Sun
    Citation: Microbial Cell Factories 2022 21:194
    Content type: Research Published on:

  3.  Salmonella is a common foodborne pathogen, which can cause intestinal diseases. In the last decades, the overuse of antibiotics has led to a pandemic of drug-resistant bacterial infections. To tackle the burden ...

    Authors: Shuhang Zhang, Yan Chang, Qing Zhang, Yingbo Yuan, Qingsheng Qi and Xuemei Lu
    Citation: Microbial Cell Factories 2022 21:171
    Content type: Research Published on:

  4. Microbial derived-surfactants display low eco-toxicity, diverse functionality, high biodegradability, high specificity, and stability under extreme conditions. Sophorolipids are emerging as key biosurfactants ...

    Authors: Achmad Rifky Alfian, Kwanrutai Watchaputi, Chayaphathra Sooklim and Nitnipa Soontorngun
    Citation: Microbial Cell Factories 2022 21:163
    Content type: Research Published on:

  5. Microbial infection and cancer are two leading causes of global mortality. Discovering and developing new therapeutics with better specificity having minimal side-effects and no drug resistance are of an immen...

    Authors: Atefeh Parchebafi, Farzaneh Tamanaee, Hassan Ehteram, Ejaz Ahmad, Hossein Nikzad and Hamed Haddad Kashani
    Citation: Microbial Cell Factories 2022 21:118
    Content type: Review Published on:

  6. Subtilin is a peptide antibiotic (lantibiotic) natively produced by Bacillus subtilis ATCC6633. It is encoded in a gene cluster spaBTCSIFEGRK (spa-locus) consisting of four transcriptional units: spaS (subtilin p...

    Authors: Qian Zhang, Carolin M. Kobras, Susanne Gebhard, Thorsten Mascher and Diana Wolf
    Citation: Microbial Cell Factories 2022 21:57
    Content type: Research Published on:

  7. Tuberculosis currently stands as the second leading cause of deaths worldwide due to single  infectious agent after Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The current challenges of drug ...

    Authors: Md. Sajid Hussain, Atul Vashist, Mahadevan Kumar, Neetu Kumra Taneja, Uma Shankar Gautam, Seema Dwivedi, Jaya Sivaswami Tyagi and Rajesh Kumar Gupta
    Citation: Microbial Cell Factories 2022 21:15
    Content type: Research Published on:

  8. The bacteriocin nisin is naturally produced by Lactococcus lactis as an inactive prepeptide that is modified posttranslationally resulting in five (methyl-)lanthionine rings characteristic for class Ia bacterioci...

    Authors: Dominik Weixler, Max Berghoff, Kirill V. Ovchinnikov, Sebastian Reich, Oliver Goldbeck, Gerd M. Seibold, Christoph Wittmann, Nadav S. Bar, Bernhard J. Eikmanns, Dzung B. Diep and Christian U. Riedel
    Citation: Microbial Cell Factories 2022 21:11
    Content type: Research Published on:

    The Correction to this article has been published in Microbial Cell Factories 2022 21:24