In the last decades the incidence of antibiotic-resistant bacteria affecting both human and animal medicine has exponentially increased. To tackle the burden of antimicrobial resistances (AMRs) pathogens, it is necessary to develop new antimicrobial drugs with novel modes of action. In many cases, products with antimicrobial properties have been obtained by chemical synthesis but it is a costly process and has certain limitations. In this context, the recombinant production of antimicrobial molecules from different origin appears as an appealing strategy. Among recombinant production systems, microorganisms are widely used. However, frequently antimicrobial molecules are difficult to produce, being necessary to develop new strategies for their production.
Thus, in this collection of Microbial Cell Factories we cover research towards the production, purification and characterization of novel antimicrobial molecules as alternatives to antibiotics using microbial cell factories as expression systems.
Editors: Drs Elena Garcia and Anna Aris, Institute for Food and Agricultural Research and Technology, Spain
The future of recombinant host defense peptides
The antimicrobial resistance crisis calls for the discovery and production of new antimicrobials. Host defense peptides (HDPs) are small proteins with potent antibacterial and immunomodulatory activities that ...