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Antibiotic resistance in the ICU

Edited by: Professor Steven Opal

The progressive loss of antibiotic activity as a result of dissemination of antibacterial resistance genes is increasingly recognized as global threat to humankind. Critical Care is therefore introducing a series of papers that examine the problem of progressive antibiotic resistance in the ICU. These articles will focus on the mechanisms of resistance, spread of antibiotic resistance genes, efforts to limit the further spread of MDR pathogens, and novel current and future therapeutic approaches to respond to the challenge of antibiotic resistance. We hope that this thematic series will inform the clinician about steps that we can take to confront the threat of antibiotic resistance.

This series of articles has not been sponsored. All articles have undergone the journal’s standard peer review process overseen by the Series Editor, with final decisions made by the Editor in Chief. The Series Editor and Editor in Chief declare no competing interests.

  1. The emergence of multi-drug resistant (MDR) microbial pathogens threatens the very foundation upon which standard antibacterial chemotherapy is based. We must consider non-antibiotic solutions to manage invasi...

    Authors: Steven M. Opal

    Citation: Critical Care 2016 20:397

    Content type: Editorial

    Published on:

    The Letter to this article has been published in Critical Care 2017 21:99

  2. Selective digestive decontamination (SDD) and selective oropharyngeal decontamination (SOD) have been associated with reduced mortality and lower ICU-acquired bacteremia and ventilator-associated pneumonia rat...

    Authors: Nienke L. Plantinga and Marc JM Bonten

    Citation: Critical Care 2015 19:259

    Content type: Review

    Published on:

  3. The rapid emergence and dissemination of antimicrobial-resistant microorganisms in ICUs worldwide constitute a problem of crisis dimensions. The root causes of this problem are multifactorial, but the core iss...

    Authors: Charles-Edouard Luyt, Nicolas Bréchot, Jean-Louis Trouillet and Jean Chastre

    Citation: Critical Care 2014 18:480

    Content type: Review

    Published on:

  4. Antibiotic resistance continues to spread even as society is experiencing a market failure of new antibiotic research and development (R&D). Scientific, economic, and regulatory barriers all contribute to the ...

    Authors: Brad Spellberg

    Citation: Critical Care 2014 18:228

    Content type: Review

    Published on: