BMC Infectious Diseases is calling for submissions to our Collection on Animal models in infectious diseases.
Understanding and treating infectious diseases hinges upon the crucial role of animal models, serving as instrumental tools in unraveling host-pathogen interactions, predicting human responses, and exploring therapeutic interventions. Animal models in infectious diseases serve as invaluable tools, allowing scientists to bridge the gap between the laboratory and the complex realities of human infections. These models, often rodents or non-human primates, play a crucial role in elucidating the mechanisms of pathogenesis, evaluating novel therapeutic strategies, and guiding public health interventions. However, the utility of animal models comes with inherent complexities and limitations. Genetic diversity, immunological variations, and ecological factors may influence the accuracy of these models to human conditions. Ongoing investigations explore techniques and advancements in tissue humanization, aiming to replicate human physiological conditions and further enhance the relevance of animal models in infectious diseases research.
This collection aims to spotlight the significance of animal models in infectious diseases research, providing a platform for comprehensive exploration across various disciplines. The primary focus is to explore various aspects of this theme such as the role of animal models in advancing our understanding of infectious diseases, insights into the dynamics of human-pathogen interactions, the susceptibility spectrums across different hosts, and innovative approaches to preclinical studies. Topics of interest include but are not limited to:
- Studies investigating the interaction between animal models and a diverse range of human pathogens, providing insights into pathogenesis
- Research on the varying degrees of susceptibility among different animal models to infectious agents, contributing to a nuanced understanding of host responses, exploration of different animal species as hosts to human pathogens and the implications for disease transmission
- Studies focusing on the humanization of viral receptors in animal models, enhancing the relevance of these models to human infections
- Investigations into the role of animal models in understanding and combating newly emerging pathogens
- Contributions discussing the methodologies and challenges involved in developing and refining animal models for infectious diseases
- Investigations into techniques and advancements in tissue humanization within animal models, aiming to replicate human physiological conditions
- Research highlighting the outcomes and implications of preclinical studies using animal models with a focus on translation to human contexts
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