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Current concepts in Alzheimer's disease research: molecules, models and translational perspectives

Dr Bart Rutten, Prof Harry Steinbusch

  1. Review

    Epigenetic regulation of adult neural stem cells: implications for Alzheimer’s disease

    Experimental evidence has demonstrated that several aspects of adult neural stem cells (NSCs), including their quiescence, proliferation, fate specification and differentiation, are regulated by epigenetic mec...

    Carlos P Fitzsimons, Emma van Bodegraven, Marijn Schouten, Roy Lardenoije, Konstantinos Kompotis, Gunter Kenis, Mark van den Hurk, Marco P Boks, Caroline Biojone, Samia Joca, Harry WM Steinbusch, Katie Lunnon, Diego F Mastroeni, Jonathan Mill, Paul J Lucassen, Paul D Coleman…

    Molecular Neurodegeneration 2014 9:25

    Published on: 25 June 2014

  2. Review

    Drosophila melanogaster as a model organism for Alzheimer’s disease

    Drosophila melanogaster provides an important resource for in vivo modifier screens of neurodegenerative diseases. To study the underlying pathogenesis of Alzheimer’s disease, fly models that address Tau or amylo...

    Katja Prüßing, Aaron Voigt and Jörg B Schulz

    Molecular Neurodegeneration 2013 8:35

    Published on: 22 November 2013

  3. Review

    Modeling Alzheimer’s disease in transgenic rats

    Alzheimer’s disease (AD) is the most common form of dementia. At the diagnostic stage, the AD brain is characterized by the accumulation of extracellular amyloid plaques, intracellular neurofibrillary tangles ...

    Sonia Do Carmo and A Claudio Cuello

    Molecular Neurodegeneration 2013 8:37

    Published on: 25 October 2013

  4. Review

    Blood–brain-barriers in aging and in Alzheimer’s disease

    The aging process correlates with a progressive failure in the normal cellular and organ functioning; these alterations are aggravated in Alzheimer’s disease (AD). In both aging and AD there is a general decre...

    Fernanda Marques, João Carlos Sousa, Nuno Sousa and Joana Almeida Palha

    Molecular Neurodegeneration 2013 8:38

    Published on: 22 October 2013

  5. Review

    Cross-talk of membrane lipids and Alzheimer-related proteins

    Alzheimer’s disease (AD) is neuropathologically characterized by the combined occurrence of extracellular β-amyloid plaques and intracellular neurofibrillary tangles in the brain. While plaques contain aggrega...

    Jochen Walter and Gerhild van Echten-Deckert

    Molecular Neurodegeneration 2013 8:34

    Published on: 22 October 2013

  6. Review

    Immunotherapy for Alzheimer’s disease: hoops and hurdles

    Alzheimer’s disease (AD) is the most common form of dementia, afflicting more than 30 million people worldwide. Currently, there is no cure or way to prevent this devastating disease. Extracellular plaques, co...

    Cynthia A Lemere

    Molecular Neurodegeneration 2013 8:36

    Published on: 22 October 2013