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Current concepts in Alzheimer's disease research: molecules, models and translational perspectives

Dr Bart Rutten, Prof Harry Steinbusch

  1. Content type: Review

    The amyloid cascade hypothesis has been the prevailing hypothesis in Alzheimer’s Disease research, although the final and most wanted proof i.e. fully successful anti-amyloid clinical trials in patients, is st...

    Authors: Ilie-Cosmin Stancu, Bruno Vasconcelos, Dick Terwel and Ilse Dewachter

    Citation: Molecular Neurodegeneration 2014 9:51

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  2. Content type: Review

    Experimental evidence has demonstrated that several aspects of adult neural stem cells (NSCs), including their quiescence, proliferation, fate specification and differentiation, are regulated by epigenetic mec...

    Authors: Carlos P Fitzsimons, Emma van Bodegraven, Marijn Schouten, Roy Lardenoije, Konstantinos Kompotis, Gunter Kenis, Mark van den Hurk, Marco P Boks, Caroline Biojone, Samia Joca, Harry WM Steinbusch, Katie Lunnon, Diego F Mastroeni, Jonathan Mill, Paul J Lucassen, Paul D Coleman…

    Citation: Molecular Neurodegeneration 2014 9:25

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  3. Content type: Review

    Alzheimer’s disease (AD) is the most common form of dementia. At the diagnostic stage, the AD brain is characterized by the accumulation of extracellular amyloid plaques, intracellular neurofibrillary tangles ...

    Authors: Sonia Do Carmo and A Claudio Cuello

    Citation: Molecular Neurodegeneration 2013 8:37

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  4. Content type: Review

    The aging process correlates with a progressive failure in the normal cellular and organ functioning; these alterations are aggravated in Alzheimer’s disease (AD). In both aging and AD there is a general decre...

    Authors: Fernanda Marques, João Carlos Sousa, Nuno Sousa and Joana Almeida Palha

    Citation: Molecular Neurodegeneration 2013 8:38

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  5. Content type: Review

    Alzheimer’s disease (AD) is neuropathologically characterized by the combined occurrence of extracellular β-amyloid plaques and intracellular neurofibrillary tangles in the brain. While plaques contain aggrega...

    Authors: Jochen Walter and Gerhild van Echten-Deckert

    Citation: Molecular Neurodegeneration 2013 8:34

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  6. Content type: Review

    Alzheimer’s disease (AD) is the most common form of dementia, afflicting more than 30 million people worldwide. Currently, there is no cure or way to prevent this devastating disease. Extracellular plaques, co...

    Authors: Cynthia A Lemere

    Citation: Molecular Neurodegeneration 2013 8:36

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