Edited by Prof Dr Uwe Wenzel and Dr Fabio Virgili
Genes and Nutrition is proud to present our newest thematic series, on alternative models in nutrigenomics. Animal models, and in particular rodent species, have been essential in medical research due to practical and ethical concerns associated with human experimentation. Results from animal studies guide translation of in vitro results to in vivo conditions and eventually to humans.
Millions of animals are used every year worldwide to foster basic research. In spite of well-defined protocols aiming to minimize pain, distress, and death by the animals, animal research nevertheless raises ethical concerns. Additional concerns are the requirement for trained and skilled personnel, time consuming protocols, and high costs. These practical issues increases the obvious uncertainties of translating animal data and results to humans.
The foundation of much nutritional sciences was obtained from rats, mice, and rabbits as experimental models, while the utilization of different species such as cats, dogs, pigs and primates, is relatively limited to specific fields of research.
This collection of articles, authored by researchers having a strong, long term experience on the matter, is dedicated to alternative experimental models that may eventually contribute to solving, at least in part, these critical issues. In particular, C. elegans, D. melanogaster, and the “zebra fish” (the cyprinide Danio rerio) are discussed as suitable expedient models in nutrigenomic research.
We hope that this collection of articles can provide some “food for thought” to our readers, to provide a critical overview on studies based on non-rodent models, and stimulate their “intent” to relieve, when possible, the use of rodent in research studies.
This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editors declare no competing interests.
View all collections published in Genes and Nutrition.
Micronutrients cannot be synthesized by humans and are obtained from three different sources: diet, gut microbiota, and oral supplements. The microbiota generates significant quantities of micronutrients, but ...
Citation: Genes & Nutrition 2020 15:4