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Alternative interventions to facilitate malaria elimination

It is now well-established that well-coordinated interventions are essential for malaria elimination, including integrated vector control management (with insecticide-treated bed nets and indoor residual spraying), reliable detection of cases, effective drugs for prevention and treatment, together with community involvement and enthusiasm to adhere to the interventions. After initial success, most programmes have reached stagnation, with progressive loss of earlier gains. The pressure needs to be kept full on, not only on policy-makers and sponsors to maintain and amplify the global effort in the long term, but also on the research community to continue developing new tools. Obviously, an effective vaccine (or vaccines) would be a powerful addition to the arsenal, and this is much needed, but vaccines have proven to be a difficult target to achieve. While waiting for the elusive vaccine, many have been looking for feasible alternatives and inventive new approaches adapted to specific situations or capable of solving specific problems. Such alternatives, big and small, have incremental value and in terms of elimination, every little helps. 

This Thematic series will collect published papers on innovative approaches and invite new contributions to stimulate further research.

  1. Malaria control in Tanzania currently relies primarily on long-lasting insecticidal nets and indoor residual spraying, alongside effective case management and behaviour change communication. This study explore...

    Authors: Marceline F. Finda, Nicola Christofides, Javier Lezaun, Brian Tarimo, Prosper Chaki, Ann H. Kelly, Ntuli Kapologwe, Paul Kazyoba, Basiliana Emidi and Fredros O. Okumu

    Citation: Malaria Journal 2020 19:164

    Content type: Research

    Published on:

  2. Cambodia targets malaria elimination by 2025. Rapid elimination will depend on successfully identifying and clearing malaria foci linked to forests. Expanding and maintaining universal access to early diagnosi...

    Authors: Dysoley Lek, James J. Callery, Chea Nguon, Mark Debackere, Siv Sovannaroth, Rupam Tripura, Marius Wojnarski, Patrice Piola, Soy Ty Khean, Kylie Manion, Sokomar Nguon, Amber Kunkel, Lieven Vernaeve, Thomas J. Peto, Emily Dantzer, Chan Davoeung…

    Citation: Malaria Journal 2020 19:151

    Content type: Meeting report

    Published on:

  3. Outdoor and early evening mosquito biting needs to be addressed if malaria elimination is to be achieved. While indoor-targeted interventions, such as insecticide-treated nets and indoor residual spraying, rem...

    Authors: Onyango P. Sangoro, Tegemeo Gavana, Marceline Finda, Winfrida Mponzi, Emmanuel Hape, Alex Limwagu, Nicodem J. Govella, Prosper Chaki and Fredros O. Okumu

    Citation: Malaria Journal 2020 19:148

    Content type: Research

    Published on:

  4. Despite huge investments and implementation of effective interventions for malaria, progress has stalled, with transmission being increasingly localized among difficult-to-reach populations and outdoor-biting ...

    Authors: Roly Gosling, John Chimumbwa, Petrina Uusiku, Sara Rossi, Henry Ntuku, Kelly Harvard, Chris White, Allison Tatarsky, Daniel Chandramohan and Ingrid Chen

    Citation: Malaria Journal 2020 19:125

    Content type: Opinion

    Published on:

  5. Residents of malaria-endemic communities spend several hours outdoors performing different activities, e.g. cooking, story-telling or eating, thereby exposing themselves to potentially-infectious mosquitoes. T...

    Authors: John P. Masalu, Marceline Finda, Gerry F. Killeen, Halfan S. Ngowo, Polius G. Pinda and Fredros O. Okumu

    Citation: Malaria Journal 2020 19:109

    Content type: Research

    Published on:

  6. Long-lasting insecticidal nets, or LLINs, have significantly reduced malaria morbidity and mortality over the past two decades. The net provides a physical barrier that decreases human-mosquito contact and the...

    Authors: Krijn P. Paaijmans and Silvie Huijben

    Citation: Malaria Journal 2020 19:73

    Content type: Opinion

    Published on:

  7. Molecular detection of low-density Plasmodium falciparum infections is essential for surveillance studies conducted to inform malaria control strategies in close-to-elimination settings. Molecular monitoring of r...

    Authors: Benjamin Grossenbacher, Aurel Holzschuh, Natalie E. Hofmann, Kali Abdullah Omar, Logan Stuck, Bakar Shariff Fakih, Abdullah Ali, Joshua Yukich, Manuel W. Hetzel and Ingrid Felger

    Citation: Malaria Journal 2020 19:50

    Content type: Research

    Published on: