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Aetiology of idiopathic scoliosis

This series on the Aetiology of idiopathic scoliosis aims to publish research, reviews, and opinion articles on the aetiology, pathogenesis and pathomechanisms (scoliogeny) of adolescent idiopathic scoliosis (AIS). While advances in biological knowledge have enabled significant research into understanding scoliogenic pathways, much is still unknown in relation to the biochemistry and endocrinology of AIS. In the first articles launched, the Series Editors, Professor R Geoffrey Burwell, Professor Peter Dangerfield and co-Editor-in-Chief, Dr Theodoros Grivas introduce the series with their Editorial that integrates the current understanding of AIS causation and etiopathogenetic information.

The Series Editors declare that they have no competing interests. This series has not been sponsored.

Edited by: Prof Richard Burwell, Prof Peter Dangerfield, Dr Theodoros B. Grivas

Published in Scoliosis and Spinal Disorders


  1. Idiopathic scoliosis (IS), the most common spinal deformity, affects otherwise healthy children and adolescents during growth. The aetiology is still unknown, although genetic factors are believed to be import...

    Authors: A. Grauers, E. Einarsdottir and P. Gerdhem
    Citation: Scoliosis and Spinal Disorders 2016 11:45
  2. This paper formulates a novel multifactorial Cascade Concept for the pathogenesis of adolescent idiopathic scoliosis (AIS). This Concept stems from the longitudinal findings of Clark et al. (J Bone Miner Res 2...

    Authors: R. Geoffrey Burwell, Emma M. Clark, Peter H. Dangerfield and Alan Moulton
    Citation: Scoliosis and Spinal Disorders 2016 11:8
  3. Right thoracic curvature, rib cage deformities and aortic left shift are features of adolescent idiopathic scoliosis that are correlated with each other. We recently reported that disturbance of ribcage develo...

    Authors: Toshio Doi, Yoshihiro Matsumoto, Osamu Tono, Kiyoshi Tarukado, Katsumi Harimaya, Seiji Okada, Kensuke Kubota, Mitsumasa Hayashida and Yukihide Iwamoto
    Citation: Scoliosis 2014 9:14
  4. There is no generally accepted scientific theory for the cause of adolescent idiopathic scoliosis (AIS). As part of its mission to widen understanding of scoliosis etiology, the International Federated Body on...

    Authors: Theodoros B Grivas, R Geoffrey Burwell and Peter H Dangerfield
    Citation: Scoliosis 2013 8:10
  5. This paper aims to integrate into current understanding of AIS causation, etiopathogenetic information presented at two Meetings during 2012 namely, the International Research Society of Spinal Deformities (IR...

    Authors: R Geoffrey Burwell, Peter H Dangerfield, Alan Moulton, Theodoros B Grivas and Jack CY Cheng
    Citation: Scoliosis 2013 8:4