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Advancing Nanomedicine Towards Clinical Translation

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Guest Editors: Jonathan F Lovell (University at Buffalo, NY, USA), Honglin Jin (Huazhong Agricultural University, China), Wei Chen and Jun Dai (Tongji Medical College of Huazhong University of Science and Technology, China).

Journal of Nanobiotechnology invites submissions to a collection on Advancing nanomedicine towards clinical translation.

Nanomedicine, the application of nanotechnology to health and medicine, emerged in research publications since the late 1990s, which has already exhibited promising potential in the development of various products including therapeutics, diagnostic imaging agents, in vitro diagnostics, and medical devices.

Along with the recent progress, efforts have been devoted to developing nanobiotechnology for next-generation cancer theranostics, vaccines, and drug/gene delivery systems. More specifically, nanomedicine in the forms of imaging probes, theranostic drugs, cancer vaccines, and smart devices, are developed for target-specific and bioresponsive diagnosis and treatment of life-threatening diseases, especially cancer, diabetes, and brain dysfunction and so on. 

This special issue aims at better understanding the role and application of nanotechnology-based formulations and smart drug delivery devices for clinical translation, and will comprise a selection of original research papers and reviews focusing on advancing nanomedicine with highly clinical potentials.

The potential subjects include, but are not limited to:
1)    Imaging probes in preclinical/clinical nanomedicine 
2)    Theranostic drugs in preclinical/clinical nanomedicine 
3)    Diagnostic devices in preclinical/clinical nanomedicine 
4)    Advanced drug formulation in preclinical/clinical nanomedicine
5)    Vaccine technology in preclinical/clinical nanomedicine

Further information about the journal, including details of the aims and scope, can be found here.

Submissions of original Research, Methodology and Review papers are invited. Deadline: 31st May 2022. Please submit via journal online submission system and indicate during submission that you are submitting to the Advancing nanomedicine towards clinical translation collection. All manuscripts received will be subject to editorial triage and peer review as is standard for the journal.

Articles will be published continuously in the main journal and highlighted on the collection homepage as soon as they are ready.

  1. No commercial vaccines are available against drug-resistant Shigella due to serotype-specific/narrow-range of protection. Nanoparticle-based biomimetic vaccines involving stable, conserved, immunogenic proteins f...

    Authors: Namrata Baruah, Nadim Ahamad, Prolay Halder, Hemanta Koley and Dhirendra S. Katti
    Citation: Journal of Nanobiotechnology 2023 21:34
  2. Despite significant progress in synthetic polymer chemistry and in control over tuning the structures and morphologies of nanoparticles, studies on morphologic design of nanomaterials for the purpose of optimi...

    Authors: Fatma Al-Zahraa Sayed, Noura G. Eissa, Yidan Shen, David A. Hunstad, Karen L. Wooley and Mahmoud Elsabahy
    Citation: Journal of Nanobiotechnology 2022 20:536
  3. Currently available anti-leukemia drugs have shown limited success in the treatment of acute myeloid leukemia (AML) due to their poor access to bone marrow niche supporting leukemic cell proliferation.

    Authors: Ki Hyun Bae, Fritz Lai, Jamie Mong, Akiko Niibori-Nambu, Kiat Hwa Chan, Zhisheng Her, Motomi Osato, Min-Han Tan, Qingfeng Chen and Motoichi Kurisawa
    Citation: Journal of Nanobiotechnology 2022 20:481
  4. Osteoporosis (OP) is characterized by a loss in bone mass and mineral density. The stimulation of the canonical Wnt/β-catenin pathway has been reported to promote bone formation, this pathway is controlled by ...

    Authors: Patricia García-García, Ricardo Reyes, Daniel García-Sánchez, Flor María Pérez-Campo, José Carlos Rodríguez-Rey, Carmen Évora, Patricia Díaz-Rodríguez and Araceli Delgado
    Citation: Journal of Nanobiotechnology 2022 20:462
  5. Photodynamic therapy (PDT), and sonodynamic therapy (SDT) that developed from PDT, have been studied for decades to treat solid tumors. Compared with other deep tumors, the accessibility of urological tumors (...

    Authors: Xiao Hu, Yu-Sen Zhang, Yi-Chao Liu, Na Wang, Xian-Tao Zeng and Ling-Ling Zhang
    Citation: Journal of Nanobiotechnology 2022 20:437
  6. Light-mediated nanotherapeutics have recently emerged as promising strategies to precisely control the activation of therapeutic reagents and imaging probe both in vitro and in vivo, largely ascribed to their ...

    Authors: Dan Zhao, Wang Zhang, Shuang Yu, Si-Lei Xia, Ya-Nan Liu and Guan-Jun Yang
    Citation: Journal of Nanobiotechnology 2022 20:421
  7. The rapid advancement of nanomedicine and nanoparticle (NP) materials presents novel solutions potentially capable of revolutionizing health care by improving efficacy, bioavailability, drug targeting, and saf...

    Authors: Saquib Waheed, Zhibin Li, Fangyingnan Zhang, Anna Chiarini, Ubaldo Armato and Jun Wu
    Citation: Journal of Nanobiotechnology 2022 20:395
  8. Injuries to the urethra can be caused by malformations, trauma, inflammation, or carcinoma, and reconstruction of the injured urethra is still a significant challenge in clinical urology. Implanting grafts for...

    Authors: Qinyuan Tan, Hanxiang Le, Chao Tang, Ming Zhang, Weijie Yang, Yazhao Hong and Xiaoqing Wang
    Citation: Journal of Nanobiotechnology 2022 20:392
  9. Colorectal cancer is considered one of the major malignancies that threaten the lives and health of people around the world. Patients with CRC are prone to post-operative local recurrence or metastasis, and so...

    Authors: Yu Guo, Min Wang, Yongbo Zou, Longhai Jin, Zeyun Zhao, Qi Liu, Shuang Wang and Jiannan Li
    Citation: Journal of Nanobiotechnology 2022 20:371
  10. Oral delivery of therapeutics is the preferred route of administration due to ease of administration which is associated with greater patient medication adherence. One major barrier to oral delivery and intest...

    Authors: Deepak A. Subramanian, Robert Langer and Giovanni Traverso
    Citation: Journal of Nanobiotechnology 2022 20:362
  11. Non-alcoholic fatty liver disease (NAFLD) is a usual chronic liver disease and lacks non-invasive biomarkers for the clinical diagnosis and prognosis. Extracellular vesicles (EVs), a group of heterogeneous sma...

    Authors: Qingfu Zhu, Hengrui Li, Zheng Ao, Hao Xu, Jiaxin luo, Connor Kaurich, Rui Yang, Pei-Wu Zhu, Sui-Dan Chen, Xiao-Dong Wang, Liang-Jie Tang, Gang Li, Ou-Yang Huang, Ming-Hua Zheng, Hui-Ping Li and Fei Liu
    Citation: Journal of Nanobiotechnology 2022 20:349
  12. Cancer remains a serious threat to human health owing to the lack of effective treatments. Photodynamic therapy (PDT) has emerged as a promising non-invasive cancer treatment that consists of three main elemen...

    Authors: Zijuan Meng, Huiying Xue, Tingting Wang, Biao Chen, Xiyuan Dong, Lili Yang, Jun Dai, Xiaoding Lou and Fan Xia
    Citation: Journal of Nanobiotechnology 2022 20:344
  13. The prevalence of end-stage kidney disease (ESKD) is rapidly increasing with the need for regenerative therapies. Adult stem cell derived kidney tubuloids have the potential to functionally mimic the adult kid...

    Authors: Rafael Soares Lindoso, Fjodor A. Yousef Yengej, Franziska Voellmy, Maarten Altelaar, Estela Mancheño Juncosa, Theano Tsikari, Carola M. E. Ammerlaan, Bas W. M. Van Balkom, Maarten B. Rookmaaker, Marianne C. Verhaar and Rosalinde Masereeuw
    Citation: Journal of Nanobiotechnology 2022 20:326
  14. Chemoresistance is often a cause of the failure of chemotherapy in cancer treatment. Sorcin (SRI) is a soluble resistance-related calcium-binding protein involved in chemoresistant processes and is overexpress...

    Authors: Chenglong Wang, Xiaolin Xu, Peipei Zhang, Shuhan Xiong, Jia Yuan, Xuzhu Gao, Wencai Guan, Fanchen Wang, Xin Li, Hongjing Dou and Guoxiong Xu
    Citation: Journal of Nanobiotechnology 2022 20:319
  15. Muscle atrophy is a frequently observed complication, characterized by the loss of muscle mass and strength, which diminishes the quality of life and survival. No effective therapy except exercise is currently...

    Authors: Rui Chen, Weilin Yuan, Yongjun Zheng, Xiaolan Zhu, Bing Jin, Tingting Yang, Yuwei Yan, Wanru Xu, Hongjian Chen, Juan Gao, Guoping Li, Priyanka Gokulnath, Gururaja Vulugundam, Jin Li and Junjie Xiao
    Citation: Journal of Nanobiotechnology 2022 20:304
  16. Traumatic brain injury (TBI) is a cause of disability and death worldwide, but there are currently no specific treatments for this condition. Release of excess reactive oxygen species (ROS) in the injured brai...

    Authors: Shengyang Fu, Shu Zhao, Huili Chen, Weitao Yang, Xiaohuan Xia, Xiaonan Xu, Zhanping Liang, Xuanran Feng, Zhuo Wang, Pu Ai, Lu Ding, Qingyuan Cai, Yi Wang, Yanyan Zhang, Jie Zhu, Bingbo Zhang…
    Citation: Journal of Nanobiotechnology 2022 20:299
  17. Skin thickness is closely related to the appearance of human skin, such as sagging and wrinkling, which primarily depends on the level of collagen I synthesized by dermal fibroblasts (DFs). Small extracellular...

    Authors: Qin Zou, Mei Zhang, Rong Yuan, Yifei Wang, Zhengyin Gong, Rui Shi, Yujing Li, Kaixin Fei, Chenggang Luo, Ying Xiong, Ting Zheng, Li Zhu, Guoqing Tang, Mingzhou Li, Xuewei Li and Yanzhi Jiang
    Citation: Journal of Nanobiotechnology 2022 20:296
  18. With rich carboxyl groups in the side chain, biodegradable polymalic acid (PMLA) is an ideal delivery platform for multifunctional purposes, including imaging diagnosis and targeting therapy. This polymeric ma...

    Authors: Xing Huang, Liusheng Xu, Hui Qian, Xinghuan Wang and Zhimin Tao
    Citation: Journal of Nanobiotechnology 2022 20:295
  19. Radiation-induced skin injury (RISI) is a common complication of radiotherapy. Interferon-alpha inducible protein 6 (IFI6) significantly reduces the radiation sensitivity of HaCaT cells. Sodium alginate (SA) h...

    Authors: Jie Hao, Mengyi Sun, Dong Li, Tao Zhang, Jianjun Li and Daijun Zhou
    Citation: Journal of Nanobiotechnology 2022 20:288
  20. Nowadays, brain tumors are challenging problems, and the key of therapy is ensuring therapeutic drugs cross the blood–brain barrier (BBB) effectively. Although the efficiency of drug transport across the BBB c...

    Authors: Shuo Zhang, Shuai Zhang, Siyuan Luo, Peng Tang, Mingxi Wan, Daocheng Wu and Wei Gao
    Citation: Journal of Nanobiotechnology 2022 20:287
  21. Patients with diabetic foot ulcers usually suffer from inefficient epithelisation and angiogenesis accompanied by chronic wound healing. Diabetic foot ulcers remain a major challenge in clinical medicine; howe...

    Authors: Pei Wang, Yun Wang, Yang Yi, Yan Gong, Haoran Ji, Yuci Gan, Fei Xie, Jinchen Fan and Xiansong Wang
    Citation: Journal of Nanobiotechnology 2022 20:259
  22. Applying traditional fluorescence navigation technologies in hepatocellular carcinoma is severely restricted by high false-positive rates, variable tumor differentiation, and unstable fluorescence performance.

    Authors: Pan He, Yongfu Xiong, Jinfa Ye, Biaoqi Chen, Hongwei Cheng, Hao Liu, Yating Zheng, Chengchao Chu, Jingsong Mao, Aizheng Chen, Yang Zhang, Jingdong Li, Jie Tian and Gang Liu
    Citation: Journal of Nanobiotechnology 2022 20:250
  23. Immunotherapies have been gaining attention for the prevention of cancer recurrence and metastasis. Cancer immunotherapy can induce memory cells to target cancer-specific antigens and, thus, selectively kill c...

    Authors: Juyoung Hwang, Eun-Koung An, Wei Zhang, Hyo Jeong Kim, Youngho Eom and Jun-O. Jin
    Citation: Journal of Nanobiotechnology 2022 20:245
  24. Acute myocardial infarction (MI) induces a sterile inflammatory response that may result in poor cardiac remodeling and dysfunction. Despite the progress in anti-cytokine biologics, anti-inflammation therapy o...

    Authors: Jing Chen, Yanan Song, Qiaozi Wang, Qiyu Li, Haipeng Tan, Jinfeng Gao, Ning Zhang, Xueyi Weng, Dili Sun, Wusiman Yakufu, Zhengmin Wang, Juying Qian, Zhiqing Pang, Zheyong Huang and Junbo Ge
    Citation: Journal of Nanobiotechnology 2022 20:218
  25. Extracellular vesicles (EVs), spherical biological vesicles, mainly contain nucleic acids, proteins, lipids and metabolites for biological information transfer between cells. Microparticles (MPs), a subtype of...

    Authors: Yan Hu, Yajie Sun, Chao Wan, Xiaomeng Dai, Shuhui Wu, Pui-Chi Lo, Jing Huang, Jonathan F. Lovell, Honglin Jin and Kunyu Yang
    Citation: Journal of Nanobiotechnology 2022 20:189
  26. Calcium ions (Ca2+) participates in various intracellular signal cascades and especially plays a key role in pathways relevant to cancer cells. Mitochondrial metabolism stimulated by calcium overload can trigger ...

    Authors: Ying Zhou, Shisong Jing, Sainan Liu, Xizhong Shen, Lihan Cai, Changfeng Zhu, Yicheng Zhao and Maolin Pang
    Citation: Journal of Nanobiotechnology 2022 20:188
  27. Albumin-biomineralized copper sulfide nanoparticles (Cu2−xS NPs) have attracted much attention as an emerging phototheranostic agent due to their advantages of facile preparation method and high biocompatibility....

    Authors: Ya-Nan Xia, He Zu, Haoxiang Guo, Tianyan Jiang, Siqi Yang, Huan Yu, Shaodian Zhang, Heng Ding, Xiaoyu Li, Yangyun Wang, Yong Wang and Leshuai W. Zhang
    Citation: Journal of Nanobiotechnology 2022 20:185
  28. Stem cells from human exfoliated deciduous teeth (SHED) can be used as a potential clinical material. But the use of xenogeneic ingredients will increase the risk of zoonotic disease transmission. Human platel...

    Authors: Tong Lei, Yanyan Liu, Shiwen Deng, Zhuangzhuang Xiao, Yanjie Yang, Xiaoshuang Zhang, Wangyu Bi and Hongwu Du
    Citation: Journal of Nanobiotechnology 2022 20:176
  29. Ulcerative colitis (UC), a subtype of inflammatory bowel disease (IBD), has evolved into a global burden given its high incidence. There is a clinical need to create better diagnostic and therapeutic approache...

    Authors: Xiangji Yan, Chunhua Yang, Mei Yang, Yana Ma, Yuanyuan Zhang, Yujie Zhang, Cui Liu, Qiuran Xu, Kangsheng Tu and Mingzhen Zhang
    Citation: Journal of Nanobiotechnology 2022 20:99