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Added Value Chemicals and Biofuels

Edited by Prof Akihiko Kondo

To ensure a reliable future source of added value chemicals and energy, the utilization of sustainable biomass has considerable advantages over petroleum-based sources. Microbial Cell Factories presents this ongoing series to cover the development of microorganisms for the production of various added value chemicals and advanced biofuels from biomass. Potential topics include, but are not limited, to engineering microbial strains with high biomass hydrolysis activity, high product yield, productivities and titers, ability to use many carbon sources, and resistance to toxic compounds released during the pretreatment of biomass.

Please see here for further details, including how to submit your new work to the series.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editors declare no competing interests.

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  1. Content type: RESEARCH

    3-Ketosteroid-Δ1-dehydrogenase (KstD) is a key enzyme in the metabolic pathway for chemical modifications of steroid hormones. Only a few KstDs have thus far been characterized biochemically and applied for th...

    Authors: Ruijie Zhang, Xiangcen Liu, Yushi Wang, Yuchang Han, Junsong Sun, Jiping Shi and Baoguo Zhang

    Citation: Microbial Cell Factories 2018 17:77

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  2. Content type: Review

    Plant natural products (PNPs) are widely used as pharmaceuticals, nutraceuticals, seasonings, pigments, etc., with a huge commercial value on the global market. However, most of these PNPs are still being extr...

    Authors: Xiaonan Liu, Wentao Ding and Huifeng Jiang

    Citation: Microbial Cell Factories 2017 16:125

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  3. Content type: Research

    Low catalytic activities of pathway enzymes are often a limitation when using microbial based chemical production. Recent studies indicated that the enzyme activity of aldehyde decarbonylase (AD) is a critical...

    Authors: Min-Kyoung Kang, Yongjin J. Zhou, Nicolaas A. Buijs and Jens Nielsen

    Citation: Microbial Cell Factories 2017 16:74

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  4. Content type: Research

    Pterostilbene, a structural analog of resveratrol, has higher oral bioavailability and bioactivity than that of the parent compound; but is far less abundant in natural sources. Thus, to efficiently obtain thi...

    Authors: Kyung Taek Heo, Sun-Young Kang and Young-Soo Hong

    Citation: Microbial Cell Factories 2017 16:30

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  5. Content type: Research

    Microbial production of monoterpenes provides a promising substitute for traditional chemical-based methods, but their production is lagging compared with sesquiterpenes. Geraniol, a valuable monoterpene alcoh...

    Authors: Jianzhi Zhao, Chen Li, Yan Zhang, Yu Shen, Jin Hou and Xiaoming Bao

    Citation: Microbial Cell Factories 2017 16:17

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  6. Content type: Research

    The yeast amino acid catabolism plays an important role in flavour generation since higher alcohols and acetate esters, amino acid catabolism end products, are key components of overall flavour and aroma in fe...

    Authors: Jiri Stribny, Gabriele Romagnoli, Roberto Pérez-Torrado, Jean-Marc Daran and Amparo Querol

    Citation: Microbial Cell Factories 2016 15:51

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  7. Content type: Research

    With increasing concern about the environmental impact of a petroleum based economy, focus has shifted towards greener production strategies including metabolic engineering of microbes for the conversion of pl...

    Authors: Sarah Rodriguez, Charles M. Denby, T. Van Vu, Edward E. K. Baidoo, George Wang and Jay D. Keasling

    Citation: Microbial Cell Factories 2016 15:48

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  8. Content type: Research

    Several plant diterpenes have important biological properties. Among them, forskolin is a complex labdane-type diterpene whose biological activity stems from its ability to activate adenylyl cyclase and to ele...

    Authors: Codruta Ignea, Efstathia Ioannou, Panagiota Georgantea, Fotini A. Trikka, Anastasia Athanasakoglou, Sofia Loupassaki, Vassilios Roussis, Antonios M. Makris and Sotirios C. Kampranis

    Citation: Microbial Cell Factories 2016 15:46

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  9. Content type: Research

    PM100117 and PM100118 are glycosylated polyketides with remarkable antitumor activity, which derive from the marine symbiotic actinobacteria Streptomyces caniferus GUA-...

    Authors: Raúl García Salcedo, Carlos Olano, Cristina Gómez, Rogelio Fernández, Alfredo F. Braña, Carmen Méndez, Fernando de la Calle and José A. Salas

    Citation: Microbial Cell Factories 2016 15:44

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  10. Content type: Research

    Fermentative aromas play a key role in the organoleptic profile of young wines. Their production depends both on yeast strain and fermentation conditions. A present-day trend in the wine industry consists in d...

    Authors: Stéphanie Rollero, Jean-Roch Mouret, Isabelle Sanchez, Carole Camarasa, Anne Ortiz-Julien, Jean-Marie Sablayrolles and Sylvie Dequin

    Citation: Microbial Cell Factories 2016 15:32

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  11. Content type: Research

    Imbalance in cofactors causing the accumulation of intermediates in biosynthesis pathways is a frequently occurring problem in metabolic engineering when optimizing a production pathway in a microorganism. In ...

    Authors: Veerle E. T. Maervoet, Sofie L. De Maeseneire, Fatma G. Avci, Joeri Beauprez, Wim K. Soetaert and Marjan De Mey

    Citation: Microbial Cell Factories 2016 15:23

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  12. Content type: Research

    Plant parasitic nematodes are harmful to agricultural crops and plants, and may cause severe yield losses. Cinnamaldehyde, a volatile, yellow liquid commonly used as a flavoring or food additive, is increasing...

    Authors: Hyun Bae Bang, Yoon Hyeok Lee, Sun Chang Kim, Chang Keun Sung and Ki Jun Jeong

    Citation: Microbial Cell Factories 2016 15:16

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  13. Content type: Research

    Protoilludene is a valuable sesquiterpene and serves as a precursor for several medicinal compounds and antimicrobial chemicals. It can be synthesized by heterologous expression of protoilludene synthase in Esche...

    Authors: Liyang Yang, Chonglong Wang, Jia Zhou and Seon-Won Kim

    Citation: Microbial Cell Factories 2016 15:14

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  14. Content type: Research

    Sustainable alternatives for the production of fuels and chemicals are needed to reduce our dependency on fossil resources and to avoid the negative impact of their excessive use on the global climate. Lignoce...

    Authors: Stefan Marcus Gaida, Andrea Liedtke, Andreas Heinz Wilhelm Jentges, Benedikt Engels and Stefan Jennewein

    Citation: Microbial Cell Factories 2016 15:6

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  15. Content type: Research

    Enantiopure (S)-1-(4-methoxyphenyl) ethanol {(S)-MOPE} can be employed as an important synthon for the synthesis of cycloalkyl [b] indoles with the treatment function for g...

    Authors: Ping Wei, Jing Liang, Jing Cheng, Min-Hua Zong and Wen-Yong Lou

    Citation: Microbial Cell Factories 2016 15:5

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  16. Content type: Research

    Polylactic acid (PLA) is one important chemical building block that is well known as a biodegradable and a biocompatible plastic. The traditional lactate fermentation pr...

    Authors: Nilnate Assavasirijinda, Deyong Ge, Bo Yu, Yanfen Xue and Yanhe Ma

    Citation: Microbial Cell Factories 2016 15:3

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  17. Content type: Research

    Isepamicin is a weakly toxic but highly active aminoglycoside antibiotic derivative of gentamicin B. Gentamicin B is a naturally occurring minor component isolated from Micromonospora echinospora. 2ʹ-NH2-containi...

    Authors: Xianpu Ni, Zhenpeng Sun, Yawen Gu, Hao Cui and Huanzhang Xia

    Citation: Microbial Cell Factories 2016 15:1

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  18. Content type: Research

    Tannase is an enzyme that catalyses the breakdown of ester bonds in gallotannins such as tannic acid. In recent years, the interest on bacterial tannases has increased b...

    Authors: Pedro Aguilar-Zárate, Mario A. Cruz, Julio Montañez, Raúl Rodríguez-Herrera, Jorge E. Wong-Paz, Ruth E. Belmares and Cristóbal N. Aguilar

    Citation: Microbial Cell Factories 2015 14:209

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  19. Content type: Research

    Although some microorganisms can convert glycerol into valuable products such as polyunsaturated fatty acids, the yields are relative low due primarily to an inefficient assimilation of glycerol. Mortierella alpi...

    Authors: Guangfei Hao, Haiqin Chen, Zhennan Gu, Hao Zhang, Wei Chen and Yong Q. Chen

    Citation: Microbial Cell Factories 2015 14:205

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  20. Content type: Research

    Methylxanthines are natural and synthetic compounds found in many foods, drinks, pharmaceuticals, and cosmetics. Aside from caffeine, production of many methylxanthines is currently performed by chemical synth...

    Authors: Khalid H. R. Algharrawi, Ryan M. Summers, Sridhar Gopishetty and Mani Subramanian

    Citation: Microbial Cell Factories 2015 14:203

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  21. Content type: Review

    Adenosine-5′-triphosphate (ATP) is consumed as a biological energy source by many intracellular reactions. Thus, the intracellular ATP supply is required to maintain cellular ho...

    Authors: Kiyotaka Y. Hara and Akihiko Kondo

    Citation: Microbial Cell Factories 2015 14:198

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  22. Content type: Research

    As a metabolic engineering tool, an adaptive laboratory evolution (ALE) experiment was performed to increase the specific growth rate (µ) in an Escherichia coli strain lacking PTS, originally engineered to increa...

    Authors: César Aguilar, Noemí Flores, Fernando Riveros-McKay, Diana Sahonero-Canavesi, Susy Beatriz Carmona, Otto Geiger, Adelfo Escalante and Francisco Bolívar

    Citation: Microbial Cell Factories 2015 14:194

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  23. Content type: Research

    Quorum sensing (QS) networks are more commonly known as acyl homoserine lactone (HSL) networks. Recently, p-coumaroyl-HSL has been found in a photosynthetic bacterium. p-coumaroyl-HSL is derived from a lignin mon...

    Authors: Sun-Young Kang, Jae Kyoung Lee, Jae-Hyuk Jang, Bang Yeon Hwang and Young-Soo Hong

    Citation: Microbial Cell Factories 2015 14:191

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  24. Content type: Research

    Poly(3-hydroxybutyrate) (PHB), have been considered to be good candidates for completely biodegradable polymers due to their similar mechanical properties to petroleum-d...

    Authors: Zhenquan Lin, Yan Zhang, Qianqian Yuan, Qiaojie Liu, Yifan Li, Zhiwen Wang, Hongwu Ma, Tao Chen and Xueming Zhao

    Citation: Microbial Cell Factories 2015 14:185

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  25. Content type: Research

    Some types of flavonoid intermediates seemed to be restricted to plants. Naringenin is a typical plant metabolite, that has never been reported to be produced in prokari...

    Authors: Rubén Álvarez-Álvarez, Alma Botas, Silvia M. Albillos, Angel Rumbero, Juan F. Martín and Paloma Liras

    Citation: Microbial Cell Factories 2015 14:178

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  26. Content type: Research

    2,3-Butanediol is an important bulk chemical with a wide range of applications. In bacteria, this metabolite is synthesised from pyruvate via a three-step pathway involving α-acetolactate synthase, α-acetolact...

    Authors: Dušica Radoš, Ana Lúcia Carvalho, Stefan Wieschalka, Ana Rute Neves, Bastian Blombach, Bernhard J. Eikmanns and Helena Santos

    Citation: Microbial Cell Factories 2015 14:171

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  27. Content type: Research

    There is a strong interest in using photosynthetic cyanobacteria as production hosts for biofuels and chemicals. Recent work has shown the benefit of pathway engineering, enzyme tolerance, and co-factor usage ...

    Authors: Josefine Anfelt, Danuta Kaczmarzyk, Kiyan Shabestary, Björn Renberg, Johan Rockberg, Jens Nielsen, Mathias Uhlén and Elton P. Hudson

    Citation: Microbial Cell Factories 2015 14:167

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  28. Content type: Research

    The industrial production of riboflavin mostly relies on the microbial fermentation of flavinogenic microorganisms and Ashbya gossypii is the main industrial producer of the vitamin. Accordingly, bioengineering s...

    Authors: Rodrigo Ledesma-Amaro, Cristina Serrano-Amatriain, Alberto Jiménez and José Luis Revuelta

    Citation: Microbial Cell Factories 2015 14:163

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  29. Content type: Research

    Glutathione (GSH), a pivotal non-protein thiol, can be biosynthesized through three pathways in different organisms: (1) two consecutive enzymatic reactions catalyzed by γ-glutamylcysteine synthetase (Gsh1 or ...

    Authors: Liang Tang, Weiwei Wang, Wenlong Zhou, Kai Cheng, Yan Yang, Minzhi Liu, Kedi Cheng and Wei Wang

    Citation: Microbial Cell Factories 2015 14:139

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  30. Content type: Research

    Flavonoids are bio-active specialized plant metabolites which mainly occur as different glycosides. Due to the increasing market demand, various biotechnological approaches have been developed which use Escherich...

    Authors: Frederik De Bruyn, Maarten Van Brempt, Jo Maertens, Wouter Van Bellegem, Dries Duchi and Marjan De Mey

    Citation: Microbial Cell Factories 2015 14:138

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  31. Content type: Research

    Monoterpenes are important contributors to grape and wine aroma. Moreover, certain monoterpenes have been shown to display health benefits with antimicrobial, anti-inflammatory, anticancer or hypotensive prope...

    Authors: Ester Pardo, Juan Rico, José Vicente Gil and Margarita Orejas

    Citation: Microbial Cell Factories 2015 14:136

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  32. Content type: Research

    Synthetic glucocorticoids like methylprednisolone (medrol) are of high pharmaceutical interest and represent powerful drugs due to their anti-inflammatory and immunosupp...

    Authors: Simone Brixius-Anderko, Lina Schiffer, Frank Hannemann, Bernd Janocha and Rita Bernhardt

    Citation: Microbial Cell Factories 2015 14:135

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  33. Content type: Research

    Ethylene glycol (EG) is a bulk chemical that is mainly used as an anti-freezing agent and a raw material in the synthesis of plastics. Production of commercial EG currently exclusively relies on chemical synth...

    Authors: Ceren Alkim, Yvan Cam, Debora Trichez, Clément Auriol, Lucie Spina, Amélie Vax, François Bartolo, Philippe Besse, Jean Marie François and Thomas Walther

    Citation: Microbial Cell Factories 2015 14:127

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  34. Content type: Research

    Bacillus amyloliquefaciens B10-127 exhibited an excellent ability for industrial-scale microbial fermentation of 2,3-butanediol (2,3-BD) from biodiesel-derived glycerol. However, the a...

    Authors: Taowei Yang, Zhiming Rao, Xian Zhang, Meijuan Xu, Zhenghong Xu and Shang-Tian Yang

    Citation: Microbial Cell Factories 2015 14:122

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  35. Content type: Research

    l-Threonine is an important amino acid for animal feed. Though the industrial fermentation technology of threonine achieved a very high level, t...

    Authors: Ya’nan Liu, Qinggang Li, Ping Zheng, Zhidan Zhang, Yongfei Liu, Cunmin Sun, Guoqiang Cao, Wenjuan Zhou, Xiaowei Wang, Dawei Zhang, Tongcun Zhang, Jibin Sun and Yanhe Ma

    Citation: Microbial Cell Factories 2015 14:121

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  36. Content type: Research

    Sugar alcohols have been widely applied in the fields of food and medicine owing to their unique properties. Compared to chemical production, microbial production of sugar alcohols has become attractive becaus...

    Authors: Guoqiang Zhang, Yuping Lin, Xianni Qi, Lixian Wang, Peng He, Qinhong Wang and Yanhe Ma

    Citation: Microbial Cell Factories 2015 14:112

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