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Article Collection of Papers Related to Oxidatively Damaged Bases Dedicated to Susumu Nishimura

Edited by Dr. Hiroyuki Kamiya

susumuGenes and Environment has collected reviews and research articles for a special issue commemorating the memory of late Dr. Susumu Nishimura (1931-2022).

Dr. Nishimura was a great biochemist and molecular biologist, and his achievements on 8-hydorxyguanine/8-oxoguanine were outstanding in the area related to this journal. The issue includes 1. formation of DNA adducts, 2. mutagenicity, carcinogenicity, and repair of oxidized guanine bases, and 3. oxidized guanine as a biomarker.

  1. The DNA-damaging compounds in heated cooking oil were identified as guanosine adducts. Heated vegetable oil was subjected to deep-frying conditions at 170 °C for 45 min, reacted with isopropylidene guanosine (...

    Authors: Hiroshi Kasai and Kazuaki Kawai
    Citation: Genes and Environment 2023 45:27
  2. A comprehensive understanding of DNA adducts, one of the most plausible origins of cancer mutations, is still elusive, especially in human tissues in clinical settings. Recent technological developments have f...

    Authors: Ippei Ohnishi, Yuji Iwashita, Yuto Matsushita, Shunsuke Ohtsuka, Takashi Yamashita, Keisuke Inaba, Atsuko Fukazawa, Hideto Ochiai, Keigo Matsumoto, Nobuhito Kurono, Yoshitaka Matsushima, Hiroki Mori, Shioto Suzuki, Shohachi Suzuki, Fumihiko Tanioka and Haruhiko Sugimura
    Citation: Genes and Environment 2021 43:12
  3. Oxidative stress leads to many kinds of diseases. Currently, urinary 8-hydroxydeoxyguanosine (8-OHdG) is widely measured as an oxidative stress biomarker. There is a specific advantage if saliva can be used as...

    Authors: Kazuaki Kawai, Hiroshi Kasai, Yun-Shan Li, Yuya Kawasaki, Shintaro Watanabe, Masanori Ohta, Toru Honda and Hiroshi Yamato
    Citation: Genes and Environment 2018 40:5
  4. Guanine is the most readily oxidized of the four DNA bases, and guanine oxidation products cause G:C-T:A and G:C-C:G transversions through DNA replication. 8-Oxo-7,8-dihydroguanine (8-oxoG) causes G:C-T:A tran...

    Authors: Katsuhito Kino, Masayo Hirao-Suzuki, Masayuki Morikawa, Akane Sakaga and Hiroshi Miyazawa
    Citation: Genes and Environment 2017 39:21
  5. Guanine oxidation occurs in both DNA and the cellular nucleotide pool, and one of the major products is 8-hydroxyguanine (8-oxo-7,8-dihydroguanine). The mutagenic potentials of this oxidized base have been exa...

    Authors: Tetsuya Suzuki and Hiroyuki Kamiya
    Citation: Genes and Environment 2016 39:2

    The Erratum to this article has been published in Genes and Environment 2017 39:20

  6. We investigated the enhancing effect of metal ions on several mutagens and examined their mechanism of action. We performed the Ames tests on six mutagens, i.e., 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide, 4-ni...

    Authors: Nobuyoshi Fujii, Shigemitsu Yano and Kenji Takeshita
    Citation: Genes and Environment 2016 38:21
  7. In DNA, 8-oxo-7,8-dihydroguanine (GO, 8-hydroxyguanine) is one of the most pivotal oxidatively damaged bases and induces G:C → T:A transversion mutations. DNA polymerase λ preferentially inserts dCTP opposite GO ...

    Authors: Hiroyuki Kamiya, Masahiro Kurokawa, Tetsuaki Makino, Miwako Kobayashi and Ichiro Matsuoka
    Citation: Genes and Environment 2015 37:10