Skip to main content


World AIDS Day 2013

1st December every year is World AIDS Day, and it is an opportunity not only to raise awareness of the disease, but to highlight the progress made by scientists and clinicians around the world to understand and find ways to cure the disease.

Over 30 years have passed since the discovery of HIV/AIDS, and in that time, there have been strong advancements in our understanding of HIV and AIDS and the development of potential therapeutics.

The articles below showcase the breadth and high caliber of the AIDS and HIV research published in our open access journals AIDS Research & Therapy, BMC Infectious Diseases, Retrovirology and Virology Journal.

  1. Content type: Review

    Despite the huge clinical success of antiretroviral therapy, several factors such as side effects, requirement of life-long adherence, high cost, incomplete access to therapies and development of drug resistan...

    Authors: Iart Luca Shytaj and Andrea Savarino

    Citation: Retrovirology 2013 10:145

    Published on:

  2. Content type: Research article

    HIV transmitted drug resistance (TDR) surveillance is usually conducted by sampling from a large population. However, overall TDR prevalence results may be inaccurate for many individual clinical setting. We a...

    Authors: James I Brooks, Harrison Niznick, Marianna Ofner, Harriet Merks and Jonathan B Angel

    Citation: BMC Infectious Diseases 2013 13:509

    Published on:

  3. Content type: Research article

    Reducing mortality from HIV-associated tuberculosis (TB) requires diagnostic tools that are rapid and have high sensitivity among patients with poor prognosis. We determined the relationship between disease se...

    Authors: Stephen D Lawn, Andrew D Kerkhoff, Monica Vogt and Robin Wood

    Citation: BMC Medicine 2013 11:231

    Published on:

  4. Content type: Research article

    The most severe HIV epidemics worldwide occur in Lesotho, Botswana and Swaziland. Here we focus on the Lesotho epidemic, which has received little attention. We determined the within-country heterogeneity in t...

    Authors: Brian J Coburn, Justin T Okano and Sally Blower

    Citation: BMC Medicine 2013 11:224

    Published on:

  5. Content type: Research article

    Antiretroviral therapy (ART) scale-up in resource-limited countries, with limited capacity for CD4 and HIV viral load monitoring, presents a unique challenge. We determined the effectiveness of first-line ART ...

    Authors: Oliver Barry, Jonathan Powell, Lorna Renner, Evelyn Y Bonney, Meghan Prin, William Ampofo, Jonas Kusah, Bamenla Goka, Kwamena WC Sagoe, Veronika Shabanova and Elijah Paintsil

    Citation: BMC Infectious Diseases 2013 13:476

    Published on:

  6. Content type: Research article

    The aim of our work was to evaluate the potential impact of the European policy of testing for HIV all individuals presenting with an indicator disease, to prevent late diagnosis of HIV. We report on a retrosp...

    Authors: Paola Scognamiglio, Giacomina Chiaradia, Gabriella De Carli, Massimo Giuliani, Claudio Maria Mastroianni, Stefano Aviani Barbacci, Anna Rita Buonomini, Susanna Grisetti, Alessandro Sampaolesi, Angela Corpolongo, Nicoletta Orchi, Vincenzo Puro, Giuseppe Ippolito and Enrico Girardi

    Citation: BMC Infectious Diseases 2013 13:473

    Published on:

  7. Content type: Research

    HIV trans-activator protein (Tat) is the crucial factor to control HIV transcription, and is usually considered as an important immunogen for the design of HIV vaccine. Recent studies reported some special bio...

    Authors: Ye Liu, Fusheng Li, Zhi Qi, Yanling Hao, Kunxue Hong, Yong Liu, Yulong Cong and Yiming Shao

    Citation: Virology Journal 2013 10:297

    Published on:

  8. Content type: Research

    Increasing rates of non-AIDS defining illnesses, and in particular liver diseases, have been found after the initiation of highly active antiretroviral therapy. However, there is little evidence concerning the...

    Authors: Thep Chalermchai, Narin Hiransuthikul, Pisit Tangkijvanich, Suteeraporn Pinyakorn, Anchalee Avihingsanon and Jintanat Ananworanich

    Citation: AIDS Research and Therapy 2013 10:21

    Published on:

  9. Content type: Research

    HIV/TB coinfection remains a major challenge even after the initiation of HAART. Little is known about Mycobacterium tuberculosis (Mtb) specific immune restoration in relation to immunologic and virologic outcome...

    Authors: Desta Kassa, Gebremedhin Gebremichael, Yodit Alemayehu, Dawit Wolday, Tsehaynesh Messele and Debbie van Baarle

    Citation: AIDS Research and Therapy 2013 10:18

    Published on:

  10. Content type: Research article

    This study assess knowledge, attitudes, and practices regarding Human Immunodeficiency Virus (HIV) testing and counseling services and the predictor characteristics of these outcomes among individuals who pres...

    Authors: Gabriella Di Giuseppe, Alessandra Sessa, Silvana Mollo, Natascia Corbisiero and Italo F Angelillo

    Citation: BMC Infectious Diseases 2013 13:277

    Published on:

  11. Content type: Debate

    Strategies for use of antiretroviral therapy (ART) have traditionally focused on providing treatment to persons who stand to benefit immediately from initiating the therapy. There is global consensus that any ...

    Authors: Jens D Lundgren, Abdel G Babiker, Fred M Gordin, Álvaro H Borges and James D Neaton

    Citation: BMC Medicine 2013 11:148

    Published on:

  12. Content type: Debate

    The debate regarding ‘When to Start’ antiretroviral therapy has raged since the introduction of zidovudine in 1987. Based on the entry criteria for the original Burroughs Wellcome 002 study, the field has been...

    Authors: Ricardo A Franco and Michael S Saag

    Citation: BMC Medicine 2013 11:147

    Published on:

  13. Content type: Research article

    Adherence to antiretroviral treatment is critical for suppression of viral replication, reduced destruction of CD4 cells, prevention of viral resistance, promotion of immune reconstitution and slowed disease prog...

    Authors: Negassie Berhe, Desalegn Tegabu and Mekuriaw Alemayehu

    Citation: BMC Infectious Diseases 2013 13:233

    Published on:

  14. Content type: Research

    Despite the increasingly wider availability of antiretroviral therapy (ART), some people living with HIV (PLHIV) and eligible for treatment have opted to adopt self-care practices thereby risking early AIDS-re...

    Authors: Maurice Musheke, Virginia Bond and Sonja Merten

    Citation: AIDS Research and Therapy 2013 10:12

    Published on:

  15. Content type: Research

    Lymphocyte Function-Associated Antigen-1 (LFA-1) likely plays a role in the pathogenesis of against HIV-1 and is known to facilitate cell-to-cell transmission of the virus. A monoclonal antibody specific for L...

    Authors: Jenna Rychert, Lindsay Jones, Graham McGrath, Sue Bazner and Eric S Rosenberg

    Citation: Virology Journal 2013 10:120

    Published on:

  16. Content type: Research

    This manuscript describes the development of a novel synthetic immunotherapy (HIV-v) composed of four multi-epitope polypeptides targeting conserved regions in the Nef, Rev, Vif and Vpr viral proteins. Immunog...

    Authors: Olga Pleguezuelos, Gregory A Stoloff and Wilson Caparrós-Wanderley

    Citation: Virology Journal 2013 10:107

    Published on: