The interplay between vascular mechanisms and headache, especially migraine, has long navigated through a sea of intricate and sometimes contradictory research findings, crafting a narrative that intertwines the serenity of clear connections with the tempest of unresolved queries. In this article Collection, we cordially invite researchers and clinicians to sail with us into an exploration of "Vascular Triggers of Headache", in which we shall embark on a journey through the vasculature and its posited roles, shedding light on known territories and voyaging into the unexplored.
The intricate tapestry of vascular causes associated with headache is rich, yet not fully unraveled. Migraine, an enigmatic and multifaceted neurological disorder, has historically been enshrouded in vascular theories, with early hypotheses anchoring its pathophysiology to cerebral vasodilation. Conversely, contemporary research has somewhat diverted from this stringent vascular focus, steering towards neuronal and neurovascular platforms. A divergence that inevitably sparks the debate: Is migraine predominantly a vascular disorder? We invite scholarly debates that weigh anchor in evidence and conjecture alike, providing a balanced scrutiny into this age-old question and its concomitant hypotheses. Comprehensive reviews that delve into vascular culprits such as cranial or cervical artery dissections, cerebral microemboli, patent foramen ovale (PFO), reversible cerebral vasoconstriction syndrome (RCVS), and other vasculopathies (both genetic and acquired) will serve to both illuminate and question our current understanding, unearthing new questions and pathways for exploration.
Further, we welcome original research articles that puncture through the current membrane of knowledge regarding the vascular mechanisms and headache. Innovative methodologies, exploratory studies, and research that breeches into new channels of understanding are particularly encouraged.
Through this article Collection, we endeavor to create a confluence of ideas, knowledge, and curiosity. While the vascular mechanisms underlying headache and migraine remain an enigma, enveloped in a fog of partial understanding, this compilation aims to gather a fleet of scientific minds to dispel the mist and navigate towards enlightenment.