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Ubiquitin Biology and Human Health

Edited by:
Andy T. Y. Lau, PhD, Shantou University Medical College, China
Amy Yan-Ming Xu, PhD, Shantou University Medical College, China

Submission Status: Closed

This collection is no longer accepting submissions.


Cancer Cell International is presenting the Collection on 'Ubiquitin Biology and Human Health.' The aim of this collection is to gather the latest knowledge and perspectives regarding ubiquitin research. 

This is an invite-only collection. 

  1. Gastric cancer is a highly prevalent cancer type and the underlying molecular mechanisms are not fully understood. Ubiquitin-specific peptidase (USP) 29 has been suggested to regulate cell fate in several type...

    Authors: Rongfu Tu, Ye Kang, Yiwen Pan, Yanyan Da, Doudou Ren, Ru Zhang, Zeqiong Cai, Yijia Liu, Jiao Xu, Junpeng Ma, Zhiyong Zhou, Shupeng Yin, Xiaozhuang Li, Peng Zhang, Qi Zhang, Jingchao Wang…
    Citation: Cancer Cell International 2024 24:33
    Content type: Research Published on:

  2. Bladder cancer is the second most common genitourinary malignancy worldwide. The death rate of bladder cancer has increased every year. However, the molecular mechanism of bladder cancer is not sufficiently st...

    Authors: Hui-hui Zhang, An-qi Zhang, Peng Peng, Liang Huang, Cai-ying Liu, Xin-rui Nie, De-fu Hou, Xia Zhang and Shang-ze Li
    Citation: Cancer Cell International 2024 24:32
    Content type: Research Published on:

  3. Myosin heavy chain 9 (MYH9) plays an important role in a number of diseases. Nevertheless, the function of MYH9 in glioma is unclear. The present research aimed to investigate the role of MYH9 in glioma and de...

    Authors: Zigui Chen, Xin Yan, Changfeng Miao, Longyang Liu, Su Liu, Ying Xia, Weiyi Fang, Dandan Zheng and Qisheng Luo
    Citation: Cancer Cell International 2023 23:220
    Content type: Research Published on:

  5. Nuclear factor-ĸB (NF-ĸB) is an important transcriptional regulator of key cellular processes, including cell cycle, immune response, and malignant transformation. We found that the ubiquitin ligase Kip1 ubiqu...

    Authors: Yelena Kravtsova-Ivantsiv, Gilad Goldhirsh, Ciprian Tomuleasa, Eli Pikarsky and Aaron Ciechanover
    Citation: Cancer Cell International 2023 23:67
    Content type: Review Published on:

About the collection

Cancer Cell International is presenting the Collection on 'Ubiquitin Biology and Human Health.' 

What makes ubiquitin biology so exciting and fascinating within biomedical science in the past few decades are the biochemical behaviors that allow ubiquitylation/deubiquitylation to modulate diverse processes of life. The growing lists of ubiquitin linkage types (monoubiquitylation, multi-monoubiquitylation, or homotypic/heterotypic polyubiquitylation), ubiquitin conjugation systems, and deubiquitylation enzymes have driven the curiosity of scientists to gradually reveal the complex realm between ubiquitin machinery and its dysregulation in various human diseases including cancer.

This year marks the 19th anniversary of the Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation. We are honored to have the first kickoff article in this thematic series by Professor Aaron Ciechanover, Nobel Prize laureate in Chemistry of 2004. This collection will also comprise articles from other scientists of the field; the goal is to gather the latest knowledge and perspectives regarding ubiquitin research.

This is an invite-only collection. 

Image credit: © selvanegra / Getty Images / iStock