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PD progresses in recent 10 years: from hypothesis to therapeutic targets

Edited by Shengdi Chen

A thematic series in Translational Neurodegeneration. 

  1. Aberrant aggregation of α-synuclein (α-syn) is a key pathological feature of Parkinson’s disease (PD), but the precise role of intestinal α-syn in the progression of PD is unclear. In a number of genetic Drosophi...

    Authors: Wei Liu, Kah-Leong Lim and Eng-King Tan
    Citation: Translational Neurodegeneration 2022 11:44
    Content type: Research Published on:

  2. The ultimate goal in Parkinson's disease (PD) research remains the identification of treatments that are capable of slowing or even halting the progression of the disease. The failure of numerous past disease-...

    Authors: Philipp Mahlknecht, Kathrin Marini, Mario Werkmann, Werner Poewe and Klaus Seppi
    Citation: Translational Neurodegeneration 2022 11:11
    Content type: Review Published on:

  3. Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are one of the most frequent genetic causes of both familial and sporadic Parkinson’s disease (PD). Mounting evidence has demonstrated pathological simil...

    Authors: Eunice Eun Seo Chang, Philip Wing-Lok Ho, Hui-Fang Liu, Shirley Yin-Yu Pang, Chi-Ting Leung, Yasine Malki, Zoe Yuen-Kiu Choi, David Boyer Ramsden and Shu-Leong Ho
    Citation: Translational Neurodegeneration 2022 11:10
    Content type: Review Published on:

  4. Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent two most common genetic causes of Parkinson’s disease (PD). Both genes are important in the autophagic-lysosomal pathway (A...

    Authors: Shirley Yin-Yu Pang, Rachel Cheuk Nam Lo, Philip Wing-Lok Ho, Hui-Fang Liu, Eunice Eun Seo Chang, Chi-Ting Leung, Yasine Malki, Zoe Yuen-Kiu Choi, Wing Yan Wong, Michelle Hiu-Wai Kung, David Boyer Ramsden and Shu-Leong Ho
    Citation: Translational Neurodegeneration 2022 11:5
    Content type: Review Published on: