Skip to main content


Trauma-induced coagulopathy and critical bleeding

Edited by Professor Shigeki Kushimoto

This thematic series was published in Journal of Intensive Care

Hemorrhage is the most important contributing factor of acute-phase mortality in trauma patients. During the last 10 years, there has been a dramatic evolution in our understanding of trauma-induced coagulopathy. For example, trauma itself and traumatic shock-induced endogenous coagulopathy are both referred to as acute traumatic coagulopathy (ATC) and multifactorial trauma-associated coagulation impairment. Alongside these understandings, a widespread paradigm shift in the resuscitation of critically injured patients has been observed. Understanding the pathophysiology of trauma-induced coagulopathy and novel therapeutic strategies are therefore vitally important issues for the management of patients with severe trauma.

  1. Review

    Tranexamic acid and trauma-induced coagulopathy

    Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits fibrinolysis by blocking the interaction of plasminogen with the lysine residues of fibrin. Historically, TXA is commonly ...

    Takeshi Nishida, Takahiro Kinoshita and Kazuma Yamakawa

    Journal of Intensive Care 2017 5:5

    Published on: 20 January 2017

  2. Review

    Dynamics of fibrinogen in acute phases of trauma

    Fibrinogen is a unique precursor of fibrin and cannot be compensated for by other coagulation factors. If plasma fibrinogen concentrations are insufficient, hemostatic clots cannot be formed with the appropria...

    Mineji Hayakawa

    Journal of Intensive Care 2017 5:3

    Published on: 20 January 2017