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Trauma-induced coagulopathy and critical bleeding

Edited by Professor Shigeki Kushimoto

This thematic series was published in Journal of Intensive Care

Hemorrhage is the most important contributing factor of acute-phase mortality in trauma patients. During the last 10 years, there has been a dramatic evolution in our understanding of trauma-induced coagulopathy. For example, trauma itself and traumatic shock-induced endogenous coagulopathy are both referred to as acute traumatic coagulopathy (ATC) and multifactorial trauma-associated coagulation impairment. Alongside these understandings, a widespread paradigm shift in the resuscitation of critically injured patients has been observed. Understanding the pathophysiology of trauma-induced coagulopathy and novel therapeutic strategies are therefore vitally important issues for the management of patients with severe trauma.

  2. Achieving a balance between organ perfusion and hemostasis is critical for optimal fluid resuscitation in patients with severe trauma. The concept of “permissive hypotension” refers to managing trauma patients...

    Authors: Daisuke Kudo, Yoshitaro Yoshida and Shigeki Kushimoto
    Citation: Journal of Intensive Care 2017 5:11
    Content type: Review Published on:

  5. Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits fibrinolysis by blocking the interaction of plasminogen with the lysine residues of fibrin. Historically, TXA is commonly ...

    Authors: Takeshi Nishida, Takahiro Kinoshita and Kazuma Yamakawa
    Citation: Journal of Intensive Care 2017 5:5
    Content type: Review Published on:

  7. Fibrinogen is a unique precursor of fibrin and cannot be compensated for by other coagulation factors. If plasma fibrinogen concentrations are insufficient, hemostatic clots cannot be formed with the appropria...

    Authors: Mineji Hayakawa
    Citation: Journal of Intensive Care 2017 5:3
    Content type: Review Published on: