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Tailored Implementation for Chronic Diseases

New Content ItemThis article collection reports on the Tailored Implementation for Chronic Diseases (TICD) project. The TICD project developed and tested programs to improve healthcare for patients with chronic diseases in five European countries, and examined methods for tailoring such programs to target groups and settings. Read the introduction to the project here.

The Tailored Implementation for Chronic Diseases project is funded by the European Community under its Framework 7 program. This collection of articles has undergone each journal’s standard peer review process.

Collection published in: Implementation Science, Trials, International Journal of Mental Health Systems, and BMC Family Practice.


  1. Research

    A tailored programme to implement recommendations for multimorbid patients with polypharmacy in primary care practices—process evaluation of a cluster randomized trial

    We developed and evaluated a tailored programme to implement three evidence-based recommendations for multimorbid patients with polypharmacy into primary care practices: structured medication counselling inclu...

    Cornelia Jäger, Jost Steinhäuser, Tobias Freund, Sarah Kuse, Joachim Szecsenyi and Michel Wensing

    Implementation Science 2017 12:31

    Published on: 6 March 2017

  2. Research

    Impact of a tailored program on the implementation of evidence-based recommendations for multimorbid patients with polypharmacy in primary care practices—results of a cluster-randomized controlled trial

    Multimorbid patients receiving polypharmacy represent a growing population at high risk for negative health outcomes. Tailoring is an approach of systematic intervention development taking account of previousl...

    Cornelia Jäger, Tobias Freund, Jost Steinhäuser, Christian Stock, Johannes Krisam, Petra Kaufmann-Kolle, Michel Wensing and Joachim Szecsenyi

    Implementation Science 2017 12:8

    Published on: 13 January 2017

  3. Research

    Process evaluation of five tailored programs to improve the implementation of evidence-based recommendations for chronic conditions in primary care

    Although there is evidence that tailored implementation strategies can be effective, there is little evidence on which methods of tailoring improve the effect. We designed and evaluated five tailored programs ...

    C. Jäger, J. Steinhäuser, T. Freund, R. Baker, S. Agarwal, M. Godycki-Cwirko, A. Kowalczyk, E. Aakhus, I. Granlund, J. van Lieshout, J. Szecsenyi and M. Wensing

    Implementation Science 2016 11:123

    Published on: 13 September 2016

  4. Research

    Cluster randomised trial of a tailored intervention to improve the management of overweight and obesity in primary care in England

    Tailoring is a frequent component of approaches for implementing clinical practice guidelines, although evidence on how to maximise the effectiveness of tailoring is limited. In England, overweight and obesity...

    Jane Goodfellow, Shona Agarwal, Fawn Harrad, David Shepherd, Tom Morris, Arne Ring, Nicola Walker, Stephen Rogers and Richard Baker

    Implementation Science 2016 11:77

    Published on: 27 May 2016

  5. Research

    A tailored intervention to implement guideline recommendations for elderly patients with depression in primary care: a pragmatic cluster randomised trial

    Elderly patients with depression are underdiagnosed, undertreated and run a high risk of a chronic course. General practitioners adhere to clinical practice guidelines to a limited degree. In the international...

    Eivind Aakhus, Ingeborg Granlund, Jan Odgaard-Jensen, Andrew D. Oxman and Signe A. Flottorp

    Implementation Science 2016 11:32

    Published on: 9 March 2016

  6. Research article

    Perceived determinants of cardiovascular risk management in primary care: disconnections between patient behaviours, practice organisation and healthcare system

    Although conditions for high quality cardiovascular risk management in primary care in the Netherlands are favourable, there still remains a gap between practice guideline recommendations and practice. The aim...

    E. Huntink, M. Wensing, M. A. Klomp and J. van Lieshout

    BMC Family Practice 2015 16:179

    Published on: 15 December 2015

  7. Research

    Tailoring interventions to implement recommendations for the treatment of elderly patients with depression: a qualitative study

    To improve adherence to evidence-based recommendations, it is logical to identify determinants of practice and tailor interventions to address these. We have previously prioritised six recommendations to impro...

    Eivind Aakhus, Ingeborg Granlund, Andrew D. Oxman and Signe A. Flottorp

    International Journal of Mental Health Systems 2015 9:36

    Published on: 12 September 2015

  8. Research

    Stakeholders’ contributions to tailored implementation programs: an observational study of group interview methods

    Tailored strategies to implement evidence-based practice can be generated in several ways. In this study, we explored the usefulness of group interviews for generating these strategies, focused on improving he...

    Elke Huntink, Jan van Lieshout, Eivind Aakhus, Richard Baker, Signe Flottorp, Maciek Godycki-Cwirko, Cornelia Jäger, Anna Kowalczyk, Joachim Szecsenyi and Michel Wensing

    Implementation Science 2014 9:185

    Published on: 6 December 2014

  9. Research

    Identifying determinants of care for tailoring implementation in chronic diseases: an evaluation of different methods

    The tailoring of implementation interventions includes the identification of the determinants of, or barriers to, healthcare practice. Different methods for identifying determinants have been used in implement...

    Jane Krause, Jan Van Lieshout, Rien Klomp, Elke Huntink, Eivind Aakhus, Signe Flottorp, Cornelia Jaeger, Jost Steinhaeuser, Maciek Godycki-Cwirko, Anna Kowalczyk, Shona Agarwal, Michel Wensing and Richard Baker

    Implementation Science 2014 9:102

    Published on: 12 August 2014

  10. Study protocol

    Evaluation of a tailored implementation strategy to improve the management of patients with chronic obstructive pulmonary disease in primary care: a study protocol of a cluster randomized trial

    Chronic obstructive pulmonary disease (COPD) remains a major health problem, strongly related to smoking. Despite the publication of practice guidelines on prevention and treatment, not all patients with the d...

    Maciek Godycki-Cwirko, Izabela Zakowska, Katarzyna Kosiek, Michel Wensing, Jaroslaw Krawczyk and Anna Kowalczyk

    Trials 2014 15:109

    Published on: 4 April 2014

  11. Methodology

    Tailored Implementation for Chronic Diseases (TICD): a protocol for process evaluation in cluster randomized controlled trials in five European countries

    In the ‘Tailored Implementation for Chronic Diseases (TICD)’ project, five tailored implementation programs to improve healthcare delivery in different chronic conditions have been developed. These programs wi...

    Cornelia Jäger, Tobias Freund, Jost Steinhäuser, Eivind Aakhus, Signe Flottorp, Maciek Godycki-Cwirko, Jan van Lieshout, Jane Krause, Joachim Szecsenyi and Michel Wensing

    Trials 2014 15:87

    Published on: 21 March 2014

  12. Study protocol

    Evaluation of a tailored intervention to improve management of overweight and obesity in primary care: study protocol of a cluster randomised controlled trial

    In the UK around 22% of men and 24% of women are obese, and there are varying but worrying levels in other European countries. Obesity is a chronic condition that carries an important health risk. National gui...

    Jane Krause, Shona Agarwal, Danielle H Bodicoat, Arne Ring, David Shepherd, Stephen Rogers, Michel Wensing and Richard Baker

    Trials 2014 15:82

    Published on: 19 March 2014

  13. Study protocol

    Tailored interventions to implement recommendations for elderly patients with depression in primary care: a study protocol for a pragmatic cluster randomised controlled trial

    The prevalence of depression is high and the elderly have an increased risk of developing chronic course. International data suggest that depression in the elderly is under-recognised, the latency before clini...

    Eivind Aakhus, Ingeborg Granlund, Jan Odgaard-Jensen, Michel Wensing, Andrew D Oxman and Signe A Flottorp

    Trials 2014 15:16

    Published on: 9 January 2014

  14. Study protocol

    Effectiveness of a tailored intervention to improve cardiovascular risk management in primary care: study protocol for a randomised controlled trial

    Cardiovascular disease (CVD) is an important worldwide cause of mortality. In The Netherlands, CVD is the leading cause of death for women and the second cause of death for men. Recommendations for diagnosis a...

    Elke Huntink, Naomi Heijmans, Michel Wensing and Jan van Lieshout

    Trials 2013 14:433

    Published on: 17 December 2013

  15. Study protocol

    A tailored implementation intervention to implement recommendations addressing polypharmacy in multimorbid patients: study protocol of a cluster randomized controlled trial

    Multimorbid patients frequently receive complex medication regimens and are at higher risk for adverse drug reactions and hospitalisations. Managing patients with polypharmacy is demanding, because it requires...

    Cornelia Jäger, Tobias Freund, Jost Steinhäuser, Stefanie Joos, Michel Wensing and Joachim Szecsenyi

    Trials 2013 14:420

    Published on: 5 December 2013

  16. Systematic review

    A checklist for identifying determinants of practice: A systematic review and synthesis of frameworks and taxonomies of factors that prevent or enable improvements in healthcare professional practice

    Determinants of practice are factors that might prevent or enable improvements. Several checklists, frameworks, taxonomies, and classifications of determinants of healthcare professional practice have been pub...

    Signe A Flottorp, Andrew D Oxman, Jane Krause, Nyokabi R Musila, Michel Wensing, Maciek Godycki-Cwirko, Richard Baker and Martin P Eccles

    Implementation Science 2013 8:35

    Published on: 23 March 2013

  17. Study protocol

    Tailored implementation for chronic diseases (TICD): A project protocol

    The assumption underlying tailoring is that implementation interventions are most helpful if these effectively address the most important determinants of practice for improvement in the targeted setting. The a...

    Michel Wensing, Andy Oxman, Richard Baker, Maciek Godycki-Cwirko, Signe Flottorp, Joachim Szecsenyi, Jeremy Grimshaw and Martin Eccles

    Implementation Science 2011 6:103

    Published on: 7 September 2011

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