Genome Medicine is calling for submissions to a new Collection on the tumor immune contexture.
The complex interplay between tumor cells and the immune system during cancer initiation, development, growth, and metastasis has been elucidated in recent years culminating in the concept of the tumor immune contexture, described as the spatial organization and density of immune cell types within the microenvironment which can be associated with patient prognosis and clinical outcome. Progress in the characterization of the tumor immune contexture has been accelerated by new techniques including single-cell sequencing and spatial transcriptomics which have unraveled the roles of different immune cell-types in cancer progression. In parallel, the development of immunotherapies targeting and manipulating the immune system to treat cancer such as immune checkpoint therapy, chimeric monoclonal antibodies, CAR T cells, oncolytic viruses, and cancer vaccines have revolutionized precision medicine. In the clinic, advances have been made in combining these immunotherapies with classical cancer therapy to treat patients of all cancer types, holding great promise for the future.
To capture advances in this growing area, Genome Medicine is pleased to announce a call for papers for our upcoming Collection on “Tumor immune contexture in cancer progression and treatment” guest edited by Noel De Miranda of Leiden University Medical Centre, the Netherlands. This Collection seeks to capture recent insights in characterizing and mapping the tumor immune contexture, dissecting response to immunotherapy, exploring anti-tumor immune responses, and uncovering parameters of the tumor immune contexture associated with patient outcomes, highlighting the clinical applications of these advances.
We are now inviting the submission of Research, Method, Software, Database and Guideline manuscripts of outstanding interest covering the breadth of the immune contexture from biological characterization to clinical applications, including but not limited to the following topics:
• Immune profiling and immunophenotypes
• Single-cell and multi-omic profiling
• Immune evasion
• Cancer stemness
• Immunity and metabolism
• T cell exhaustion
• Microbiome studies
• Neoantigens and immune response
• Hot and cold tumors
• Immunotherapy and combination therapy
• Therapy response, resistance, and residual disease
• Precision medicine and therapeutics
• Clinical trials
• CAR T cell therapy
• Longitudinal monitoring
• Liquid biopsies
• Interpretable machine learning
• Prognosis and outcome prediction
If you would like to enquire about the suitability of a manuscript for consideration in this Collection, please email firstname.lastname@example.org.
Image credit: Steve Gschmeissner / Science Photo Library