Guest Editors:
Helen Rowe: Queen Mary University of London, UK
Vincent Colot: Institut de Biologie de l'Ecole Normale Supérieure (IBENS), France
Mobile DNA is calling for submissions to our Collection on "Transposable Elements as Epigenetic Agents of Development, Immunity, Phenotypic Variation and Disease". This is a sister Collection with Epigenetics of Mobile Elements.
Image credit: Anusorn / stock.adobe.com
Transposable elements (TEs) are mobile DNA sequences that invade genomes and contribute to genome innovation. Because TEs and the much more abundant degenerate copies of them that accumulate over evolutionary time scales are subject to epigenetic control, they can also exert a multitude of effects on genome function, from regulation of gene expression, to shaping the dynamics of chromatin architecture or inducing innate and adaptive immune responses. The dysregulation of this epigenetic control has notably been implicated in cancer, autoimmune diseases and ageing in humans, as well as in the generation of heritable epimutations in plants.
This Collection will focus on the epigenetic mechanisms targeting TE sequences and the functional consequences of this targeting, with the aim to provide answers to the following questions:
• How do TE sequences regulate developmental processes including gene expression and cell fate transitions?
• How do TE sequences affect the three-dimensional structure of chromatin, and what are the consequences of these changes for genome function?
• How are TE sequences controlled epigenetically during the life cycle and how do they contribute to ageing?
• When and how do TE sequences drive or potentiate immune responses?
• What is the role of epigenetic dysregulation of TE sequences in phenotypic variation and in diseases such as cancer and neurodegenerative disease?
• Can targeting TE sequences with epidrugs or epigenome editing represent a therapeutic strategy?
Moloney murine leukemia virus (MLV) replication is suppressed in mouse embryonic stem cells (ESCs) by the Trim28-SETDB1 complex. The chromatin remodeler Smarcad1 interacts with Trim28 and was suggested to allo...
Despite their origins as selfish parasitic sequences, some transposons in the human genome have been co-opted to serve as regulatory elements, contributing to the evolution of transcriptional networks. Most we...
This Collection welcomes submission of original Research Articles and Reviews. Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal. Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select "Transposable Elements as Epigenetic Agents of Development, Immunity, Phenotypic Variation and Disease" from the dropdown menu.
Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.
The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests.