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Current Evidence and Future Directions in the Treatment of Colorectal Cancer

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  1. For sigmoid colon or rectal cancer, a definite consensus regarding the optimal level ligating the inferior mesenteric artery (IMA) has not been reached. We performed this study to determine whether the ligatio...

    Authors: Yawei Wang, Yan Wang, Liaonan Zou, Lingna Deng, Tianchong Wu, Linsen Liu, Jiling Jiang and Tailai An
    Citation: World Journal of Surgical Oncology 2022 20:274
  2. To investigate the effect and clinical significance of different thoracic surgical approaches for patients with stage IIB–IVA esophageal squamous cell carcinoma on the survival and prognosis of postoperative r...

    Authors: Mingcheng Gao, Yulin Zhu, Yan Gu, Zhan Shi, Jixiang Wu, Huiwen Chang and Jianxiang Song
    Citation: World Journal of Surgical Oncology 2022 20:271
  3. Few studies have evaluated the feasibility and safety of intracorporeal anastomosis (IA) for left hemicolectomy. Here, we aimed to investigate the potential advantages and disadvantages of laparoscopic left he...

    Authors: Li-Ming Wang, Bor-Kang Jong, Chun-Kai Liao, Ya-Ting Kou, Yih-Jong Chern, Yu-Jen Hsu, Pao-Shiu Hsieh, Wen-Sy Tsai and Jeng-Fu You
    Citation: World Journal of Surgical Oncology 2022 20:270
  4. Cutaneous melanoma (CM) is a skin cancer that is highly metastatic and aggressive, with a dismal prognosis. This is the first study to use inflammatory response-related genes to build a model and evaluate thei...

    Authors: Jiahua Xing, Yan Li, Youbai Chen and Yan Han
    Citation: World Journal of Surgical Oncology 2022 20:263
  5. To date, the optimal treatment for potentially resectable metastatic colorectal cancer (mCRC) patients has yet to be determined. Encouraging results have been reported in studies exploring the efficacy of trip...

    Authors: Qian Wu, Huan Wang, Suqin Zhang, Yifei Zeng, Wei Yang, Wenjun Pan, Guodai Hong and Wenbin Gao
    Citation: World Journal of Surgical Oncology 2022 20:258
  6. The morbidity and mortality of colorectal cancer (CRC) remain high, posing a serious threat to human life and health. The early diagnosis and prognostic evaluation of CRC are two major challenges in clinical p...

    Authors: Lin-Yao Cheng, Mao-sen Huang, Hua-Ge Zhong, Hai-Ming Ru, Si-Si Mo, Chun-Yin Wei, Zi-Jie Su, Xian-Wei Mo, Lin-Hai Yan and Wei-Zhong Tang
    Citation: World Journal of Surgical Oncology 2022 20:257
  7. Whether cytoreductive prostatectomy (CRP) should be performed in patients with oligometastatic prostate cancer (OPC) remains controversial. The goal of this systematic meta-analysis was to assess the efficacy ...

    Authors: Yifeng Mao, Mingqiu Hu, Gaowei Yang, Erke Gao and Wangwang Xu
    Citation: World Journal of Surgical Oncology 2022 20:255
  8. Prolonged air leak (PAL) remains one of the most frequent postoperative complications after pulmonary resection. This study aimed to develop a predictive nomogram to estimate the risk of PAL for individual pat...

    Authors: Rongyang Li, Mengchao Xue, Zheng Ma, Chenghao Qu, Kun Wang, Yu Zhang, Weiming Yue, Huiying Zhang and Hui Tian
    Citation: World Journal of Surgical Oncology 2022 20:249
  9. Pyroptosis and related gasdermin family proteins play an important role in the tumorigenesis of colorectal cancer (CRC). However, the prognostic roles of pyroptosis-related genes (PRGs) and their relation to i...

    Authors: Jun Hu, Caijuan Tian, Yanpeng Zhao, Yixian Guo and Shuo Chen
    Citation: World Journal of Surgical Oncology 2022 20:234
  10. We aimed to explore whether body mass index (BMI) and albumin were associated with overall survival (OS) in individuals who underwent pancreaticoduodenectomy (PD) for cancer.

    Authors: Lei Cui, Huiping Yu, Qingmei Sun, Yi Miao, Kuirong Jiang and Xiaoping Fang
    Citation: World Journal of Surgical Oncology 2022 20:221
  11. The standard treatment for locally advanced rectal cancer (LARC) is preoperative chemoradiotherapy (CRT) followed by surgery and adjuvant chemotherapy. However, it has been suggested that intensification of ne...

    Authors: Ryota Mori, Mamoru Uemura, Yuki Sekido, Tsuyoshi Hata, Takayuki Ogino, Hidekazu Takahashi, Norikatsu Miyoshi, Tsunekazu Mizushima, Yuichiro Doki and Hidetoshi Eguchi
    Citation: World Journal of Surgical Oncology 2022 20:166
  12. Preliminary study results demonstrated parenchyma-sparing surgery (PSS) as an effective approach which allowed to remove colorectal cancer (CRC) metastatic lesions within the central liver cites and increased ...

    Authors: A. A. Burlaka, D. E. Makhmudov, I. I. Lisnyi, A. V. Paliichuk, V. V. Zvirych and A. V. Lukashenko
    Citation: World Journal of Surgical Oncology 2022 20:122
  13. Colon adenocarcinoma (COAD) is one of the most common malignant tumors and is diagnosed at an advanced stage with a poor prognosis worldwide. Pyroptosis is involved in the initiation and progression of tumors....

    Authors: Yuying Tan, Liqing Lu, Xujun Liang and Yongheng Chen
    Citation: World Journal of Surgical Oncology 2022 20:118
  14. Ferroptosis is associated with the development of many cancers; the molecular features of colorectal carcinoma (CRC) based on ferroptosis-related genes (FRGs) remain unknown. Herein, we aimed to identify ferro...

    Authors: Qingfang Yue, Yuan Zhang, Fei Wang, Fei Cao, Xianglong Duan and Jun Bai
    Citation: World Journal of Surgical Oncology 2022 20:117
  15. The ten-eleven translocation 1 (TET1), which is essential for active DNA demethylation, plays a multifaceted role in the pathogenesis of colorectal cancer. The study has demonstrated the association of TET1 mutat...

    Authors: Tianzhu Qiu, Xiaoxuan Wang, Furong Du, Xiangjing Hu, Fujun Sun, Chao Song and Jie Zhao
    Citation: World Journal of Surgical Oncology 2022 20:115
  16. We evaluated the influence of infectious complications, particularly surgical site infection (SSI), on long-term oncological results after elective laparoscopic resection of colorectal cancer.

    Authors: Nana Sugamata, Takashi Okuyama, Emiko Takeshita, Haruka Oi, Yuhei Hakozaki, Shunya Miyazaki, Musashi Takada, Takashi Mitsui, Takuji Noro, Hideyuki Yoshitomi and Masatoshi Oya
    Citation: World Journal of Surgical Oncology 2022 20:111
  17. To investigate the learning curve of conformal sphincter preservation operation (CSPO) in the treatment of ultralow rectal cancer and to further explore the influencing factors of operation time.

    Authors: Hai-bo Ding, Lin-hui Wang, Ge Sun, Guan-yu Yu, Xian-hua Gao, Kuo Zheng, Hai-feng Gong, Jin-ke Sui, Xiao-ming Zhu and Wei Zhang
    Citation: World Journal of Surgical Oncology 2022 20:102
  18. The aim of this study was to evaluate the efficacy of lateral pelvic lymph node (LPN) dissection (LPND) for rectal cancer patients with LPN metastasis (LPNM) and investigate the impact of LPNM on prognosis.

    Authors: Sicheng Zhou, Yujuan Jiang, Jianwei Liang and Qian Liu
    Citation: World Journal of Surgical Oncology 2022 20:97
  19. Colon adenocarcinoma (COAD) is one of the common cancers worldwide. Collagen triple helix repeat containing 1 (CTHRC1) has been reported to be involved in cell invasion, angiogenesis, and the promotion of epit...

    Authors: Chuang Meng, Yue Zhang, Dujun Jiang and Jian Wang
    Citation: World Journal of Surgical Oncology 2022 20:89
  20. To develop and evaluate the prognostic value of a comprehensive inflammatory biomarker for postoperative colorectal cancer (CRC) patients.

    Authors: Xiaoling Cai, Fa Chen, Lisheng Liang, Weizhong Jiang, Xing Liu, Dong Wang, Yunli Wu, Jinyan Chen, Guoxian Guan and Xian-e Peng
    Citation: World Journal of Surgical Oncology 2022 20:79
  21. The operative results of different approaches for the laparoscopic intersphincteric resection (LAISR) of low rectal cancer vary, and the patient characteristics associated with the best outcomes for each proce...

    Authors: Wenquan Ou, Xiaohua Wu, Jinfu Zhuang, Yuanfeng Yang, Yiyi Zhang, Xing Liu and Guoxian Guan
    Citation: World Journal of Surgical Oncology 2022 20:43
  22. The purpose of this study was to explore the risk factors for synchronous liver metastasis (LM) of colorectal cancer (CRC) and to construct a nomogram for predicting the occurrence of synchronous LM based on b...

    Authors: Yunxiao Liu, Yuliuming Wang, Hao Zhang, Mingyu Zheng, Chunlin Wang, Zhiqiao Hu, Yang Wang, Huan Xiong, Hanqing Hu, Qingchao Tang and Guiyu Wang
    Citation: World Journal of Surgical Oncology 2022 20:39
  23. The enhanced recovery after surgery (ERAS) program expedites patient recovery after major surgery. This study aimed to investigate the role of the triad of procalcitonin (PCT), C-reactive protein (CRP), and wh...

    Authors: Haidi Abd El Zaher, Waleed M. Ghareeb, Ahmed M. Fouad, Khaled Madbouly, Hamada Fathy, Tomas Vedin, Marcus Edelhamre, Sameh H. Emile and Mohammed Faisal
    Citation: World Journal of Surgical Oncology 2022 20:33

    The Correction to this article has been published in World Journal of Surgical Oncology 2022 20:64

  24. Early detection of colorectal cancer (CRC) improves prognosis, yet many CRCs are diagnosed following symptoms. The aim of this study was to determine which CRC-related symptoms or signs can predict an advanced...

    Authors: Rotem Gvirtzman, Dan Meir Livovsky, Esther Tahover, Eran Goldin and Benjamin Koslowsky
    Citation: World Journal of Surgical Oncology 2021 19:341
  25. The prognosis of obstructive colorectal cancer (oCRC) is worse than that of nonobstructive colorectal cancer. However, no previous study has established an individualized prediction model for the prognosis of ...

    Authors: Jian Lv, Yuan yuan Liu, Yi tao Jia, Jing li He, Guang yao Dai, Peng Guo, Zhao long Zhao, Yan ni Zhang and Zhong xin Li
    Citation: World Journal of Surgical Oncology 2021 19:337
  26. Capecitabine is a prodrug that is enzymatically converted to its active form, fluorouracil (also called 5-fluorouracil), which is commonly used as adjuvant chemotherapy in colorectal cancer patients. Severe ga...

    Authors: You Zou, Shuang Liu, Jianhong Wu and Zhen Sun
    Citation: World Journal of Surgical Oncology 2021 19:332
  27. Rectal cancer, one of most common neoplasms, is characterized by an overall survival rate exceeding 60%. Nonetheless, local recurrence (LR) following surgery for rectal cancer remains a formidable clinical pro...

    Authors: Michal Jankowski, Wojciech M. Wysocki, Manuela Las-Jankowska, Karol Tkaczyński, Dorian Wiśniewski, Dariusz Bała and Wojciech Zegarski
    Citation: World Journal of Surgical Oncology 2021 19:308
  28. Colorectal cancer (CRC) is one of the most common cancers of the gastrointestinal tract and ranks third in cancer-related deaths worldwide. This study was conducted to identify novel biomarkers related to the ...

    Authors: Xuan Yang, Wangao Wei, Shisheng Tan, Linrui Guo, Song Qiao, Biao Yao and Zi Wang
    Citation: World Journal of Surgical Oncology 2021 19:248
  29. Placement of a self-expanding metal stent (SEMS) in patients presenting with an acute colorectal obstruction (ACO) may obviate emergency surgery (ES), potentially effectively palliating incurable tumors, actin...

    Authors: Fei-hu Yan, Yao Zhang, Cheng-ling Bian, Xiao-shuang Liu, Bing-chen Chen, Zhen Wang, Hao Wang, E. Ji-fu and En-da Yu
    Citation: World Journal of Surgical Oncology 2021 19:194
  30. Understanding the vascular anatomy is critical for performing central vascular ligation (CVL) in right hemicolectomy with complete mesocolic excision (CME). This study aimed to investigate the predictive value...

    Authors: Hui Yu, Yong Zhuang, Jinliang Jian and Chunkang Yang
    Citation: World Journal of Surgical Oncology 2021 19:189
  31. Postoperative symptomatic anastomotic leakage (AL) is a serious complication after low anterior resection (LAR) for rectal cancer. AL can potentially affect short-term patient outcomes and long-term prognosis....

    Authors: Xinyu Qi, Maoxing Liu, Kai Xu, Pin Gao, Fei Tan, Zhendan Yao, Nan Zhang, Hong Yang, Chenghai Zhang, Jiadi Xing, Ming Cui and Xiangqian Su
    Citation: World Journal of Surgical Oncology 2021 19:187
  32. Lymph node metastasis (LNM) is a risk factor for poor long-term outcomes and a prognostic factor for disease-free survival in colon cancer. Preoperative lymph node status evaluation remains a challenge. The pu...

    Authors: Anna Mou, Hang Li, Xiao-li Chen, Yang-hua Fan and Hong Pu
    Citation: World Journal of Surgical Oncology 2021 19:179
  33. Mistletoe extract, used as a complementary chemotherapeutic agent for cancer patients, has anticancer effects against various malignancies. The aim of the present study was to evaluate the effect of mistletoe ...

    Authors: Jeong-Heum Baek, Youngbae Jeon, Kyoung-Won Han, Dong Hae Jung and Kyung-Ok Kim
    Citation: World Journal of Surgical Oncology 2021 19:178
  34. Robot-assisted surgery is increasingly implemented for the resection of colorectal cancer, although the scientific evidence for adopting this technique is still limited. This study’s main objective was to comp...

    Authors: Pedja Cuk, Randi Maria Simonsen, Mirjana Komljen, Michael Festersen Nielsen, Per Helligsø, Andreas Kristian Pedersen, Christian Backer Mogensen and Mark Bremholm Ellebæk
    Citation: World Journal of Surgical Oncology 2021 19:155
  35. The main negative prognostic factors in patients with rectal cancer after radical treatment include regional lymph node involvement, lymphovascular invasion, and perineural invasion. However, some patients sti...

    Authors: Marcin Zeman, Marek Czarnecki, Ewa Chmielik, Adam Idasiak, Władysław Skałba, Mirosław Strączyński, Piotr J. Paul and Agnieszka Czarniecka
    Citation: World Journal of Surgical Oncology 2021 19:154
  36. The inflammatory biomarker “C-reactive protein to albumin ratio (CAR)” has been reported to significantly correlate to a variety of human cancers. However, there are conflicting results regarding the prognosti...

    Authors: Chun-Kai Liao, Yen-Lin Yu, Yueh-Chen Lin, Yu-Jen Hsu, Yih-Jong Chern, Jy-Ming Chiang and Jeng-Fu You
    Citation: World Journal of Surgical Oncology 2021 19:139
  37. Radiotherapy is a main therapeutic method for cancers, including colon cancer. In the current study, we aim to explore the effects of circular RNA (circRNA) circ_0055625 in the progression and radiosensitivity...

    Authors: Chao Gao, Yi Zhang, Yanming Tian, Chun Han, Lan Wang, Boyue Ding, Hua Tian, Chaoxi Zhou, Yingchao Ju, Ale Peng and Qiyao Yu
    Citation: World Journal of Surgical Oncology 2021 19:131
  38. Most previous studies compared survival between left-sided and right-sided colon cancer without adjustment for clinicopathological parameters. We investigated the effect of sidedness on survival among patients...

    Authors: Zhuang-Sheng Huang, Jun-Wei Wu, Ying Li, Yu-Hai Lin and Xu-Yuan Li
    Citation: World Journal of Surgical Oncology 2021 19:127
  39. Lymphovascular invasion (LVI) is defined as the presence of cancer cells in lymphatics or blood vessels. This study aimed to evaluate the prognostic value of LVI in stage II colorectal cancer (CRC) patients wi...

    Authors: Zhenyan Gao, Huihua Cao, Xiang Xu, Qing Wang, Yugang Wu and Qicheng Lu
    Citation: World Journal of Surgical Oncology 2021 19:125
  40. The Chinese Society of Clinical Oncology guidelines 2018 and the recent update of that (version 2020) recommends accurate examination before major treatment for decision(s) in cases of colon cancer. Also, the ...

    Authors: Yadong Zhou, Zhiwei Han, Fafu Dou and Tao Yan
    Citation: World Journal of Surgical Oncology 2021 19:120
  41. Colorectal cancer is one of the most common malignancy in the world. The oncogenesis of colorectal cancer is still not fully elucidated. It was reported that microRNA-490-3p (miR-490-3p) was closely related to...

    Authors: Jing Li, Rubing Mo and Linmei Zheng
    Citation: World Journal of Surgical Oncology 2021 19:117

    The Correction to this article has been published in World Journal of Surgical Oncology 2023 21:346

  42. Radical resection is associated with good prognosis among patients with cT1/T2Nx rectal cancer. However, still some of the patients experienced cancer recurrence following radical resection. This study tried t...

    Authors: I-Li Lai, Jeng-Fu You, Yih-Jong Chern, Wen-Sy Tsai, Jy-Ming Chiang, Pao-Shiu Hsieh, Hsin-Yuan Hung and Yu-Jen Hsu
    Citation: World Journal of Surgical Oncology 2021 19:116
  43. Colon cancer is a commonly worldwide cancer with high morbidity and mortality. Long non-coding RNAs (lncRNAs) are involved in many biological processes and are closely related to the occurrence of colon cancer...

    Authors: Meihong Gao, Yang Guo, Yifu Xiao and Xuequn Shang
    Citation: World Journal of Surgical Oncology 2021 19:104
  44. Hepatectomy for resectable colorectal liver metastasis (CRLM) is recommended. However, the efficacy of upfront hepatectomy without neoadjuvant chemotherapy (NAC) is unclear due to the uncertainty of perioperat...

    Authors: Kosuke Ono, Tomoyuki Abe, Akihiko Oshita, Yusuke Sumi, Takuya Yano, Hiroshi Okuda, Manabu Kurayoshi, Tsuyoshi Kobayashi, Hideki Ohdan, Toshio Noriyuki and Masahiro Nakahara
    Citation: World Journal of Surgical Oncology 2021 19:97
  45. Colorectal cancer is the third most common type of cancer in the world. We characterize a cohort of patients who survived up to 5 years without recurrence and identify factors predicting the probability of cure.

    Authors: Inge van den Berg, Robert R. J. Coebergh van den Braak, Jeroen L. A. van Vugt, Jan N. M. Ijzermans and Stefan Buettner
    Citation: World Journal of Surgical Oncology 2021 19:96

    The Correction to this article has been published in World Journal of Surgical Oncology 2021 19:159

  46. Lymph node metastasis is a major prognostic sign of colorectal carcinoma and an important indicator for individualized treatment. M2 macrophages play a key role in carcinogenesis and tumor development by enhan...

    Authors: Yanping Wang, Jikun Wang, Chunyu Yang, Yue Wang, Jinhao Liu, Zuoxiu Shi, Yanlei Chen, Yang Feng, Xueqian Ma and Shifeng Qiao
    Citation: World Journal of Surgical Oncology 2021 19:91