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Current Evidence and Future Directions in the Treatment of Colorectal Cancer

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  1. Perianal Paget’s disease (PPD) is an intraepithelial invasion of the perianal skin and is frequently associated with underlying anorectal carcinoma. The relatively rare nature of this disease has made it diffi...

    Authors: Jun Imaizumi, Konosuke Moritani, Yasuyuki Takamizawa, Manabu Inoue, Shunsuke Tsukamoto and Yukihide Kanemitsu
    Citation: World Journal of Surgical Oncology 2023 21:17
  2. Self-expanding metal stents (SEMS) served as a bridge to surgery (BTS). However, this method may be associated with worse long-term prognosis and relapse of CRC patients. Therefore, we attempted to clarify thi...

    Authors: Zhizhan Ni, Yuepeng Cao, Liming Liu, Chenshen Huang, Huahao Xie, Jinzhe Zhou, Bujun Ge and Qi Huang
    Citation: World Journal of Surgical Oncology 2023 21:1
  3. Renal cell carcinoma (RCC) with haemangioblastoma-like characteristics is a type of RCC reported in recent years. RCC with (angio) leiomyomatous stroma (RCCLMS) was included as a provisional entity of the 2016...

    Authors: Jixia Kong, Juan Tao, Qimin Wang, Qingfu Zhang and Liying Yin
    Citation: World Journal of Surgical Oncology 2022 20:395
  4. Pulmonary sarcomatoid carcinoma (PSC) is a rare and unconventional non-small-cell lung cancer (NSCLC) that appears to be aggressive, with a poor prognosis and response to conventional treatment. Approximately ...

    Authors: Ying Wu, Zhecheng Yan, Juan Pan, Xiaona Chang, Bo Huang, Danju Luo, Rui Meng, Heshui Shi, Jun Fan and Xiu Nie
    Citation: World Journal of Surgical Oncology 2022 20:386
  5. Remnant gastric cancer (RGC) has been increasing for various reasons such as a longer life span, medical progress, and others. It generally has a poor prognosis, and its mechanism of occurrence is unknown. The...

    Authors: Yoshihiko Kakiuchi, Satoru Kikuchi, Shinji Kuroda, Shunsuke Kagawa and Toshiyoshi Fujiwara
    Citation: World Journal of Surgical Oncology 2022 20:374
  6. In rectal cancer (RC) surgery, the complexity of total mesorectal excision (TME) in laparoscopic sphincter-preserving surgery (lap-SPS) for RC near the anus has been a critical issue. Recently, technical assis...

    Authors: Satoru Kagami, Kimihiko Funahashi, Takamaru Koda, Toshimitsu Ushigome, Tomoaki Kaneko, Takayuki Suzuki, Yasuyuki Miura, Yasuo Nagashima, Kimihiko Yoshida and Akiharu Kurihara
    Citation: World Journal of Surgical Oncology 2022 20:363
  7. To report long-term oncological outcomes and organ preservation rate with a chemoradiotherapy-consolidation chemotherapy (CRT-CNCT) treatment for locally advanced rectal cancer (LARC).

    Authors: Oktar Asoglu, Alisina Bulut, Vusal Aliyev, Guglielmo Niccolò Piozzi, Koray Guven, Barıs Bakır and Suha Goksel
    Citation: World Journal of Surgical Oncology 2022 20:358
  8. Robotic surgery has been widely used in the radical treatment of colonic cancer. However, it is unclear what advantages the robotic approach offers over other approaches in left colectomy. This study aims to e...

    Authors: Zhixiang Huang, Taiyuan Li, Genghua Zhang, Zhen Zhou, Haoran Shi, Cheng Tang, Lingling Yang and Xiong Lei
    Citation: World Journal of Surgical Oncology 2022 20:345
  9. The aim of this study was to develop comprehensive and effective nomograms for predicting overall survival (OS) and cancer-specific survival (CSS) rates in patients with colorectal mucinous adenocarcinoma (CRMA).

    Authors: Pengchao Wang, Qingyu Song, Ming Lu, Qingcheng Xia, Zijun Wang, Qinghong Zhao and Xiang Ma
    Citation: World Journal of Surgical Oncology 2022 20:330
  10. Preoperative absolute lymphocyte count (LC) and fibrinogen (FIB) are useful prognostic indicators in colorectal cancer (CRC). However, the prognostic value of the LC to FIB ratio (LFR) has never been addressed.

    Authors: Xiang Huang, Yu Huan, Long Liu, Qianwen Ye, Jian Guo and Bing Yan
    Citation: World Journal of Surgical Oncology 2022 20:309
  11. As transanal total mesorectal excision (taTME) is performed worldwide, the optimization of existing training and guidance programs to enhance new taTME learners’ competence in performing this procedure is warr...

    Authors: Fengming Xu, Yiqiao Zhang, Jiafu Yan, Bowen Xu, Guocong Wu, Zhengyang Yang, Liting Sun, Xiao Zhang, Hongwei Yao and Zhongtao Zhang
    Citation: World Journal of Surgical Oncology 2022 20:305
  12. Upregulation of Stathmin 1 (STMN1), a cytoplasmic phosphoprotein that controls the dynamics of cellular microtubules, is linked to malignant behavior and poor prognosis in a range of malignancies. However, lit...

    Authors: En-di Zhang, Chenxuan Li, Yuan Fang, Na Li, Zhongyun Xiao, Chuhong Chen, Benkai Wei, Hangping Wang, Jincheng Xie, Yinglei Miao, Zhong Zeng and Hanfei Huang
    Citation: World Journal of Surgical Oncology 2022 20:301
  13. An investigation of the effects of different types of the inferior mesenteric artery (IMA) on laparoscopic left colic artery (LCA) radical resection of rectal cancer was conducted.

    Authors: Jinghao Chen, Meirong Wang, Yuhao Chen, Suying Chen, Jing Xiao, Xiaole Fan, Jushun Yang and Bosheng He
    Citation: World Journal of Surgical Oncology 2022 20:292
  14. Currently, high or low ligation of the inferior mesenteric artery (IMA) is a controversial issue in laparoscopic radical surgery for colorectal cancer. High or low ligation of the IMA has both advantages and d...

    Authors: Shun Zeng, Wenhao Wu, Xianbin Zhang, Tong Qiu and Peng Gong
    Citation: World Journal of Surgical Oncology 2022 20:290
  15. Venous thromboembolism (VTE) is a threat to the prognosis of tumor patients, especially for critically ill patients. No uniform standard model of VTE risk for critically ill patients with tumors was formatted ...

    Authors: Ruqi Mei, Guodong Wang, Renxiong Chen and Hongzhi Wang
    Citation: World Journal of Surgical Oncology 2022 20:245
  16. For sigmoid colon or rectal cancer, a definite consensus regarding the optimal level ligating the inferior mesenteric artery (IMA) has not been reached. We performed this study to determine whether the ligatio...

    Authors: Yawei Wang, Yan Wang, Liaonan Zou, Lingna Deng, Tianchong Wu, Linsen Liu, Jiling Jiang and Tailai An
    Citation: World Journal of Surgical Oncology 2022 20:274
  17. To investigate the effect and clinical significance of different thoracic surgical approaches for patients with stage IIB–IVA esophageal squamous cell carcinoma on the survival and prognosis of postoperative r...

    Authors: Mingcheng Gao, Yulin Zhu, Yan Gu, Zhan Shi, Jixiang Wu, Huiwen Chang and Jianxiang Song
    Citation: World Journal of Surgical Oncology 2022 20:271
  18. Few studies have evaluated the feasibility and safety of intracorporeal anastomosis (IA) for left hemicolectomy. Here, we aimed to investigate the potential advantages and disadvantages of laparoscopic left he...

    Authors: Li-Ming Wang, Bor-Kang Jong, Chun-Kai Liao, Ya-Ting Kou, Yih-Jong Chern, Yu-Jen Hsu, Pao-Shiu Hsieh, Wen-Sy Tsai and Jeng-Fu You
    Citation: World Journal of Surgical Oncology 2022 20:270
  19. Cutaneous melanoma (CM) is a skin cancer that is highly metastatic and aggressive, with a dismal prognosis. This is the first study to use inflammatory response-related genes to build a model and evaluate thei...

    Authors: Jiahua Xing, Yan Li, Youbai Chen and Yan Han
    Citation: World Journal of Surgical Oncology 2022 20:263
  20. To date, the optimal treatment for potentially resectable metastatic colorectal cancer (mCRC) patients has yet to be determined. Encouraging results have been reported in studies exploring the efficacy of trip...

    Authors: Qian Wu, Huan Wang, Suqin Zhang, Yifei Zeng, Wei Yang, Wenjun Pan, Guodai Hong and Wenbin Gao
    Citation: World Journal of Surgical Oncology 2022 20:258
  21. The morbidity and mortality of colorectal cancer (CRC) remain high, posing a serious threat to human life and health. The early diagnosis and prognostic evaluation of CRC are two major challenges in clinical p...

    Authors: Lin-Yao Cheng, Mao-sen Huang, Hua-Ge Zhong, Hai-Ming Ru, Si-Si Mo, Chun-Yin Wei, Zi-Jie Su, Xian-Wei Mo, Lin-Hai Yan and Wei-Zhong Tang
    Citation: World Journal of Surgical Oncology 2022 20:257
  22. Whether cytoreductive prostatectomy (CRP) should be performed in patients with oligometastatic prostate cancer (OPC) remains controversial. The goal of this systematic meta-analysis was to assess the efficacy ...

    Authors: Yifeng Mao, Mingqiu Hu, Gaowei Yang, Erke Gao and Wangwang Xu
    Citation: World Journal of Surgical Oncology 2022 20:255
  23. Prolonged air leak (PAL) remains one of the most frequent postoperative complications after pulmonary resection. This study aimed to develop a predictive nomogram to estimate the risk of PAL for individual pat...

    Authors: Rongyang Li, Mengchao Xue, Zheng Ma, Chenghao Qu, Kun Wang, Yu Zhang, Weiming Yue, Huiying Zhang and Hui Tian
    Citation: World Journal of Surgical Oncology 2022 20:249
  24. Pyroptosis and related gasdermin family proteins play an important role in the tumorigenesis of colorectal cancer (CRC). However, the prognostic roles of pyroptosis-related genes (PRGs) and their relation to i...

    Authors: Jun Hu, Caijuan Tian, Yanpeng Zhao, Yixian Guo and Shuo Chen
    Citation: World Journal of Surgical Oncology 2022 20:234
  25. We aimed to explore whether body mass index (BMI) and albumin were associated with overall survival (OS) in individuals who underwent pancreaticoduodenectomy (PD) for cancer.

    Authors: Lei Cui, Huiping Yu, Qingmei Sun, Yi Miao, Kuirong Jiang and Xiaoping Fang
    Citation: World Journal of Surgical Oncology 2022 20:221
  26. The standard treatment for locally advanced rectal cancer (LARC) is preoperative chemoradiotherapy (CRT) followed by surgery and adjuvant chemotherapy. However, it has been suggested that intensification of ne...

    Authors: Ryota Mori, Mamoru Uemura, Yuki Sekido, Tsuyoshi Hata, Takayuki Ogino, Hidekazu Takahashi, Norikatsu Miyoshi, Tsunekazu Mizushima, Yuichiro Doki and Hidetoshi Eguchi
    Citation: World Journal of Surgical Oncology 2022 20:166
  27. Preliminary study results demonstrated parenchyma-sparing surgery (PSS) as an effective approach which allowed to remove colorectal cancer (CRC) metastatic lesions within the central liver cites and increased ...

    Authors: A. A. Burlaka, D. E. Makhmudov, I. I. Lisnyi, A. V. Paliichuk, V. V. Zvirych and A. V. Lukashenko
    Citation: World Journal of Surgical Oncology 2022 20:122
  28. Colon adenocarcinoma (COAD) is one of the most common malignant tumors and is diagnosed at an advanced stage with a poor prognosis worldwide. Pyroptosis is involved in the initiation and progression of tumors....

    Authors: Yuying Tan, Liqing Lu, Xujun Liang and Yongheng Chen
    Citation: World Journal of Surgical Oncology 2022 20:118
  29. Ferroptosis is associated with the development of many cancers; the molecular features of colorectal carcinoma (CRC) based on ferroptosis-related genes (FRGs) remain unknown. Herein, we aimed to identify ferro...

    Authors: Qingfang Yue, Yuan Zhang, Fei Wang, Fei Cao, Xianglong Duan and Jun Bai
    Citation: World Journal of Surgical Oncology 2022 20:117
  30. The ten-eleven translocation 1 (TET1), which is essential for active DNA demethylation, plays a multifaceted role in the pathogenesis of colorectal cancer. The study has demonstrated the association of TET1 mutat...

    Authors: Tianzhu Qiu, Xiaoxuan Wang, Furong Du, Xiangjing Hu, Fujun Sun, Chao Song and Jie Zhao
    Citation: World Journal of Surgical Oncology 2022 20:115
  31. We evaluated the influence of infectious complications, particularly surgical site infection (SSI), on long-term oncological results after elective laparoscopic resection of colorectal cancer.

    Authors: Nana Sugamata, Takashi Okuyama, Emiko Takeshita, Haruka Oi, Yuhei Hakozaki, Shunya Miyazaki, Musashi Takada, Takashi Mitsui, Takuji Noro, Hideyuki Yoshitomi and Masatoshi Oya
    Citation: World Journal of Surgical Oncology 2022 20:111
  32. To investigate the learning curve of conformal sphincter preservation operation (CSPO) in the treatment of ultralow rectal cancer and to further explore the influencing factors of operation time.

    Authors: Hai-bo Ding, Lin-hui Wang, Ge Sun, Guan-yu Yu, Xian-hua Gao, Kuo Zheng, Hai-feng Gong, Jin-ke Sui, Xiao-ming Zhu and Wei Zhang
    Citation: World Journal of Surgical Oncology 2022 20:102
  33. The aim of this study was to evaluate the efficacy of lateral pelvic lymph node (LPN) dissection (LPND) for rectal cancer patients with LPN metastasis (LPNM) and investigate the impact of LPNM on prognosis.

    Authors: Sicheng Zhou, Yujuan Jiang, Jianwei Liang and Qian Liu
    Citation: World Journal of Surgical Oncology 2022 20:97
  34. Colon adenocarcinoma (COAD) is one of the common cancers worldwide. Collagen triple helix repeat containing 1 (CTHRC1) has been reported to be involved in cell invasion, angiogenesis, and the promotion of epit...

    Authors: Chuang Meng, Yue Zhang, Dujun Jiang and Jian Wang
    Citation: World Journal of Surgical Oncology 2022 20:89
  35. To develop and evaluate the prognostic value of a comprehensive inflammatory biomarker for postoperative colorectal cancer (CRC) patients.

    Authors: Xiaoling Cai, Fa Chen, Lisheng Liang, Weizhong Jiang, Xing Liu, Dong Wang, Yunli Wu, Jinyan Chen, Guoxian Guan and Xian-e Peng
    Citation: World Journal of Surgical Oncology 2022 20:79
  36. The operative results of different approaches for the laparoscopic intersphincteric resection (LAISR) of low rectal cancer vary, and the patient characteristics associated with the best outcomes for each proce...

    Authors: Wenquan Ou, Xiaohua Wu, Jinfu Zhuang, Yuanfeng Yang, Yiyi Zhang, Xing Liu and Guoxian Guan
    Citation: World Journal of Surgical Oncology 2022 20:43
  37. The purpose of this study was to explore the risk factors for synchronous liver metastasis (LM) of colorectal cancer (CRC) and to construct a nomogram for predicting the occurrence of synchronous LM based on b...

    Authors: Yunxiao Liu, Yuliuming Wang, Hao Zhang, Mingyu Zheng, Chunlin Wang, Zhiqiao Hu, Yang Wang, Huan Xiong, Hanqing Hu, Qingchao Tang and Guiyu Wang
    Citation: World Journal of Surgical Oncology 2022 20:39
  38. The enhanced recovery after surgery (ERAS) program expedites patient recovery after major surgery. This study aimed to investigate the role of the triad of procalcitonin (PCT), C-reactive protein (CRP), and wh...

    Authors: Haidi Abd El Zaher, Waleed M. Ghareeb, Ahmed M. Fouad, Khaled Madbouly, Hamada Fathy, Tomas Vedin, Marcus Edelhamre, Sameh H. Emile and Mohammed Faisal
    Citation: World Journal of Surgical Oncology 2022 20:33

    The Correction to this article has been published in World Journal of Surgical Oncology 2022 20:64

  39. Early detection of colorectal cancer (CRC) improves prognosis, yet many CRCs are diagnosed following symptoms. The aim of this study was to determine which CRC-related symptoms or signs can predict an advanced...

    Authors: Rotem Gvirtzman, Dan Meir Livovsky, Esther Tahover, Eran Goldin and Benjamin Koslowsky
    Citation: World Journal of Surgical Oncology 2021 19:341
  40. The prognosis of obstructive colorectal cancer (oCRC) is worse than that of nonobstructive colorectal cancer. However, no previous study has established an individualized prediction model for the prognosis of ...

    Authors: Jian Lv, Yuan yuan Liu, Yi tao Jia, Jing li He, Guang yao Dai, Peng Guo, Zhao long Zhao, Yan ni Zhang and Zhong xin Li
    Citation: World Journal of Surgical Oncology 2021 19:337
  41. Capecitabine is a prodrug that is enzymatically converted to its active form, fluorouracil (also called 5-fluorouracil), which is commonly used as adjuvant chemotherapy in colorectal cancer patients. Severe ga...

    Authors: You Zou, Shuang Liu, Jianhong Wu and Zhen Sun
    Citation: World Journal of Surgical Oncology 2021 19:332
  42. Rectal cancer, one of most common neoplasms, is characterized by an overall survival rate exceeding 60%. Nonetheless, local recurrence (LR) following surgery for rectal cancer remains a formidable clinical pro...

    Authors: Michal Jankowski, Wojciech M. Wysocki, Manuela Las-Jankowska, Karol Tkaczyński, Dorian Wiśniewski, Dariusz Bała and Wojciech Zegarski
    Citation: World Journal of Surgical Oncology 2021 19:308
  43. Colorectal cancer (CRC) is one of the most common cancers of the gastrointestinal tract and ranks third in cancer-related deaths worldwide. This study was conducted to identify novel biomarkers related to the ...

    Authors: Xuan Yang, Wangao Wei, Shisheng Tan, Linrui Guo, Song Qiao, Biao Yao and Zi Wang
    Citation: World Journal of Surgical Oncology 2021 19:248
  44. Placement of a self-expanding metal stent (SEMS) in patients presenting with an acute colorectal obstruction (ACO) may obviate emergency surgery (ES), potentially effectively palliating incurable tumors, actin...

    Authors: Fei-hu Yan, Yao Zhang, Cheng-ling Bian, Xiao-shuang Liu, Bing-chen Chen, Zhen Wang, Hao Wang, E. Ji-fu and En-da Yu
    Citation: World Journal of Surgical Oncology 2021 19:194
  45. Understanding the vascular anatomy is critical for performing central vascular ligation (CVL) in right hemicolectomy with complete mesocolic excision (CME). This study aimed to investigate the predictive value...

    Authors: Hui Yu, Yong Zhuang, Jinliang Jian and Chunkang Yang
    Citation: World Journal of Surgical Oncology 2021 19:189
  46. Postoperative symptomatic anastomotic leakage (AL) is a serious complication after low anterior resection (LAR) for rectal cancer. AL can potentially affect short-term patient outcomes and long-term prognosis....

    Authors: Xinyu Qi, Maoxing Liu, Kai Xu, Pin Gao, Fei Tan, Zhendan Yao, Nan Zhang, Hong Yang, Chenghai Zhang, Jiadi Xing, Ming Cui and Xiangqian Su
    Citation: World Journal of Surgical Oncology 2021 19:187
  47. Lymph node metastasis (LNM) is a risk factor for poor long-term outcomes and a prognostic factor for disease-free survival in colon cancer. Preoperative lymph node status evaluation remains a challenge. The pu...

    Authors: Anna Mou, Hang Li, Xiao-li Chen, Yang-hua Fan and Hong Pu
    Citation: World Journal of Surgical Oncology 2021 19:179