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Current Evidence and Future Directions in the Treatment of Colorectal Cancer

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  1. Early detection of colorectal cancer (CRC) improves prognosis, yet many CRCs are diagnosed following symptoms. The aim of this study was to determine which CRC-related symptoms or signs can predict an advanced...

    Authors: Rotem Gvirtzman, Dan Meir Livovsky, Esther Tahover, Eran Goldin and Benjamin Koslowsky

    Citation: World Journal of Surgical Oncology 2021 19:341

    Content type: Research

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  2. The prognosis of obstructive colorectal cancer (oCRC) is worse than that of nonobstructive colorectal cancer. However, no previous study has established an individualized prediction model for the prognosis of ...

    Authors: Jian Lv, Yuan yuan Liu, Yi tao Jia, Jing li He, Guang yao Dai, Peng Guo, Zhao long Zhao, Yan ni Zhang and Zhong xin Li

    Citation: World Journal of Surgical Oncology 2021 19:337

    Content type: Research

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  3. Capecitabine is a prodrug that is enzymatically converted to its active form, fluorouracil (also called 5-fluorouracil), which is commonly used as adjuvant chemotherapy in colorectal cancer patients. Severe ga...

    Authors: You Zou, Shuang Liu, Jianhong Wu and Zhen Sun

    Citation: World Journal of Surgical Oncology 2021 19:332

    Content type: Case report

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  4. Rectal cancer, one of most common neoplasms, is characterized by an overall survival rate exceeding 60%. Nonetheless, local recurrence (LR) following surgery for rectal cancer remains a formidable clinical pro...

    Authors: Michal Jankowski, Wojciech M. Wysocki, Manuela Las-Jankowska, Karol Tkaczyński, Dorian Wiśniewski, Dariusz Bała and Wojciech Zegarski

    Citation: World Journal of Surgical Oncology 2021 19:308

    Content type: Research

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  5. Colorectal cancer (CRC) is one of the most common cancers of the gastrointestinal tract and ranks third in cancer-related deaths worldwide. This study was conducted to identify novel biomarkers related to the ...

    Authors: Xuan Yang, Wangao Wei, Shisheng Tan, Linrui Guo, Song Qiao, Biao Yao and Zi Wang

    Citation: World Journal of Surgical Oncology 2021 19:248

    Content type: Research

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  6. Placement of a self-expanding metal stent (SEMS) in patients presenting with an acute colorectal obstruction (ACO) may obviate emergency surgery (ES), potentially effectively palliating incurable tumors, actin...

    Authors: Fei-hu Yan, Yao Zhang, Cheng-ling Bian, Xiao-shuang Liu, Bing-chen Chen, Zhen Wang, Hao Wang, E. Ji-fu and En-da Yu

    Citation: World Journal of Surgical Oncology 2021 19:194

    Content type: Research

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  7. Understanding the vascular anatomy is critical for performing central vascular ligation (CVL) in right hemicolectomy with complete mesocolic excision (CME). This study aimed to investigate the predictive value...

    Authors: Hui Yu, Yong Zhuang, Jinliang Jian and Chunkang Yang

    Citation: World Journal of Surgical Oncology 2021 19:189

    Content type: Research

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  8. Postoperative symptomatic anastomotic leakage (AL) is a serious complication after low anterior resection (LAR) for rectal cancer. AL can potentially affect short-term patient outcomes and long-term prognosis....

    Authors: Xinyu Qi, Maoxing Liu, Kai Xu, Pin Gao, Fei Tan, Zhendan Yao, Nan Zhang, Hong Yang, Chenghai Zhang, Jiadi Xing, Ming Cui and Xiangqian Su

    Citation: World Journal of Surgical Oncology 2021 19:187

    Content type: Research

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  9. Lymph node metastasis (LNM) is a risk factor for poor long-term outcomes and a prognostic factor for disease-free survival in colon cancer. Preoperative lymph node status evaluation remains a challenge. The pu...

    Authors: Anna Mou, Hang Li, Xiao-li Chen, Yang-hua Fan and Hong Pu

    Citation: World Journal of Surgical Oncology 2021 19:179

    Content type: Research

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  10. Mistletoe extract, used as a complementary chemotherapeutic agent for cancer patients, has anticancer effects against various malignancies. The aim of the present study was to evaluate the effect of mistletoe ...

    Authors: Jeong-Heum Baek, Youngbae Jeon, Kyoung-Won Han, Dong Hae Jung and Kyung-Ok Kim

    Citation: World Journal of Surgical Oncology 2021 19:178

    Content type: Research

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  11. Robot-assisted surgery is increasingly implemented for the resection of colorectal cancer, although the scientific evidence for adopting this technique is still limited. This study’s main objective was to comp...

    Authors: Pedja Cuk, Randi Maria Simonsen, Mirjana Komljen, Michael Festersen Nielsen, Per Helligsø, Andreas Kristian Pedersen, Christian Backer Mogensen and Mark Bremholm Ellebæk

    Citation: World Journal of Surgical Oncology 2021 19:155

    Content type: Research

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  12. The main negative prognostic factors in patients with rectal cancer after radical treatment include regional lymph node involvement, lymphovascular invasion, and perineural invasion. However, some patients sti...

    Authors: Marcin Zeman, Marek Czarnecki, Ewa Chmielik, Adam Idasiak, Władysław Skałba, Mirosław Strączyński, Piotr J. Paul and Agnieszka Czarniecka

    Citation: World Journal of Surgical Oncology 2021 19:154

    Content type: Research

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  13. The inflammatory biomarker “C-reactive protein to albumin ratio (CAR)” has been reported to significantly correlate to a variety of human cancers. However, there are conflicting results regarding the prognosti...

    Authors: Chun-Kai Liao, Yen-Lin Yu, Yueh-Chen Lin, Yu-Jen Hsu, Yih-Jong Chern, Jy-Ming Chiang and Jeng-Fu You

    Citation: World Journal of Surgical Oncology 2021 19:139

    Content type: Review

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  14. Radiotherapy is a main therapeutic method for cancers, including colon cancer. In the current study, we aim to explore the effects of circular RNA (circRNA) circ_0055625 in the progression and radiosensitivity...

    Authors: Chao Gao, Yi Zhang, Yanming Tian, Chun Han, Lan Wang, Boyue Ding, Hua Tian, Chaoxi Zhou, Yingchao Ju, Ale Peng and Qiyao Yu

    Citation: World Journal of Surgical Oncology 2021 19:131

    Content type: Research

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  15. Most previous studies compared survival between left-sided and right-sided colon cancer without adjustment for clinicopathological parameters. We investigated the effect of sidedness on survival among patients...

    Authors: Zhuang-Sheng Huang, Jun-Wei Wu, Ying Li, Yu-Hai Lin and Xu-Yuan Li

    Citation: World Journal of Surgical Oncology 2021 19:127

    Content type: Research

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  16. Lymphovascular invasion (LVI) is defined as the presence of cancer cells in lymphatics or blood vessels. This study aimed to evaluate the prognostic value of LVI in stage II colorectal cancer (CRC) patients wi...

    Authors: Zhenyan Gao, Huihua Cao, Xiang Xu, Qing Wang, Yugang Wu and Qicheng Lu

    Citation: World Journal of Surgical Oncology 2021 19:125

    Content type: Research

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  17. The Chinese Society of Clinical Oncology guidelines 2018 and the recent update of that (version 2020) recommends accurate examination before major treatment for decision(s) in cases of colon cancer. Also, the ...

    Authors: Yadong Zhou, Zhiwei Han, Fafu Dou and Tao Yan

    Citation: World Journal of Surgical Oncology 2021 19:120

    Content type: Research

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  19. Radical resection is associated with good prognosis among patients with cT1/T2Nx rectal cancer. However, still some of the patients experienced cancer recurrence following radical resection. This study tried t...

    Authors: I-Li Lai, Jeng-Fu You, Yih-Jong Chern, Wen-Sy Tsai, Jy-Ming Chiang, Pao-Shiu Hsieh, Hsin-Yuan Hung and Yu-Jen Hsu

    Citation: World Journal of Surgical Oncology 2021 19:116

    Content type: Research

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  21. Colon cancer is a commonly worldwide cancer with high morbidity and mortality. Long non-coding RNAs (lncRNAs) are involved in many biological processes and are closely related to the occurrence of colon cancer...

    Authors: Meihong Gao, Yang Guo, Yifu Xiao and Xuequn Shang

    Citation: World Journal of Surgical Oncology 2021 19:104

    Content type: Research

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  22. Hepatectomy for resectable colorectal liver metastasis (CRLM) is recommended. However, the efficacy of upfront hepatectomy without neoadjuvant chemotherapy (NAC) is unclear due to the uncertainty of perioperat...

    Authors: Kosuke Ono, Tomoyuki Abe, Akihiko Oshita, Yusuke Sumi, Takuya Yano, Hiroshi Okuda, Manabu Kurayoshi, Tsuyoshi Kobayashi, Hideki Ohdan, Toshio Noriyuki and Masahiro Nakahara

    Citation: World Journal of Surgical Oncology 2021 19:97

    Content type: Research

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  23. Colorectal cancer is the third most common type of cancer in the world. We characterize a cohort of patients who survived up to 5 years without recurrence and identify factors predicting the probability of cure.

    Authors: Inge van den Berg, Robert R. J. Coebergh van den Braak, Jeroen L. A. van Vugt, Jan N. M. Ijzermans and Stefan Buettner

    Citation: World Journal of Surgical Oncology 2021 19:96

    Content type: Research

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    The Correction to this article has been published in World Journal of Surgical Oncology 2021 19:159

  24. Lymph node metastasis is a major prognostic sign of colorectal carcinoma and an important indicator for individualized treatment. M2 macrophages play a key role in carcinogenesis and tumor development by enhan...

    Authors: Yanping Wang, Jikun Wang, Chunyu Yang, Yue Wang, Jinhao Liu, Zuoxiu Shi, Yanlei Chen, Yang Feng, Xueqian Ma and Shifeng Qiao

    Citation: World Journal of Surgical Oncology 2021 19:91

    Content type: Research

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  27. This study aimed to investigate the short-term and oncological impact of the Endoscopic Surgical Skill Qualification System (ESSQS) by the Japan Society for Endoscopic Surgery on the operator performing laparo...

    Authors: Keisuke Kazama, Masakatsu Numata, Toru Aoyama, Yosuke Atsumi, Hiroshi Tamagawa, Teni Godai, Hiroyuki Saeki, Yusuke Saigusa, Manabu Shiozawa, Norio Yukawa, Munetaka Masuda and Yasushi Rino

    Citation: World Journal of Surgical Oncology 2021 19:53

    Content type: Research

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  28. Circular RNAs (circRNAs) are a class of endogenous single-strand RNA transcripts with crucial regulation in human cancers. The objective of this study is to investigate the role of circ_0082182 in CRC and its ...

    Authors: Ruijie Liu, Ping Deng, Yonglian Zhang, Yonglan Wang and Cuiping Peng

    Citation: World Journal of Surgical Oncology 2021 19:51

    Content type: Research

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  29. Histopathology is a crucial part of diagnosis and treatment guidance of colorectal cancer. In Denmark, it is not routine to biopsy during self-expandable metallic stent (SEMS) placement as a treatment option f...

    Authors: Sigrid Skov Bennedsgaard and Lene Hjerrild Iversen

    Citation: World Journal of Surgical Oncology 2021 19:48

    Content type: Review

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  30. Robotic and laparoscopic surgery for rectal cancer has been applied in the clinic for decades; nevertheless, which surgical approach has a lower rate of postoperative complications is still inconclusive. There...

    Authors: Bo Tang, Xiong Lei, Junhua Ai, Zhixiang Huang, Jun Shi and Taiyuan Li

    Citation: World Journal of Surgical Oncology 2021 19:38

    Content type: Research

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  31. The clinical significance of the geriatric nutritional risk index (GNRI) in locally advanced rectal cancer (LARC) patients undergoing preoperative chemoradiotherapy (CRT) followed by curative surgery has not b...

    Authors: Shozo Ide, Yoshinaga Okugawa, Yusuke Omura, Akira Yamamoto, Takashi Ichikawa, Takahito Kitajima, Tadanobu Shimura, Hiroki Imaoka, Hiroyuki Fujikawa, Hiromi Yasuda, Takeshi Yokoe, Yoshiki Okita, Masaki Ohi and Yuji Toiyama

    Citation: World Journal of Surgical Oncology 2021 19:34

    Content type: Research

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  32. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) improves survival in selected patients with peritoneal metastasis (PM) from colorectal cancer (CRC). However, little ...

    Authors: Yasuyuki Kamada, Koya Hida, Haruaki Ishibashi, Shouzou Sako, Akiyoshi Mizumoto, Masumi Ichinose, Naveen Padmanabhan, Shinya Yoshida and Yutaka Yonemura

    Citation: World Journal of Surgical Oncology 2021 19:31

    Content type: Research

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  33. Colorectal cancer patients undergoing surgical resection are at increased short-term risk of post-operative adverse events. However, specific predictors for long-term major adverse cardiac and cerebrovascular ...

    Authors: Chieh Yang Koo, Bee-Choo Tai, Dedrick Kok Hong Chan, Li Ling Tan, Ker Kan Tan and Chi-Hang Lee

    Citation: World Journal of Surgical Oncology 2021 19:21

    Content type: Research

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  34. Colorectal anastomosis using the double stapling technique (DST) has become a standard procedure. However, DST is difficult to perform in patients with anal stenosis because a circular stapler cannot be insert...

    Authors: Yosuke Tajima, Tsunekazu Hanai, Hidetoshi Katsuno, Koji Masumori, Yoshikazu Koide, Keigo Ashida, Hiroshi Matsuoka, Junichiro Hiro, Tomoyoshi Endo, Tadahiro Kamiya, Yongchol Chong, Kotaro Maeda and Ichiro Uyama

    Citation: World Journal of Surgical Oncology 2021 19:14

    Content type: Case report

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  35. Colon cancer is a worldwide leading cause of cancer-related mortality, and the prognosis of colon cancer is still needed to be improved. This study aimed to construct a prognostic model for predicting the prog...

    Authors: Zhengyu Fang, Sumei Xu, Yiwen Xie and Wenxi Yan

    Citation: World Journal of Surgical Oncology 2021 19:13

    Content type: Research

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  37. Though better short-term outcomes were frequently reported, differences in specimen parameters and the rate of subsequent peritoneal recurrence between intracorporeal anastomosis (IA) and extracorporeal anasto...

    Authors: Chun-Kai Liao, Yih-Jong Chern, Yueh-Chen Lin, Yu-Jen Hsu, Jy-Ming Chiang, Wen-Sy Tsai, Pao-Shiu Hsieh, Hsin-Yuan Hung, Chien-Yuh Yeh and Jeng-Fu You

    Citation: World Journal of Surgical Oncology 2021 19:6

    Content type: Research

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  38. Heterotopic ossification (HO) is the formation of osseous tissue outside the skeleton. HO in malignant tumors of the digestive tract is extremely rare, as is ossification in metastatic lesions from HO-negative...

    Authors: Hideki Nagano, Tamotsu Togawa, Takeshi Watanabe, Kenji Ohnishi, Toshihisa Kimura, Atsushi Iida, Sakon Noriki, Yoshiaki Imamura, Yasunori Sato and Takanori Goi

    Citation: World Journal of Surgical Oncology 2021 19:2

    Content type: Case report

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  39. Minimally invasive liver surgery (MILS) in the treatment of colorectal liver metastases (CRLM) is increasing in incidence. The aim of this work was to present our experience by reporting short-term and long-te...

    Authors: Mirhasan Rahimli, Aristotelis Perrakis, Vera Schellerer, Andrew Gumbs, Eric Lorenz, Mareike Franz, Jörg Arend, Victor-Radu Negrini and Roland Siegfried Croner

    Citation: World Journal of Surgical Oncology 2020 18:333

    Content type: Research

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  40. The alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase (ALKBH2) gene is involved in DNA repair and is expressed in different types of malignancies. However, the role of ALKBH2 in colorectal carcinoma (C...

    Authors: Bingxin Ke, Kejun Ye and Shaobing Cheng

    Citation: World Journal of Surgical Oncology 2020 18:328

    Content type: Research

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  41. Colorectal cancer (CRC) is the most common tumor of the gastrointestinal tract. Anastomotic leak (AL) and prolonged postoperative ileus (PPOI) are two important complications of colorectal surgery. In this obs...

    Authors: Michele Ammendola, Michele Ruggiero, Carlo Talarico, Riccardo Memeo, Giorgio Ammerata, Antonella Capomolla, Rosalinda Filippo, Roberto Romano, Socrate Pallio, Giuseppe Navarra, Severino Montemurro and Giuseppe Currò

    Citation: World Journal of Surgical Oncology 2020 18:327

    Content type: Research

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  42. Esophageal cancer patients often feel depressed and are fearful of metastasis and death. The objective of this study was to clarify the characteristics of patients with psychological distress at all 5 time poi...

    Authors: Yu Ohkura, Junichi Shindoh, Kanako Ichikura, Harushi Udagawa, Masaki Ueno and Eisuke Matsushima

    Citation: World Journal of Surgical Oncology 2020 18:326

    Content type: Research

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  43. Fluoropyrimidines and platinum are still widely used for colorectal cancer (CRC) management. Several studies have reported that mutations of dihydropyrimidine dehydrogenase (DPYD) and glutathione S-transferase pi...

    Authors: Xunwei Deng, Jingyuan Hou, Qiaoting Deng and Zhixiong Zhong

    Citation: World Journal of Surgical Oncology 2020 18:321

    Content type: Research

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  44. The rate of pulmonary metastasectomy from colorectal cancer (CRC) has increased with recent advances in chemotherapy, diagnostic techniques, and surgical procedures. The purpose of this study was to investigat...

    Authors: Masahiro Fukada, Nobuhisa Matsuhashi, Takao Takahashi, Yoshihiro Tanaka, Naoki Okumura, Hirotaka Yamamoto, Koyo Shirahashi, Hisashi Iwata, Kiyoshi Doi and Kazuhiro Yoshida

    Citation: World Journal of Surgical Oncology 2020 18:314

    Content type: Research

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  45. Nonoperative management after neoadjuvant treatment in low rectal cancer enables organ preservation and avoids surgical morbidity. Our aim is to compare oncological outcomes in patients with clinical complete ...

    Authors: Mariana F. Coraglio, Martin A. Eleta, Mirta R. Kujaruk, Javier H. Oviedo, Enrique L. Roca, Guillermo A. Masciangioli, Guillermo Mendez and Ilma S. Iseas

    Citation: World Journal of Surgical Oncology 2020 18:313

    Content type: Research

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  46. The impact of lateral lymph node dissection (LLND) in locally advanced lower rectal cancer remains controversial. This study is to compare total mesorectal excision (TME) with or without LLND in lower rectal c...

    Authors: Xiang Gao, Cun Wang, Yongyang Yu, Dujanand Singh, Lie Yang and Zongguang Zhou

    Citation: World Journal of Surgical Oncology 2020 18:304

    Content type: Research

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  47. Laparoscopic surgery for T4 colon cancer may be safe in selected patients. We hypothesized that small tumor size might preoperatively predict a good laparoscopic surgery outcome. Herein, we compared the clinic...

    Authors: Sung Sil Park, Joon Sang Lee, Hyoung-Chul Park, Sung Chan Park, Dae Kyung Sohn, Jae Hwan Oh, Kyung Su Han, Dong-Won Lee, Dong-Eun Lee, Sung-Bum Kang, Kyu Joo Park and Seung-Yong Jeong

    Citation: World Journal of Surgical Oncology 2020 18:299

    Content type: Research

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  49. Colorectal cancer (CRC) poses a heavy threat to human health owing to its high incidence and mortality. Circular RNAs (circRNAs) were investigated to participate in the progression of CRC, whereas there was no...

    Authors: Yanhe Liu, Hui Li, Xiaoyi Ye, Anlong Ji, Xiangwei Fu, Haishan Wu and Xiangyong Zeng

    Citation: World Journal of Surgical Oncology 2020 18:255

    Content type: Research

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  50. It has been demonstrated that simultaneous resection of both primary colorectal lesion and metastatic hepatic lesion is a safe approach with low mortality and postoperative complication rates. However, there a...

    Authors: Long Pan, Chenhao Tong, Siyuan Fu, Jing Fang, Qiuxia Gu, Shufeng Wang, Zhiyu Jiang, Sarun Juengpanich and Xiujun Cai

    Citation: World Journal of Surgical Oncology 2020 18:251

    Content type: Research

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