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Testing the boundaries of the brain’s immune system

Guest Editors:
Laura McCulloch: University of Edinburgh, UK 
Andrew Greenhalgh: University of Manchester, UK

Submission Status: Open   |   Submission Deadline: 31 March 2024


Journal of Inflammation is calling for submissions to our collection on Testing the boundaries of the brain’s immune system. The central nervous system is immunologically unique with specialised immune cells residing within its tissue and across its borders. In recent years, our understanding of the interaction of the CNS-associated immune system and the CNS parenchyma has improved and various specialized regions, including the meninges and the glymphatics, play crucial roles in mediating neuroinflammation during disease and injury.  

Image: Defence at the brain’s borders: CD11b+ F4/80+ meningeal perivascular macrophages lining vessels showing their heterogeneity in expression of MHCII-blue; CD169-green; CD163-red (Hyperion imaging, Greenhalgh Lab, unpublished data)

About the collection

Journal of Inflammation is calling for submissions to our collection on Testing the boundaries of the brain’s immune system. The central nervous system is immunologically unique with specialized immune cells residing within its tissue and across its borders. In recent years, our understanding of the interaction of the CNS-associated immune system and the CNS parenchyma has improved and various specialized regions, including the meninges and the glymphatics, play crucial roles in mediating neuroinflammation during disease and injury. To add additional complexity, CNS-associated immune cells can originate from multiple locations, such as the gut and the skull bone marrow. In this collection of articles, we will incorporate these relatively new concepts and provide an updated understanding of the role of neuroinflammation in various clinically relevant scenarios from infection, to sterile tissue injury and chronic neurodegeneration.

  1. The heme oxygenase-1 (HO-1) enzyme pathway is of crucial importance in the removal of toxic blood components and regulation of neuroinflammation following hemorrhagic stroke. Although a circadian pattern depen...

    Authors: Luise Henrich, Iva Kiessling, Matti Steimer, Sibylle Frase, Sandra Kaiser and Nils Schallner
    Citation: Journal of Inflammation 2023 20:43

Submission Guidelines

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This Collection welcomes submission of Research Articles, Data Notes, Case Reports, Study Protocols, and Database Articles. Before submitting your manuscript, please ensure you have read our submission guidelines. Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select "Testing the boundaries of the brain’s immune system" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests.