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Systems Biology and Medicine

Edited by Stephan Feller and Fred Schaper

In systems biology and medicine a huge divide seems to exist at present between what ‘cloud castle architects’ anticipate and what their hard-working fellow experimental scientists can actually accomplish. The review articles in this collection published in Cell Communication and Signaling reflect on some of the current methodologies and results, providing a snapshot of selected aspects, with an emphasis on what can be done at present and what must still be accomplished to fulfill some of those very enthusiastic projections in the coming decade(s).

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editors declare no competing interests.

View all collections published in Cell Communication and Signaling

  1. Review

    Recent development and biomedical applications of probabilistic Boolean networks

    Probabilistic Boolean network (PBN) modelling is a semi-quantitative approach widely used for the study of the topology and dynamic aspects of biological systems. The combined use of rule-based representation ...

    Panuwat Trairatphisan, Andrzej Mizera, Jun Pang, Alexandru Adrian Tantar, Jochen Schneider and Thomas Sauter

    Cell Communication and Signaling 2013 11:46

    Published on: 1 July 2013

  2. Review

    Mathematical modeling of apoptosis

    Apoptosis is a form of programmed cell death, which is fundamental to all multicellular organisms. Deregulation of apoptosis leads to a number of severe diseases including cancer. Apoptosis is initiated either...

    Kolja Schleich and Inna N Lavrik

    Cell Communication and Signaling 2013 11:44

    Published on: 26 June 2013

  3. Review

    Hypoxia-inducible factor (HIF) network: insights from mathematical models

    Oxygen is a crucial molecule for cellular function. When oxygen demand exceeds supply, the oxygen sensing pathway centred on the hypoxia inducible factor (HIF) is switched on and promotes adaptation to hypoxia...

    Miguel AS Cavadas, Lan K Nguyen and Alex Cheong

    Cell Communication and Signaling 2013 11:42

    Published on: 10 June 2013

  4. Review

    Complexity of dopamine metabolism

    Parkinson’s disease (PD) coincides with a dramatic loss of dopaminergic neurons within the substantia nigra. A key player in the loss of dopaminergic neurons is oxidative stress. Dopamine (DA) metabolism itself i...

    Johannes Meiser, Daniel Weindl and Karsten Hiller

    Cell Communication and Signaling 2013 11:34

    Published on: 17 May 2013

  5. Review

    Light microscopy applications in systems biology: opportunities and challenges

    Biological systems present multiple scales of complexity, ranging from molecules to entire populations. Light microscopy is one of the least invasive techniques used to access information from various biologic...

    Paul Paul Michel Aloyse Antony, Christophe Trefois, Aleksandar Stojanovic, Aidos Sagatovich Baumuratov and Karol Kozak

    Cell Communication and Signaling 2013 11:24

    Published on: 11 April 2013