Skip to main content


Short linear motifs - the unexplored frontier of the eukaryotic proteome

Edited by Norman Davey

Short linear motifs (SLiMs) guide the life of proteins from translation to destruction, directing their interactions, modification state, localisation and stability. The human proteome has been estimated to contain more than a hundred thousand – possibly up to a million – SLiM instances. Yet, to date, only a small fraction of the complete motif repertoire has been characterised and we still know relatively little about these elegantly simple protein interaction modules. This review series in Cell Communication and Signaling explores several central concepts that have emerged in the field of protein motif biology and, in doing so, highlights key questions about SLiMs that still remain to be answered.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer review process. The Guest Editor declares no competing interests.

View all collections published in Cell Communication and Signaling

  1. Review

    The new (dis)order in RNA regulation

    RNA-binding proteins play a key role in the regulation of all aspects of RNA metabolism, from the synthesis of RNA to its decay. Protein-RNA interactions have been thought to be mostly mediated by canonical RN...

    Aino I. Järvelin, Marko Noerenberg, Ilan Davis and Alfredo Castello

    Cell Communication and Signaling 2016 14:9

    Published on: 6 April 2016

  2. Review

    Phase separation in biology; functional organization of a higher order

    Inside eukaryotic cells, macromolecules are partitioned into membrane-bounded compartments and, within these, some are further organized into non-membrane-bounded structures termed membrane-less organelles. Th...

    Diana M. Mitrea and Richard W. Kriwacki

    Cell Communication and Signaling 2016 14:1

    Published on: 5 January 2016

  3. Review

    Short linear motifs – ex nihilo evolution of protein regulation

    Short sequence motifs are ubiquitous across the three major types of biomolecules: hundreds of classes and thousands of instances of DNA regulatory elements, RNA motifs and protein short linear motifs (SLiMs) ...

    Norman E. Davey, Martha S. Cyert and Alan M. Moses

    Cell Communication and Signaling 2015 13:43

    Published on: 21 November 2015