Skip to content

Advertisement

You're viewing the new version of our site. Please leave us feedback.

Learn more

Short linear motifs - the unexplored frontier of the eukaryotic proteome

Edited by Norman Davey

Short linear motifs (SLiMs) guide the life of proteins from translation to destruction, directing their interactions, modification state, localisation and stability. The human proteome has been estimated to contain more than a hundred thousand – possibly up to a million – SLiM instances. Yet, to date, only a small fraction of the complete motif repertoire has been characterised and we still know relatively little about these elegantly simple protein interaction modules. This review series in Cell Communication and Signaling explores several central concepts that have emerged in the field of protein motif biology and, in doing so, highlights key questions about SLiMs that still remain to be answered.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer review process. The Guest Editor declares no competing interests.

View all collections published in Cell Communication and Signaling

  1. Content type: Review

    RNA-binding proteins play a key role in the regulation of all aspects of RNA metabolism, from the synthesis of RNA to its decay. Protein-RNA interactions have been thought to be mostly mediated by canonical RN...

    Authors: Aino I. Järvelin, Marko Noerenberg, Ilan Davis and Alfredo Castello

    Citation: Cell Communication and Signaling 2016 14:9

    Published on:

  2. Content type: Review

    A substantial portion of the regulatory interactions in the higher eukaryotic cell are mediated by simple sequence motifs in the regulatory segments of genes and (pre-)mRNAs, and in the intrinsically disordere...

    Authors: Kim Van Roey and Norman E. Davey

    Citation: Cell Communication and Signaling 2015 13:45

    Published on:

  3. Content type: Review

    Short sequence motifs are ubiquitous across the three major types of biomolecules: hundreds of classes and thousands of instances of DNA regulatory elements, RNA motifs and protein short linear motifs (SLiMs) ...

    Authors: Norman E. Davey, Martha S. Cyert and Alan M. Moses

    Citation: Cell Communication and Signaling 2015 13:43

    Published on:

  4. Content type: Review

    It has become clear in outline though not yet in detail how cellular regulatory and signalling systems are constructed. The essential machines are protein complexes that effect regulatory decisions by undergoi...

    Authors: Toby J. Gibson, Holger Dinkel, Kim Van Roey and Francesca Diella

    Citation: Cell Communication and Signaling 2015 13:42

    Published on:

Advertisement