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Schistosomiasis research: providing the tools needed for elimination

Guest edited by David Rollinson, Jutta Reinhard-Rupp, Robert Bergquist and Xiao-Nong Zhou

An article collection in Infectious Diseases of Poverty

Considerable progress is being made in many endemic countries to reduce morbidity and prevalence of both urinary and intestinal schistosomiasis. National schistosomiasis control programmes in Africa have for the most part depended on donated drugs and external financial support for implementation. Delegates to the Sixty-fifth World Health Assembly, who adopted resolution WHA65.21 on the elimination of schistosomiasis, called for greater action. They encouraged Member States to take advantage of other on-going activities to intensify schistosomiasis control programmes and to initiate elimination campaigns where appropriate, through strengthened health systems, preventive chemotherapy, provision of water and sanitation, as well as hygiene education and snail control.

Hence it was timely that on 14 June 2016, leading experts in the control and elimination of schistosomiasis from around the world gathered in Shanghai to advance the WHO’s goal of worldwide elimination of the disease along with a number of other neglected tropical diseases. Organized by the Global Schistosomiasis Alliance (GSA), the two-day meeting brought together health specialists, research scientists and control programme managers to review current progress and to discuss such topics as new drugs, mapping the transmission of the disease and alternative control strategies. This special issue draws together some of the ideas presented at the meeting and helps focus attention on the research gaps that need to be filled in order to achieve elimination targets.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editors declare no competing interests.

  1. Content type: Scoping Review

    Historically, the target in the schistosomiasis control has shifted from infection to morbidity, then back to infection, but now as a public health problem, before moving on to transmission control. Currently,...

    Authors: Robert Bergquist, Xiao-Nong Zhou, David Rollinson, Jutta Reinhard-Rupp and Katharina Klohe

    Citation: Infectious Diseases of Poverty 2017 6:158

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  2. Content type: Research Article

    Given the restricted distribution of Schistosoma mekongi in one province in Lao People’s Democratic Republic (Lao PDR) and two provinces in Cambodia, together with progress of the national control programmes aime...

    Authors: Youthanavanh Vonghachack, Somphou Sayasone, Virak Khieu, Robert Bergquist, Govert J. van Dam, Pytsje T. Hoekstra, Paul L. A. M. Corstjens, Beatrice Nickel, Hanspeter Marti, Jürg Utzinger, Sinuon Muth and Peter Odermatt

    Citation: Infectious Diseases of Poverty 2017 6:127

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  3. Content type: Commentary

    Schistosomiasis is a parasitic disease caused by blood flukes. The disease is caused by an inflammatory reaction to parasite eggs retained in the liver, bladder and reproductive organs. According to 2017 World...

    Authors: Jutta Reinhard-Rupp and Katharina Klohe

    Citation: Infectious Diseases of Poverty 2017 6:122

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  4. Content type: Research Article

    Mass drug administration of praziquantel is the World Health Organization’s endorsed control strategy for schistosomiasis. A decade of annual treatments across sub-Saharan Africa has resulted in significant re...

    Authors: Poppy H.L. Lamberton, Christina L. Faust and Joanne P. Webster

    Citation: Infectious Diseases of Poverty 2017 6:110

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  5. Content type: Research Article

    The prevalence of schistosomiasis remains a key public health issue in China. Jiangling County in Hubei Province is a typical lake and marshland endemic area. The pattern analysis of schistosomiasis prevalence...

    Authors: Shang Xia, Jing-Bo Xue, Xia Zhang, He-Hua Hu, Eniola Michael Abe, David Rollinson, Robert Bergquist, Yibiao Zhou, Shi-Zhu Li and Xiao-Nong Zhou

    Citation: Infectious Diseases of Poverty 2017 6:91

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  6. Content type: Research Article

    Schistosomiasis is a water-borne disease caused by trematode worms belonging to genus Schistosoma, which is prevalent most of the developing world. Transmission of the disease is usually associated with multiple ...

    Authors: Yi Hu, Congcong Xia, Shizhu Li, Michael P. Ward, Can Luo, Fenghua Gao, Qizhi Wang, Shiqing Zhang and Zhijie Zhang

    Citation: Infectious Diseases of Poverty 2017 6:87

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  7. Content type: Research Article

    Schistosomiasis japonica is a common zoonosis. Domestic animals are the primary source of infection and play an important role in disease transmission. The prevalence and infectivity of this disease in domesti...

    Authors: Xin Zhang, Chuan-Chuan He, Jin-Ming Liu, Hao Li, Ke Lu, Zhi-Qiang Fu, Chuan-Gang Zhu, Yi-Ping Liu, Lai-Bao Tong, De-bao Zhou, Li Zha, Yang Hong, Ya-Mei Jin and Jiao-Jiao Lin

    Citation: Infectious Diseases of Poverty 2017 6:86

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  8. Content type: Research Article

    Despite its low cure rates and possible resistance, praziquantel (PZQ) is the only drug available for schistosomiasis treatment. Hence, monitoring its efficacy is crucial. This study assessed the efficacy of P...

    Authors: Muhubiri Kabuyaya, Moses John Chimbari, Tawanda Manyangadze and Samson Mukaratirwa

    Citation: Infectious Diseases of Poverty 2017 6:83

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  9. Content type: Short report

    Schistosomiasis remains a major public health concern in China and an epidemiological survey has revealed that schistosome-infected bovines and goats are the main transmission sources for the disease. Therefor...

    Authors: Rui Xu, Jintao Feng, Yang Hong, Chao Lv, Dengyun Zhao, Jiaojiao Lin, Ke Lu, Hao Li, Jinming Liu, Xiaodan Cao, Tao Wang, Jinli Zai, Zhaozhe Wang, Bingguang Jia, Qian Han and Chuangang Zhu

    Citation: Infectious Diseases of Poverty 2017 6:84

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  10. Content type: Research Article

    Schistosomiasis remains a major public health concern in China. Since 2004, an integrated strategy was developed to control the transmission of Schistosoma japonicum in China. However, the long-term effectiveness...

    Authors: Yang Liu, Bo Zhong, Zi-Song Wu, Song Liang, Dong-Chuan Qiu and Xiao Ma

    Citation: Infectious Diseases of Poverty 2017 6:79

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  11. Content type: Scoping Review

    Despite increased international efforts to control schistosomiasis using preventive chemotherapy, several challenges still exist in reaching the target populations. Until recently, preschool-aged children had ...

    Authors: Takafira Mduluza and Francisca Mutapi

    Citation: Infectious Diseases of Poverty 2017 6:85

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  12. Content type: Research Article

    After alleged stop of transmission of schistosomiasis and further down the line in post elimination settings, sensitive tools are required to monitor infection status to prevent potential re-emergence. In Raha...

    Authors: Abdelaali Balahbib, Fatima Amarir, Paul L.A.M. Corstjens, Claudia J. de Dood, Govert J. van Dam, Amina Hajli, Meryem Belhaddad, Bouchra El Mansouri, Abderrahim Sadak, Mohamed Rhajaoui and El Bachir Adlaoui

    Citation: Infectious Diseases of Poverty 2017 6:75

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  13. Content type: Scoping Review

    The current approach of morbidity control of schistosomiasis, a helminth disease of poverty with considerable public health and socioeconomic impact, is based on preventive chemotherapy with praziquantel. Ther...

    Authors: Robert Bergquist, Jürg Utzinger and Jennifer Keiser

    Citation: Infectious Diseases of Poverty 2017 6:74

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  14. Content type: Opinion

    Schistosomiasis, one of the 17 neglected tropical diseases listed by the World Health Organization, presents a substantial public health and economic burden. Of the 261 million people requiring preventive chem...

    Authors: Lorenzo Savioli, Marco Albonico, Daniel G. Colley, Rodrigo Correa-Oliveira, Alan Fenwick, Will Green, Narcis Kabatereine, Achille Kabore, Naftale Katz, Katharina Klohe, Philip T. LoVerde, David Rollinson, J. Russell Stothard, Louis-Albert Tchuem Tchuenté, Johannes Waltz and Xiao-Nong Zhou

    Citation: Infectious Diseases of Poverty 2017 6:65

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  15. Content type: Scoping Review

    Mapping and diagnosis of infections by the three major schistosome species (Schistosoma haematobium, S. mansoni and S. japonicum) has been done with assays that are known to be specific but increasingly insensiti...

    Authors: Daniel G. Colley, Tamara S. Andros and Carl H. Campbell Jr.

    Citation: Infectious Diseases of Poverty 2017 6:63

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  16. Content type: Research Article

    Schistosomiasis is a global snail-transmitted infectious disease of poverty. Transmission control had been achieved in China in 2015 after the control efforts for over 60 years. Currently, the remaining core r...

    Authors: Le-Ping Sun, Wei Wang, Yin-Ping Zuo, Zheng-Qiu Zhang, Qing-Biao Hong, Guo-Jing Yang, Hong-Ru Zhu, You-Sheng Liang and Hai-Tao Yang

    Citation: Infectious Diseases of Poverty 2017 6:72

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  17. Content type: Scoping Review

    Schistosomiasis japonica, caused by the human blood fluke Schistosoma japonicum, remains a major public health problem in China, although great success has been achieved. The control efforts during the past half-...

    Authors: Le-Ping Sun, Wei Wang, Qing-Biao Hong, Shi-Zhu Li, You-Sheng Liang, Hai-Tao Yang and Xiao-Nong Zhou

    Citation: Infectious Diseases of Poverty 2017 6:55

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  18. Content type: Research Article

    Although great success has been achieved, schistosomiasis remains a major public health concern in China, and the remaining core endemic regions are concentrated along the middle and lower reaches of the Yangt...

    Authors: Le-Ping Sun, Wei Wang, Yin-Ping Zuo, Qing-Biao Hong, Guang-Lin Du, Yu-Cai Ma, Jian Wang, Guo-Jing Yang, Dao-Jian Zhu and You-Sheng Liang

    Citation: Infectious Diseases of Poverty 2017 6:56

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  19. Content type: Research Article

    Urogenital schistosomiasis is a parasitic infection of public health importance that affects over 112 million people worldwide. The study aimed at assessing the urogenital schistosomiasis prevalence and risk f...

    Authors: Adeline P. Mewabo, Roger S. Moyou, Lysette E. Kouemeni, Jeanne Y. Ngogang, Lazare Kaptue and Ernest Tambo

    Citation: Infectious Diseases of Poverty 2017 6:40

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  20. Content type: Research Article

    The crater lakes of Barombi Mbo and Barombi Kotto are well-known transmission foci of schistosomiasis and soil-transmitted helminthiasis having had several important control initiatives previously. To collect ...

    Authors: Suzy J. Campbell, J. Russell Stothard, Faye O’Halloran, Deborah Sankey, Timothy Durant, Dieudonné Eloundou Ombede, Gwladys Djomkam Chuinteu, Bonnie L. Webster, Lucas Cunningham, E. James LaCourse and Louis-Albert Tchuem-Tchuenté

    Citation: Infectious Diseases of Poverty 2017 6:49

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  21. Content type: Research Article

    Urinary schistosomiasis has been a major public health problem in Zambia for many years. However, the disease profile may vary in different locale due to the changing ecosystem that contributes to the risk of ...

    Authors: Christopher Simoonga and Lawrence N. Kazembe

    Citation: Infectious Diseases of Poverty 2017 6:43

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  22. Content type: Scoping Review

    Schistosomiasis is a water borne parasitic disease of global importance and with ongoing control the disease endemic landscape is changing. In sub-Saharan Africa, for example, the landscape is becoming ever mo...

    Authors: Louis-Albert Tchuem Tchuenté, David Rollinson, J. Russell Stothard and David Molyneux

    Citation: Infectious Diseases of Poverty 2017 6:42

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  23. Content type: Research Article

    Intestinal schistosomiasis is of public health importance in Uganda but communities living above 1400 m are not targeted for control as natural transmission is thought unlikely. To assess altitudinal boundarie...

    Authors: Michelle C. Stanton, Moses Adriko, Moses Arinaitwe, Alison Howell, Juliet Davies, Gillian Allison, E. James LaCourse, Edridah Muheki, Narcis B. Kabatereine and J. Russell Stothard

    Citation: Infectious Diseases of Poverty 2017 6:34

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  24. Content type: Scoping Review

    Schistosomiasis is a waterborne parasitic disease in sub-Saharan Africa, particularly common in rural populations living in impoverished conditions. With the scale-up of preventive chemotherapy, national campa...

    Authors: J. Russell Stothard, Suzy J. Campbell, Mike Y. Osei-Atweneboana, Timothy Durant, Michelle C. Stanton, Nana-Kwadwo Biritwum, David Rollinson, Dieudonné R. Eloundou Ombede and Louis-Albert Tchuem-Tchuenté

    Citation: Infectious Diseases of Poverty 2017 6:10

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  25. Content type: Research Article

    Intestinal schistosomiasis due to Schistosoma mansoni was first reported in Oman in 1979. We describe the trend in parasitological and serological prevalence of human infection with S. mansoni in the endemic area...

    Authors: Idris Al Abaidani, Seif Al-Abri, Mahmoud Shaban, Satish L. Ghugey, Salem Al Kathery, Khalid Al-Mashikhi, Amadou Garba and Albis Francesco Gabrielli

    Citation: Infectious Diseases of Poverty 2016 5:112

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