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Schistosomiasis research: providing the tools needed for elimination

Guest edited by David Rollinson, Jutta Reinhard-Rupp, Robert Bergquist and Xiao-Nong Zhou

An article collection in Infectious Diseases of Poverty

Considerable progress is being made in many endemic countries to reduce morbidity and prevalence of both urinary and intestinal schistosomiasis. National schistosomiasis control programmes in Africa have for the most part depended on donated drugs and external financial support for implementation. Delegates to the Sixty-fifth World Health Assembly, who adopted resolution WHA65.21 on the elimination of schistosomiasis, called for greater action. They encouraged Member States to take advantage of other on-going activities to intensify schistosomiasis control programmes and to initiate elimination campaigns where appropriate, through strengthened health systems, preventive chemotherapy, provision of water and sanitation, as well as hygiene education and snail control.

Hence it was timely that on 14 June 2016, leading experts in the control and elimination of schistosomiasis from around the world gathered in Shanghai to advance the WHO’s goal of worldwide elimination of the disease along with a number of other neglected tropical diseases. Organized by the Global Schistosomiasis Alliance (GSA), the two-day meeting brought together health specialists, research scientists and control programme managers to review current progress and to discuss such topics as new drugs, mapping the transmission of the disease and alternative control strategies. This special issue draws together some of the ideas presented at the meeting and helps focus attention on the research gaps that need to be filled in order to achieve elimination targets.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editors declare no competing interests.

  1. Research Article

    Praziquantel decreases fecundity in Schistosoma mansoni adult worms that survive treatment: evidence from a laboratory life-history trade-offs selection study

    Mass drug administration of praziquantel is the World Health Organization’s endorsed control strategy for schistosomiasis. A decade of annual treatments across sub-Saharan Africa has resulted in significant re...

    Poppy H.L. Lamberton, Christina L. Faust and Joanne P. Webster

    Infectious Diseases of Poverty 2017 6:110

    Published on: 16 June 2017

  2. Research Article

    Pattern analysis of schistosomiasis prevalence by exploring predictive modeling in Jiangling County, Hubei Province, P.R. China

    The prevalence of schistosomiasis remains a key public health issue in China. Jiangling County in Hubei Province is a typical lake and marshland endemic area. The pattern analysis of schistosomiasis prevalence...

    Shang Xia, Jing-Bo Xue, Xia Zhang, He-Hua Hu, Eniola Michael Abe, David Rollinson, Robert Bergquist, Yibiao Zhou, Shi-Zhu Li and Xiao-Nong Zhou

    Infectious Diseases of Poverty 2017 6:91

    Published on: 26 April 2017

  3. Research Article

    Assessing environmental factors associated with regional schistosomiasis prevalence in Anhui Province, Peoples’ Republic of China using a geographical detector method

    Schistosomiasis is a water-borne disease caused by trematode worms belonging to genus Schistosoma, which is prevalent most of the developing world. Transmission of the disease is usually associated with multiple ...

    Yi Hu, Congcong Xia, Shizhu Li, Michael P. Ward, Can Luo, Fenghua Gao, Qizhi Wang, Shiqing Zhang and Zhijie Zhang

    Infectious Diseases of Poverty 2017 6:87

    Published on: 17 April 2017

  4. Research Article

    Nested-PCR assay for detection of Schistosoma japonicum infection in domestic animals

    Schistosomiasis japonica is a common zoonosis. Domestic animals are the primary source of infection and play an important role in disease transmission. The prevalence and infectivity of this disease in domesti...

    Xin Zhang, Chuan-Chuan He, Jin-Ming Liu, Hao Li, Ke Lu, Zhi-Qiang Fu, Chuan-Gang Zhu, Yi-Ping Liu, Lai-Bao Tong, De-bao Zhou, Li Zha, Yang Hong, Ya-Mei Jin and Jiao-Jiao Lin

    Infectious Diseases of Poverty 2017 6:86

    Published on: 13 April 2017

  5. Scoping Review

    Putting the treatment of paediatric schistosomiasis into context

    Despite increased international efforts to control schistosomiasis using preventive chemotherapy, several challenges still exist in reaching the target populations. Until recently, preschool-aged children had ...

    Takafira Mduluza and Francisca Mutapi

    Infectious Diseases of Poverty 2017 6:85

    Published on: 7 April 2017

  6. Research Article

    Interruption of schistosomiasis transmission in mountainous and hilly regions with an integrated strategy: a longitudinal case study in Sichuan, China

    Schistosomiasis remains a major public health concern in China. Since 2004, an integrated strategy was developed to control the transmission of Schistosoma japonicum in China. However, the long-term effectiveness...

    Yang Liu, Bo Zhong, Zi-Song Wu, Song Liang, Dong-Chuan Qiu and Xiao Ma

    Infectious Diseases of Poverty 2017 6:79

    Published on: 7 April 2017

  7. Short report

    A novel colloidal gold immunochromatography assay strip for the diagnosis of schistosomiasis japonica in domestic animals

    Schistosomiasis remains a major public health concern in China and an epidemiological survey has revealed that schistosome-infected bovines and goats are the main transmission sources for the disease. Therefor...

    Rui Xu, Jintao Feng, Yang Hong, Chao Lv, Dengyun Zhao, Jiaojiao Lin, Ke Lu, Hao Li, Jinming Liu, Xiaodan Cao, Tao Wang, Jinli Zai, Zhaozhe Wang, Bingguang Jia, Qian Han and Chuangang Zhu

    Infectious Diseases of Poverty 2017 6:84

    Published on: 7 April 2017

  8. Research Article

    Efficacy of praziquantel on Schistosoma haematobium and re-infection rates among school-going children in the Ndumo area of uMkhanyakude district, KwaZulu-Natal, South Africa

    Despite its low cure rates and possible resistance, praziquantel (PZQ) is the only drug available for schistosomiasis treatment. Hence, monitoring its efficacy is crucial. This study assessed the efficacy of P...

    Muhubiri Kabuyaya, Moses John Chimbari, Tawanda Manyangadze and Samson Mukaratirwa

    Infectious Diseases of Poverty 2017 6:83

    Published on: 7 April 2017

  9. Research Article

    Selecting accurate post-elimination monitoring tools to prevent reemergence of urogenital schistosomiasis in Morocco: a pilot study

    After alleged stop of transmission of schistosomiasis and further down the line in post elimination settings, sensitive tools are required to monitor infection status to prevent potential re-emergence. In Raha...

    Abdelaali Balahbib, Fatima Amarir, Paul L.A.M. Corstjens, Claudia J. de Dood, Govert J. van Dam, Amina Hajli, Meryem Belhaddad, Bouchra El Mansouri, Abderrahim Sadak, Mohamed Rhajaoui and El Bachir Adlaoui

    Infectious Diseases of Poverty 2017 6:75

    Published on: 6 April 2017

  10. Opinion

    Building a global schistosomiasis alliance: an opportunity to join forces to fight inequality and rural poverty

    Schistosomiasis, one of the 17 neglected tropical diseases listed by the World Health Organization, presents a substantial public health and economic burden. Of the 261 million people requiring preventive chem...

    Lorenzo Savioli, Marco Albonico, Daniel G. Colley, Rodrigo Correa-Oliveira, Alan Fenwick, Will Green, Narcis Kabatereine, Achille Kabore, Naftale Katz, Katharina Klohe, Philip T. LoVerde, David Rollinson, J. Russell Stothard, Louis-Albert Tchuem Tchuenté, Johannes Waltz and Xiao-Nong Zhou

    Infectious Diseases of Poverty 2017 6:65

    Published on: 23 March 2017

  11. Research Article

    An integrated environmental improvement of marshlands: impact on control and elimination of schistosomiasis in marshland regions along the Yangtze River, China

    Schistosomiasis is a global snail-transmitted infectious disease of poverty. Transmission control had been achieved in China in 2015 after the control efforts for over 60 years. Currently, the remaining core r...

    Le-Ping Sun, Wei Wang, Yin-Ping Zuo, Zheng-Qiu Zhang, Qing-Biao Hong, Guo-Jing Yang, Hong-Ru Zhu, You-Sheng Liang and Hai-Tao Yang

    Infectious Diseases of Poverty 2017 6:72

    Published on: 22 March 2017

  12. Scoping Review

    Schistosomiasis is more prevalent than previously thought: what does it mean for public health goals, policies, strategies, guidelines and intervention programs?

    Mapping and diagnosis of infections by the three major schistosome species (Schistosoma haematobium, S. mansoni and S. japonicum) has been done with assays that are known to be specific but increasingly insensiti...

    Daniel G. Colley, Tamara S. Andros and Carl H. Campbell

    Infectious Diseases of Poverty 2017 6:63

    Published on: 22 March 2017

  13. Scoping Review

    Approaches being used in the national schistosomiasis elimination programme in China: a review

    Schistosomiasis japonica, caused by the human blood fluke Schistosoma japonicum, remains a major public health problem in China, although great success has been achieved. The control efforts during the past half-...

    Le-Ping Sun, Wei Wang, Qing-Biao Hong, Shi-Zhu Li, You-Sheng Liang, Hai-Tao Yang and Xiao-Nong Zhou

    Infectious Diseases of Poverty 2017 6:55

    Published on: 15 March 2017

  14. Research Article

    A multidisciplinary, integrated approach for the elimination of schistosomiasis: a longitudinal study in a historically hyper-endemic region in the lower reaches of the Yangtze River, China from 2005 to 2014

    Although great success has been achieved, schistosomiasis remains a major public health concern in China, and the remaining core endemic regions are concentrated along the middle and lower reaches of the Yangt...

    Le-Ping Sun, Wei Wang, Yin-Ping Zuo, Qing-Biao Hong, Guang-Lin Du, Yu-Cai Ma, Jian Wang, Guo-Jing Yang, Dao-Jian Zhu and You-Sheng Liang

    Infectious Diseases of Poverty 2017 6:56

    Published on: 14 March 2017

  15. Research Article

    Assessing the prevalence of urogenital schistosomaisis and transmission risk factors amongst school-aged children around Mapé dam ecological suburbs in Malantouen district, Cameroon

    Urogenital schistosomiasis is a parasitic infection of public health importance that affects over 112 million people worldwide. The study aimed at assessing the urogenital schistosomiasis prevalence and risk f...

    Adeline P. Mewabo, Roger S. Moyou, Lysette E. Kouemeni, Jeanne Y. Ngogang, Lazare Kaptue and Ernest Tambo

    Infectious Diseases of Poverty 2017 6:40

    Published on: 6 March 2017

  16. Research Article

    Urogenital schistosomiasis and soil-transmitted helminthiasis (STH) in Cameroon: An epidemiological update at Barombi Mbo and Barombi Kotto crater lakes assessing prospects for intensified control interventions

    The crater lakes of Barombi Mbo and Barombi Kotto are well-known transmission foci of schistosomiasis and soil-transmitted helminthiasis having had several important control initiatives previously. To collect ...

    Suzy J. Campbell, J. Russell Stothard, Faye O’Halloran, Deborah Sankey, Timothy Durant, Dieudonné Eloundou Ombede, Gwladys Djomkam Chuinteu, Bonnie L. Webster, Lucas Cunningham, E. James LaCourse and Louis-Albert Tchuem-Tchuenté

    Infectious Diseases of Poverty 2017 6:49

    Published on: 27 February 2017

  17. Research Article

    Using the hierarchical ordinal regression model to analyse the intensity of urinary schistosomiasis infection in school children in Lusaka Province, Zambia

    Urinary schistosomiasis has been a major public health problem in Zambia for many years. However, the disease profile may vary in different locale due to the changing ecosystem that contributes to the risk of ...

    Christopher Simoonga and Lawrence N. Kazembe

    Infectious Diseases of Poverty 2017 6:43

    Published on: 21 February 2017

  18. Scoping Review

    Moving from control to elimination of schistosomiasis in sub-Saharan Africa: time to change and adapt strategies

    Schistosomiasis is a water borne parasitic disease of global importance and with ongoing control the disease endemic landscape is changing. In sub-Saharan Africa, for example, the landscape is becoming ever mo...

    Louis-Albert Tchuem Tchuenté, David Rollinson, J. Russell Stothard and David Molyneux

    Infectious Diseases of Poverty 2017 6:42

    Published on: 20 February 2017

  19. Research Article

    Intestinal schistosomiasis in Uganda at high altitude (>1400 m): malacological and epidemiological surveys on Mount Elgon and in Fort Portal crater lakes reveal extra preventive chemotherapy needs

    Intestinal schistosomiasis is of public health importance in Uganda but communities living above 1400 m are not targeted for control as natural transmission is thought unlikely. To assess altitudinal boundarie...

    Michelle C. Stanton, Moses Adriko, Moses Arinaitwe, Alison Howell, Juliet Davies, Gillian Allison, E. James LaCourse, Edridah Muheki, Narcis B. Kabatereine and J. Russell Stothard

    Infectious Diseases of Poverty 2017 6:34

    Published on: 6 February 2017

  20. Scoping Review

    Towards interruption of schistosomiasis transmission in sub-Saharan Africa: developing an appropriate environmental surveillance framework to guide and to support ‘end game’ interventions

    Schistosomiasis is a waterborne parasitic disease in sub-Saharan Africa, particularly common in rural populations living in impoverished conditions. With the scale-up of preventive chemotherapy, national campa...

    J. Russell Stothard, Suzy J. Campbell, Mike Y. Osei-Atweneboana, Timothy Durant, Michelle C. Stanton, Nana-Kwadwo Biritwum, David Rollinson, Dieudonné R. Eloundou Ombede and Louis-Albert Tchuem-Tchuenté

    Infectious Diseases of Poverty 2017 6:10

    Published on: 14 January 2017

  21. Research Article

    Decline in transmission of schistosomiasis mansoni in Oman

    Intestinal schistosomiasis due to Schistosoma mansoni was first reported in Oman in 1979. We describe the trend in parasitological and serological prevalence of human infection with S. mansoni in the endemic area...

    Idris Al Abaidani, Seif Al-Abri, Mahmoud Shaban, Satish L. Ghugey, Salem Al Kathery, Khalid Al-Mashikhi, Amadou Garba and Albis Francesco Gabrielli

    Infectious Diseases of Poverty 2016 5:112

    Published on: 12 December 2016

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