Genome Biology is calling for submissions to our Collection on intracellular compartments.
Compartmentalization plays an essential role in maintaining cellular processes and functions. The spatial segregation within cells leads to the formation of distinct biophysical environments within the cell, allowing the concentration of specific molecules and enabling various cellular processes, such as gene expression and signal transduction. These compartments include the recently discovered membraneless organelles formed by phase separation, which lack a traditional lipid bilayer and serve as dynamic hubs for a range of cellular activities.
This collection aims to gather original research and methodological articles that delve into the multifaceted aspects of subcellular organization. It welcomes computational and experimental studies exploring the mechanisms behind the formation and function of these compartments, their interactions with other cellular components, and their impact on overall cell physiology in the context of genome biology. Moreover, articles that synthesize complex biological data to offer a more comprehensive understanding of these processes are highly encouraged.
Such research is not only crucial for advancing our fundamental understanding of cell biology but also has potential implications in understanding diseases linked to dysfunctions in cellular compartmentalization. By exploring these novel aspects of cellular organization, the collection aims to contribute significantly to the broader field of cellular and molecular biology. Topics accepted for submission include, but are not limited to:
- Membraneless organelles by phase-separation
- Nuclear organization
- Genomic regulation within subcellular compartments
- Epigenetic modifications shaping the spatial organization of cells
- Cytoplasmic compartmentalization
- Emerging techniques for the study of subcellular compartmentalization
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