Stem Cell Research & Therapy is calling for submissions to our collection on Stromal cells and progenitor cells for osteoarticular regeneration. Mesenchymal stem cells (MSCs) is an attractive therapy since these cells exhibit chondrogenic and anti-inflammatory properties. Mesenchymal cells have regenerative capacity of cartilage, protective tissue hypoxia and suffering, prevention of fibrosis and reduction of local inflammatory process. MSCs are isolated from a large number of tissues, including bone marrow, and adipose tissues. They are able to differentiate into mesodermal lineages (osteoblasts, chondrocytes and adipocytes) and to exhibit immunosuppressive as well as healing capacities, through the secretion of paracrine mediators but also change surrounding cells metabolism through mitochondrial transfer. Several clinical trials in OA have shown modest improvement in pain and function and structural changes have not been shown. Research is needed to identify subgroup of progenitors, define role of EV and optimize cell product in order to develop efficient cell therapy for osteoarticular repair.
