Characterized by profound neuronal and glial depolarization, spreading depolarization (SD) orchestrates a cascade of metabolic and hemodynamic consequences. The relationship between SD and a spectrum of disorders, particularly migraine, unfolds a compelling yet complex narrative. Within the confines of this Collection, we invite researchers, clinicians, and academicians to traverse with us through the multifaceted domain of SD, exploring its mechanisms, relevance, and implications in both primary and secondary neurological disorders, thereby crafting a harmonious comprehension amidst the dissonance of existing theories and findings.
The realm of SD sparks compelling debates: Is canonical SD a clinically pertinent model of migraine, or is it a culprit of meningeal nociceptor activation? We invite experts to partake in debates that scrutinize the involvement and clinical relevance of SD, dissecting its role in the orchestration of migraine and illuminating the pathways of pain emanating from meningeal nociceptors. Comprehensive reviews unraveling the mechanisms of neuroinflammation in SD as well as its implications in primary and secondary neurological disorders are highly anticipated. We also welcome original articles traversing the horizons of SD, investigating its mechanistic pathways and clinical implications. Special emphasis on studies that delve into not only the causative facets of SD but also its consequences, therapeutic potentials, and predictive capabilities are particularly encouraged.
Through the meticulous construction of this article Collection, we aspire to weave together threads of understanding, questions, and novel insights regarding SD. We anticipate a vibrant confluence of diverse perspectives and robust research, fostering a rich scientific discourse and unraveling the mysteries enshrouding spreading depolarization.