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Single-Cell Epigenomics

Guest Editor:
Tamas Aranyi, MD, PhD, Institute of Molecular Life Sciences, Research Centre for Natural Sciences, HUN-REN, Hungary and Semmelweis University, Hungary

Submission Status: Open   |   Submission Deadline: 31 January 2025

New Content ItemEpigenetics & Chromatin is calling for submissions to our new Collection on "Single-Cell Epigenomics". This Collection aims to advance our understanding of cellular diversity and function through single-cell epigenomics.

Image credit: Tatiana Shepeleva /

About the collection

Single-cell epigenomics is a rapidly growing field at the intersection of genomics and epigenetics, focusing on understanding the epigenetic landscape at the individual cell level. This approach allows for the exploration of cellular heterogeneity within tissues and organisms, providing insights into gene regulation, cell fate determination, and disease mechanisms. Techniques such as single-cell bisulfite sequencing, single-cell chromatin accessibility assays (scATAC-seq), and single-cell Hi-C enable the study of DNA methylation, chromatin structure, and histone modifications in individual cells. Single-cell epigenomics has implications for developmental biology, cancer research, and regenerative medicine, among others. In addition, correlation of single-cell epigenomics and gene expression profile using bulk and other single-cell approaches reveals new layers of gene expression regulation, which can have tremendous research and medical relevance.

This Collection aims to advance our understanding of cellular diversity and function through single-cell epigenomics. Topics of interest include, but are not limited to:

• Epigenetic regulation of cellular identity and differentiation pathways
• Single-cell epigenetic profiling in disease states and pathological conditions
• Epigenetic mechanisms governing stem cell fate determination and lineage commitment
• Spatial organization of chromatin and its impact on gene expression in individual cells
• Single-cell epigenetic dynamics during cellular reprogramming and tissue regeneration
• Single-cell omics

There are currently no articles in this collection.

Submission Guidelines

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Before submitting your manuscript, please ensure you have read our submission guidelines. Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select "Single-Cell Epigenomics" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Guest Editor has no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests.