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Reviews from Journal of Experimental & Clinical Cancer Research

Below is a summary of all reviews published in JECCR

Page 6 of 7

  1. Thyroid malignant neoplasm develops from follicular or parafollicular thyroid cells. A higher proportion of anaplastic thyroid cancer has an adverse prognosis. New drugs are being used in clinical treatment. H...

    Authors: Mingxu Guan, Gaetano Romano, Roberta Coroniti and Earl E Henderson
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:91
  2. The DEAD-box family of RNA helicase is known to be required in virtually all cellular processes involving RNA, and p68 is a prototypic one of the family. Reports have indicated that in addition to ATPase and R...

    Authors: Ting-Yu Dai, Liu Cao, Zi-Chen Yang, Ya-Shu Li, Li Tan, Xin-Ze Ran and Chun-Meng Shi
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:64
  3. Snail1 is the founding member of the Snail superfamily of zinc-finger transcription factors, which also includes Snail2 (Slug) and Snail3 (Smuc). The superfamily is involved in cell differentiation and surviva...

    Authors: Samantha Kaufhold and Benjamin Bonavida
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:62
  4. MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-transcriptionally. miRNAs can be induced by a variety of stresses such as hypoxia, and are involved in diverse biological processe...

    Authors: Qin Qin, Wei Furong and Li Baosheng
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:50
  5. Liver metastases occur in 46-93% of patients with neuroendocrine neoplasms (NENs). Presence and extension of liver metastases are considered important prognostic factors, as they may significantly impair the p...

    Authors: Michela Del Prete, Francesco Fiore, Roberta Modica, Vincenzo Marotta, Francesca Marciello, Valeria Ramundo, Antonella Di Sarno, Annachiara Carratù, Chiara de Luca di Roseto, Salvatore Tafuto, Fabiana Tatangelo, Robero Baldelli, Annamaria Colao and Antongiulio Faggiano
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:43
  6. Although a number of in vitro studies have demonstrated the antiproliferative, anti-invasive, and antimetastatic effects of metformin in multiple cancer cell types, its cellular and molecular mechanisms of ant...

    Authors: Ruijin Shao, Xin Li, Yi Feng, Jin-Fang Lin and Håkan Billig
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:41
  7. Some cancers like melanoma and pancreatic and ovarian cancers, for example, commonly display resistance to chemotherapy, and this is the major obstacle to a better prognosis of patients. Frequently, literature...

    Authors: Evandro Luís Niero, Bianca Rocha-Sales, Camila Lauand, Beatriz Araujo Cortez, Marcelo Medina de Souza, Paula Rezende-Teixeira, Marcel Shiniti Urabayashi, Adam Arai Martens, Jorge Henrique Neves and Gláucia Maria Machado-Santelli
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:37
  8. Development of HPV-associated cancers not only depends on efficient negative regulation of cell cycle control that supports the accumulation of genetic damage, but also relies on immune evasion that enable the...

    Authors: Patrizia Vici, Luciano Mariani, Laura Pizzuti, Domenico Sergi, Luigi Di Lauro, Enrico Vizza, Federica Tomao, Silverio Tomao, Claudia Cavallotti, Francesca Paolini and Aldo Venuti
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:29
  9. Over the last decades, billions have been spent and huge efforts have been taken in basic and clinical cancer research [CA Cancer J Clin 63: 11-30]. About a decade ago, the arms race between drugs and cancer cell...

    Authors: Niels Eckstein, Lea Röper, Bodo Haas, Henrike Potthast, Ulrike Hermes, Christoph Unkrig, Frauke Naumann-Winter and Harald Enzmann
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:15
  10. Numerous studies have yielded inconclusive results regarding the relationship between anti-apoptotic protein Bcl-2 expression and the sensitivity to chemotherapy in the patients with breast cancer. The purpose...

    Authors: Dong Yang, Min-Bin Chen, Li-Qiang Wang, Lan Yang, Chao-Ying Liu and Pei-Hua Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:105
  11. Similar to protein-coding genes, miRNAs are also susceptible to epigenetic modulation. Although numerous miRNAs have been shown to be affected by DNA methylation, the regulatory mechanism of histone modificati...

    Authors: Xiaolan Liu, Xiaoyan Chen, Xinfang Yu, Yongguang Tao, Ann M Bode, Zigang Dong and Ya Cao
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:96
  12. Fluoropyrimidines, oxaliplatin, irinotecan and biologic therapies (Bevacizumab, Panitumumab, and Cetuximab) represent the backbone of metastatic colorectal cancer (CRC) treatment. The improvement in survival f...

    Authors: Giuseppe Tonini, Marco Imperatori, Bruno Vincenzi, Anna Maria Frezza and Daniele Santini
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:92
  13. The effectiveness of different breast cancer follow-up procedures to decrease breast cancer mortality are still an object of debate, even if intensive follow-up by imaging modalities is not recommended by inte...

    Authors: Isabella Sperduti, Patrizia Vici, Nicola Tinari, Teresa Gamucci, Michele De Tursi, Giada Cortese, Antonino Grassadonia, Stefano Iacobelli and Clara Natoli
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:89
  14. In 2013 there will be an estimated 22,240 new diagnoses and 14,030 deaths from ovarian cancer in the United States. Despite the improved surgical approach and the novel active drugs that are available today in...

    Authors: Federica Tomao, Anselmo Papa, Luigi Rossi, Martina Strudel, Patrizia Vici, Giuseppe Lo Russo and Silverio Tomao
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:48
  15. The recent studies have evaluated the relationship between BRCA1 expression and clinical outcome of chemotherapy (mainly focused on platinum-based and toxal-based treatment) in NSCLC patients, but the results wer...

    Authors: Yanlong Yang, Yuanliang Xie and Lei Xian
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:15
  16. Cdx2 is a homeobox domain-containing transcription factor that is important in the development and differentiation of the intestinal cells, and served as a potential biomarker of tumor progression in early int...

    Authors: Xiao-Tong Wang, Wei-Yuan Wei, Fan-Biao Kong, Chao Lian, Wen Luo, Qiang Xiao and Yu-Bo Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:98
  17. Homeodomain-interacting protein kinase 2 (HIPK2) is a multitalented protein that exploits its kinase activity to modulate key molecular pathways in cancer to restrain tumor growth and induce response to therap...

    Authors: Gabriella D’Orazi, Cinzia Rinaldo and Silvia Soddu
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:63
  18. MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the posttranscriptional level. The dysregulation of miRNAs has been linked to a series of diseases, including various ty...

    Authors: Ruimin Ma, Tao Jiang and Xixiong Kang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:38
  19. Ovarian cancer is the most lethal gynecologic malignancy. It appears that the vast majority of what seem to be primary epithelial ovarian and primary peritoneal carcinomas is, in fact, secondary from the fimbr...

    Authors: Ayako Kim, Yutaka Ueda, Tetsuji Naka and Takayuki Enomoto
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:14
  20. Adjuvant chemotherapy for non-small-cell lung carcinoma (NSCLC) is a debated issue in clinical oncology. Although it is considered a standard for resected stage II-IIIA patients according to the available guid...

    Authors: Maria Bonomi, Sara Pilotto, Michele Milella, Francesco Massari, Sara Cingarlini, Matteo Brunelli, Marco Chilosi, Giampaolo Tortora and Emilio Bria
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:115
  21. Increased polyamine concentrations in the blood and urine of cancer patients reflect the enhanced levels of polyamine synthesis in cancer tissues arising from increased activity of enzymes responsible for poly...

    Authors: Kuniyasu Soda
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:95
  22. Breast and ovarian cancers are among the 10 leading cancer types in females with mortalities of 15% and 6%, respectively. Despite tremendous efforts to conquer malignant diseases, the war on cancer declared by Ri...

    Authors: Niels Eckstein
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:91
  23. Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. It is also one of the most studied topics among cell biologists. An understanding of the unde...

    Authors: Rebecca SY Wong
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:87
  24. Maintenance therapy is emerging as a treatment strategy in the management of advanced non small cell lung cancer (NSCLC). Initial trials addressing the question of duration of combination chemotherapy failed t...

    Authors: Silvia Novello, Michele Milella, Marcello Tiseo, Giuseppe Banna, Diego Cortinovis, Massimo Di Maio, Marina Garassino, Paolo Maione, Olga Martelli, Tiziana Vavalà and Emilio Bria
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:50
  25. Over-expressed in numerous cancers, Ubiquitin-like containing PHD Ring Finger 1 (UHRF1, also known as ICBP90 or Np95) is characterized by a SRA domain (Set and Ring Associated) which is found only in the UHRF fam...

    Authors: Mahmoud Alhosin, Tanveer Sharif, Marc Mousli, Nelly Etienne-Selloum, Guy Fuhrmann, Valérie B Schini-Kerth and Christian Bronner
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:41
  26. Streptococcus bovis (S. bovis) bacteria are associated with colorectal cancer and adenoma. S. bovis is currently named S. gallolyticus. 25 to 80% of patients with S. bovis/gallolyticus bacteremia have concomitant...

    Authors: Ahmed S Abdulamir, Rand R Hafidh and Fatimah Abu Bakar
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:11
  27. Stem cells are a relevant source of information about cellular differentiation, molecular processes and tissue homeostasis, but also one of the most putative biological tools to treat degenerative diseases. Th...

    Authors: Daniele Lodi, Tommaso Iannitti and Beniamino Palmieri
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:9
  28. The cellular apoptosis susceptibility (CSE1L/CAS) protein is highly expressed in cancer, and its expression is positively correlated with high cancer stage, high cancer grade, and worse outcomes of patients. C...

    Authors: Cheng-Jeng Tai, Chung-Huei Hsu, Shing-Chuan Shen, Woan-Ruoh Lee and Ming-Chung Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:110
  29. The main hindrance to the diffusion of proton therapy facilities is the high cost for gantry installations. An alternative technical option is provided by fixed-beam treatment rooms, where the patient is rotat...

    Authors: Salvatore Devicienti, Lidia Strigari, Marco D'Andrea, Marcello Benassi, Vincenzo Dimiccoli and Maurizio Portaluri
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:47
  30. The past two decades have witnessed an increasing appreciation of the role of the tumor microenvironment, of genetic and epigenetic alterations in normal cells adjacent to tumors and of the migration of normal...

    Authors: Razvan T Radulescu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:30
  31. Perineural invasion is a common path for cholangiocarcinoma (CCA) metastasis, and it is highly correlated with postoperative recurrence and poor prognosis. It is often an early event in a disease that is commo...

    Authors: Fang-Zhen Shen, Bing-Yuan Zhang, Yu-Jie Feng, Zhuo-Xia Jia, Bing An, Chang-Chang Liu, Xi-Yun Deng, Anil D Kulkarni and Yun Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:24
  32. Lymph node status is an important prognostic factor and a criterion for adjuvant therapy in uterine cancers. While detection of micrometastases by ultrastaging techniques is correlated to prognosis in several ...

    Authors: Corinne Bézu, Charles Coutant, Marcos Ballester, Jean-Guillaume Feron, Roman Rouzier, Serge Uzan and Emile Daraï
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:5
  33. To establish a relationship between esophageal squamous cell diseases and the expression of human telomerase reverse transcriptase (hTERT) and Eyes absent 4 (EYA4) mRNA in peripheral blood mononuclear cells.

    Authors: Hao Li, Tao Yu Diao, Zhi Ying Zhou, Fang Yan Yang, Qing Ma and Qing Hui Li
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:145
  34. To investigate prostate cancer (Pca) risk in relation to estrogen metabolism, expressed as urinary 2-hydroxyestrone (2-OHE1), 16α-hydroxyestrone (16α-OHE1) and 2-OHE1 to 16α-OHE1 ratio.

    Authors: Maddalena Barba, Li Yang, Holger J Schünemann, Francesca Sperati, Sara Grioni, Saverio Stranges, Kim C Westerlind, Giovanni Blandino, Michele Gallucci, Rossella Lauria, Luca Malorni and Paola Muti
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:135
  35. Chromophobe renal cell carcinoma (ChRCC) is a subtype of renal cell carcinoma (RCC). ChRCC is diagnosed mainly in 6th decade of life. An incidence of ChRCC is similar in both men and woman. Eighty six percent ...

    Authors: Rafał Stec, Bartłomiej Grala, Michał Mączewski, Lubomir Bodnar and Cezary Szczylik
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:134
  36. The treatment of soft tissue tumors needs the coordinated adoption of surgery with radiation therapy and eventually, chemotherapy. The radiation therapy (delivered with a linear accelerator) can be preoperativ...

    Authors: Enrico P Spugnini, Gennaro Citro and Alfonso Baldi
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:114
  37. Genetic instability is known as a cause of oncogenesis. Though Rad18 is reported to function in a post replication mismatch repair system, the relation between the status of Rad18 and human tumorigenesis has n...

    Authors: Tadahiko Nakamura, Shinji Ishikawa, Yoshikatsu Koga, Youhei Nagai, Yu Imamura, Kouei Ikeda, Takeshi Mori, Hiroaki Nomori and Hideo Baba
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:106
  38. Molecularly targeted agents for the treatment of solid tumors had entered the market in the last 5 years, with a great impact upon both the scientific community and the society. Many randomized phase III trial...

    Authors: Emilio Bria, Massimo Di Maio, Paolo Carlini, Federica Cuppone, Diana Giannarelli, Francesco Cognetti and Michele Milella
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:66
  39. Tumours are classified according to the most differentiated cells with the exception of carcinomas where a few tumour cells show neuroendocrine differentiation. In this case these cells are regarded as rediffe...

    Authors: Helge L Waldum, Arne K Sandvik, Eiliv Brenna, Reidar Fossmark, Gunnar Qvigstad and Jun Soga
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:70