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Reviews from Journal of Experimental & Clinical Cancer Research

Below is a summary of all reviews published in JECCR

Page 3 of 4

  1. A widespread decrease of mature microRNAs is often observed in human malignancies giving them potential to act as tumor suppressors. Thus, microRNAs may be potential targets for cancer therapy. The global miRN...

    Authors: Aymone Gurtner, Emmanuela Falcone, Francesca Garibaldi and Giulia Piaggio

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:45

    Content type: Review

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  2. Acting as inflammatory mediators, tumor oncogenes or suppressors, microRNAs are involved in cell survival, death, epithelial–mesenchymal transition and metastasis, etc. Investigating the communication between ...

    Authors: Yudan Chi and Dongming Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:43

    Content type: Review

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  3. Temozolomide (TMZ), an alkylating agent, is widely used for treating primary and recurrent high-grade gliomas. However, the efficacy of TMZ is often limited by the development of resistance. Recently, studies ...

    Authors: Yuanliang Yan, Zhijie Xu, Shuang Dai, Long Qian, Lunquan Sun and Zhicheng Gong

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:23

    Content type: Review

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  4. Pigment epithelium-derived factor (PEDF) is a secreted glycoprotein and a non-inhibitory member of the serine protease inhibitor (serpin) family. It is widely expressed in human fetal and adult tissues but its...

    Authors: Louiza Belkacemi and Shaun Xiaoliu Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:4

    Content type: Review

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  5. Despite the global decline in the incidence and mortality of gastric cancer, it remains one of the most common malignant tumors of the digestive system. Although surgical resection is the preferred treatment f...

    Authors: Wenting Xu, Zhen Yang and Nonghua Lu

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:1

    Content type: Review

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  6. The treatment of cancer presents a clinical challenge both in human and veterinary medicine. Chemotherapy protocols require the use of toxic drugs that are not always specific, do not selectively target cancer...

    Authors: Megan Walsh, Stefano Fais, Enrico Pierluigi Spugnini, Salvador Harguindey, Tareq Abu Izneid, Licia Scacco, Paula Williams, Cinzia Allegrucci, Cyril Rauch and Ziad Omran

    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:93

    Content type: Review

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  7. Increased understanding of the genetic aetiology of advanced non-small-cell lung cancer (aNSCLC) has facilitated personalised therapies that target specific molecular aberrations associated with the disease. B...

    Authors: James Sherwood, Simon Dearden, Marianne Ratcliffe and Jill Walker

    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:92

    Content type: Review

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  8. Zebrafish represent a vertebrate model organism that has been widely, and increasingly, employed over the last decade in the study of developmental processes, wound healing, microbe-host interactions, and drug...

    Authors: Shuai Zhao, Jian Huang and Jun Ye

    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:80

    Content type: Review

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  9. A class of small non-coding RNAs, the microRNAs (miRNAs), have recently attracted great attention in cancer research since they play a central role in regulation of gene-expression and miRNA aberrant expressio...

    Authors: Germana Falcone, Armando Felsani and Igea D’Agnano

    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:32

    Content type: Review

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  10. Thyroid malignant neoplasm develops from follicular or parafollicular thyroid cells. A higher proportion of anaplastic thyroid cancer has an adverse prognosis. New drugs are being used in clinical treatment. H...

    Authors: Mingxu Guan, Gaetano Romano, Roberta Coroniti and Earl E Henderson

    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:91

    Content type: Review

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  11. The DEAD-box family of RNA helicase is known to be required in virtually all cellular processes involving RNA, and p68 is a prototypic one of the family. Reports have indicated that in addition to ATPase and R...

    Authors: Ting-Yu Dai, Liu Cao, Zi-Chen Yang, Ya-Shu Li, Li Tan, Xin-Ze Ran and Chun-Meng Shi

    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:64

    Content type: Review

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  12. Snail1 is the founding member of the Snail superfamily of zinc-finger transcription factors, which also includes Snail2 (Slug) and Snail3 (Smuc). The superfamily is involved in cell differentiation and surviva...

    Authors: Samantha Kaufhold and Benjamin Bonavida

    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:62

    Content type: Review

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  13. MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-transcriptionally. miRNAs can be induced by a variety of stresses such as hypoxia, and are involved in diverse biological processe...

    Authors: Qin Qin, Wei Furong and Li Baosheng

    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:50

    Content type: Review

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  14. Liver metastases occur in 46-93% of patients with neuroendocrine neoplasms (NENs). Presence and extension of liver metastases are considered important prognostic factors, as they may significantly impair the p...

    Authors: Michela Del Prete, Francesco Fiore, Roberta Modica, Vincenzo Marotta, Francesca Marciello, Valeria Ramundo, Antonella Di Sarno, Annachiara Carratù, Chiara de Luca di Roseto, Salvatore Tafuto, Fabiana Tatangelo, Robero Baldelli, Annamaria Colao and Antongiulio Faggiano

    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:43

    Content type: Review

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  15. Although a number of in vitro studies have demonstrated the antiproliferative, anti-invasive, and antimetastatic effects of metformin in multiple cancer cell types, its cellular and molecular mechanisms of ant...

    Authors: Ruijin Shao, Xin Li, Yi Feng, Jin-Fang Lin and Håkan Billig

    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:41

    Content type: Review

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  16. Some cancers like melanoma and pancreatic and ovarian cancers, for example, commonly display resistance to chemotherapy, and this is the major obstacle to a better prognosis of patients. Frequently, literature...

    Authors: Evandro Luís Niero, Bianca Rocha-Sales, Camila Lauand, Beatriz Araujo Cortez, Marcelo Medina de Souza, Paula Rezende-Teixeira, Marcel Shiniti Urabayashi, Adam Arai Martens, Jorge Henrique Neves and Gláucia Maria Machado-Santelli

    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:37

    Content type: Review

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  17. Development of HPV-associated cancers not only depends on efficient negative regulation of cell cycle control that supports the accumulation of genetic damage, but also relies on immune evasion that enable the...

    Authors: Patrizia Vici, Luciano Mariani, Laura Pizzuti, Domenico Sergi, Luigi Di Lauro, Enrico Vizza, Federica Tomao, Silverio Tomao, Claudia Cavallotti, Francesca Paolini and Aldo Venuti

    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:29

    Content type: Review

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  18. Over the last decades, billions have been spent and huge efforts have been taken in basic and clinical cancer research [CA Cancer J Clin 63: 11-30]. About a decade ago, the arms race between drugs and cancer cell...

    Authors: Niels Eckstein, Lea Röper, Bodo Haas, Henrike Potthast, Ulrike Hermes, Christoph Unkrig, Frauke Naumann-Winter and Harald Enzmann

    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:15

    Content type: Review

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  19. Numerous studies have yielded inconclusive results regarding the relationship between anti-apoptotic protein Bcl-2 expression and the sensitivity to chemotherapy in the patients with breast cancer. The purpose...

    Authors: Dong Yang, Min-Bin Chen, Li-Qiang Wang, Lan Yang, Chao-Ying Liu and Pei-Hua Lu

    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:105

    Content type: Review

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  20. Similar to protein-coding genes, miRNAs are also susceptible to epigenetic modulation. Although numerous miRNAs have been shown to be affected by DNA methylation, the regulatory mechanism of histone modificati...

    Authors: Xiaolan Liu, Xiaoyan Chen, Xinfang Yu, Yongguang Tao, Ann M Bode, Zigang Dong and Ya Cao

    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:96

    Content type: Review

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  21. Fluoropyrimidines, oxaliplatin, irinotecan and biologic therapies (Bevacizumab, Panitumumab, and Cetuximab) represent the backbone of metastatic colorectal cancer (CRC) treatment. The improvement in survival f...

    Authors: Giuseppe Tonini, Marco Imperatori, Bruno Vincenzi, Anna Maria Frezza and Daniele Santini

    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:92

    Content type: Review

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  22. The effectiveness of different breast cancer follow-up procedures to decrease breast cancer mortality are still an object of debate, even if intensive follow-up by imaging modalities is not recommended by inte...

    Authors: Isabella Sperduti, Patrizia Vici, Nicola Tinari, Teresa Gamucci, Michele De Tursi, Giada Cortese, Antonino Grassadonia, Stefano Iacobelli and Clara Natoli

    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:89

    Content type: Review

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  23. In 2013 there will be an estimated 22,240 new diagnoses and 14,030 deaths from ovarian cancer in the United States. Despite the improved surgical approach and the novel active drugs that are available today in...

    Authors: Federica Tomao, Anselmo Papa, Luigi Rossi, Martina Strudel, Patrizia Vici, Giuseppe Lo Russo and Silverio Tomao

    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:48

    Content type: Review

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  24. The recent studies have evaluated the relationship between BRCA1 expression and clinical outcome of chemotherapy (mainly focused on platinum-based and toxal-based treatment) in NSCLC patients, but the results wer...

    Authors: Yanlong Yang, Yuanliang Xie and Lei Xian

    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:15

    Content type: Review

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  25. Cdx2 is a homeobox domain-containing transcription factor that is important in the development and differentiation of the intestinal cells, and served as a potential biomarker of tumor progression in early int...

    Authors: Xiao-Tong Wang, Wei-Yuan Wei, Fan-Biao Kong, Chao Lian, Wen Luo, Qiang Xiao and Yu-Bo Xie

    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:98

    Content type: Review

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  26. Homeodomain-interacting protein kinase 2 (HIPK2) is a multitalented protein that exploits its kinase activity to modulate key molecular pathways in cancer to restrain tumor growth and induce response to therap...

    Authors: Gabriella D’Orazi, Cinzia Rinaldo and Silvia Soddu

    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:63

    Content type: Review

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  27. MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the posttranscriptional level. The dysregulation of miRNAs has been linked to a series of diseases, including various ty...

    Authors: Ruimin Ma, Tao Jiang and Xixiong Kang

    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:38

    Content type: Review

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  28. Ovarian cancer is the most lethal gynecologic malignancy. It appears that the vast majority of what seem to be primary epithelial ovarian and primary peritoneal carcinomas is, in fact, secondary from the fimbr...

    Authors: Ayako Kim, Yutaka Ueda, Tetsuji Naka and Takayuki Enomoto

    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:14

    Content type: Review

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  29. Adjuvant chemotherapy for non-small-cell lung carcinoma (NSCLC) is a debated issue in clinical oncology. Although it is considered a standard for resected stage II-IIIA patients according to the available guid...

    Authors: Maria Bonomi, Sara Pilotto, Michele Milella, Francesco Massari, Sara Cingarlini, Matteo Brunelli, Marco Chilosi, Giampaolo Tortora and Emilio Bria

    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:115

    Content type: Review

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  30. Increased polyamine concentrations in the blood and urine of cancer patients reflect the enhanced levels of polyamine synthesis in cancer tissues arising from increased activity of enzymes responsible for poly...

    Authors: Kuniyasu Soda

    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:95

    Content type: Review

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  31. Breast and ovarian cancers are among the 10 leading cancer types in females with mortalities of 15% and 6%, respectively. Despite tremendous efforts to conquer malignant diseases, the war on cancer declared by Ri...

    Authors: Niels Eckstein

    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:91

    Content type: Review

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  32. Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. It is also one of the most studied topics among cell biologists. An understanding of the unde...

    Authors: Rebecca SY Wong

    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:87

    Content type: Review

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  33. Maintenance therapy is emerging as a treatment strategy in the management of advanced non small cell lung cancer (NSCLC). Initial trials addressing the question of duration of combination chemotherapy failed t...

    Authors: Silvia Novello, Michele Milella, Marcello Tiseo, Giuseppe Banna, Diego Cortinovis, Massimo Di Maio, Marina Garassino, Paolo Maione, Olga Martelli, Tiziana Vavalà and Emilio Bria

    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:50

    Content type: Review

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  34. Over-expressed in numerous cancers, Ubiquitin-like containing PHD Ring Finger 1 (UHRF1, also known as ICBP90 or Np95) is characterized by a SRA domain (Set and Ring Associated) which is found only in the UHRF fam...

    Authors: Mahmoud Alhosin, Tanveer Sharif, Marc Mousli, Nelly Etienne-Selloum, Guy Fuhrmann, Valérie B Schini-Kerth and Christian Bronner

    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:41

    Content type: Review

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  35. Streptococcus bovis (S. bovis) bacteria are associated with colorectal cancer and adenoma. S. bovis is currently named S. gallolyticus. 25 to 80% of patients with S. bovis/gallolyticus bacteremia have concomitant...

    Authors: Ahmed S Abdulamir, Rand R Hafidh and Fatimah Abu Bakar

    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:11

    Content type: Review

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  36. Stem cells are a relevant source of information about cellular differentiation, molecular processes and tissue homeostasis, but also one of the most putative biological tools to treat degenerative diseases. Th...

    Authors: Daniele Lodi, Tommaso Iannitti and Beniamino Palmieri

    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:9

    Content type: Review

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  37. The cellular apoptosis susceptibility (CSE1L/CAS) protein is highly expressed in cancer, and its expression is positively correlated with high cancer stage, high cancer grade, and worse outcomes of patients. C...

    Authors: Cheng-Jeng Tai, Chung-Huei Hsu, Shing-Chuan Shen, Woan-Ruoh Lee and Ming-Chung Jiang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:110

    Content type: Review

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  38. The main hindrance to the diffusion of proton therapy facilities is the high cost for gantry installations. An alternative technical option is provided by fixed-beam treatment rooms, where the patient is rotat...

    Authors: Salvatore Devicienti, Lidia Strigari, Marco D'Andrea, Marcello Benassi, Vincenzo Dimiccoli and Maurizio Portaluri

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:47

    Content type: Review

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  39. The past two decades have witnessed an increasing appreciation of the role of the tumor microenvironment, of genetic and epigenetic alterations in normal cells adjacent to tumors and of the migration of normal...

    Authors: Razvan T Radulescu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:30

    Content type: Review

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  40. Perineural invasion is a common path for cholangiocarcinoma (CCA) metastasis, and it is highly correlated with postoperative recurrence and poor prognosis. It is often an early event in a disease that is commo...

    Authors: Fang-Zhen Shen, Bing-Yuan Zhang, Yu-Jie Feng, Zhuo-Xia Jia, Bing An, Chang-Chang Liu, Xi-Yun Deng, Anil D Kulkarni and Yun Lu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:24

    Content type: Review

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  41. Lymph node status is an important prognostic factor and a criterion for adjuvant therapy in uterine cancers. While detection of micrometastases by ultrastaging techniques is correlated to prognosis in several ...

    Authors: Corinne Bézu, Charles Coutant, Marcos Ballester, Jean-Guillaume Feron, Roman Rouzier, Serge Uzan and Emile Daraï

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:5

    Content type: Review

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