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Reviews from Journal of Experimental & Clinical Cancer Research

Below is a summary of all reviews published in JECCR. 

Page 1 of 4

  1. The promising expectations about personalized medicine have opened the path to routine large-scale sequencing and increased the importance of genetic counseling for hereditary cancers, among which hereditary b...

    Authors: Giulia Federici and Silvia Soddu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:46

    Content type: Review

    Published on:

  2. Hypoxia is a classic characteristic of the tumor microenvironment with a significant impact on cancer progression and therapeutic response. Hypoxia-inducible factor-1 alpha (HIF-1α), the most important transcr...

    Authors: Xiafeng Peng, Han Gao, Rui Xu, Huiyu Wang, Jie Mei and Chaoying Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:27

    Content type: Review

    Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:45

  4. Growing evidence showed the increased prevalence of cancer incidents, particularly colorectal cancer, among type 2 diabetic mellitus patients. Antidiabetic medications such as, insulin, sulfonylureas, dipeptyl...

    Authors: Muhamad Noor Alfarizal Kamarudin, Md. Moklesur Rahman Sarker, Jin-Rong Zhou and Ishwar Parhar

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:491

    Content type: Review

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  5. Molecular targeted therapy for advanced hepatocellular carcinoma (HCC) has changed markedly. Although sorafenib was used in clinical practice as the first molecular targeted agent in 2007, the SHARPE and Asian...

    Authors: Ziyu Liu, Yan Lin, Jinyan Zhang, Yumei Zhang, Yongqiang Li, Zhihui Liu, Qian Li, Ming Luo, Rong Liang and Jiazhou Ye

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:447

    Content type: Review

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  7. The monocyte chemoattractant protein-induced protein (MCPIP) family consists of 4 members (MCPIP1–4) encoded by the ZC3h12A-D genes, which are located at different loci. The common features of MCPIP proteins are ...

    Authors: Katarzyna Miekus, Jerzy Kotlinowski, Agata Lichawska-Cieslar, Janusz Rys and Jolanta Jura

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:421

    Content type: Review

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  8. Until very few years ago, the oncology community dogmatically excluded any clinical potential for immunotherapy in controlling brain metastases. Therefore, despite the significant therapeutic efficacy of monoc...

    Authors: Anna Maria Di Giacomo, Monica Valente, Alfonso Cerase, Maria Fortunata Lofiego, Francesca Piazzini, Luana Calabrò, Elisabetta Gambale, Alessia Covre and Michele Maio

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:419

    Content type: Review

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  9. Iron, an indispensable element for life, is involved in all kinds of important physiological activities. Iron promotes cell growth and proliferation, but it also causes oxidative stress damage. The body has a ...

    Authors: Fang Wang, Huanhuan Lv, Bin Zhao, Liangfu Zhou, Shenghang Wang, Jie Luo, Junyu Liu and Peng Shang

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:406

    Content type: Review

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  10. T cells play important roles in anti-tumor immunity. Emerging evidence has revealed that distinct metabolic changes impact the activation and differentiation of T cells. Tailoring immune responses by manipulat...

    Authors: Zhongping Yin, Ling Bai, Wei Li, Tanlun Zeng, Huimin Tian and Jiuwei Cui

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:403

    Content type: Review

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  11. Hepatocellular carcinoma (HCC) ranks the most common primary liver malignancy and the third leading cause of tumor-related mortality worldwide. Unfortunately, despite advances in HCC treatment, less than 40% o...

    Authors: Yaojie Fu, Shanshan Liu, Shan Zeng and Hong Shen

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:396

    Content type: Review

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  12. Survivin (also named BIRC5) is a well-known cancer therapeutic target. Since its discovery more than two decades ago, the use of survivin as a target for cancer therapeutics has remained a central goal of surv...

    Authors: Fengzhi Li, Ieman Aljahdali and Xiang Ling

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:368

    Content type: Review

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  13. Tumor heterogeneity results in differential response to therapy due to the existence of plastic tumor cells, called cancer stem cells (CSCs), which exhibit the property of resistance to therapy, invasion and m...

    Authors: Pavana Thomas, Annapurna Pranatharthi, Cecil Ross and Sweta Srivastava

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:328

    Content type: Review

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  14. Malignant tumors are often multifactorial. Epidemiological studies have shown that hyperglycemia raises the prevalence and mortality of certain malignancies, like breast, liver, bladder, pancreatic, colorectal...

    Authors: Wenjie Li, Xuehui Zhang, Hui Sang, Ying Zhou, Chunyu Shang, Yongqing Wang and Hong Zhu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:327

    Content type: Review

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  15. Numerous studies have presented that curcumin could have a positive effect in the prevention of cancer and then in tumor therapy. Several hypotheses have highlighted that curcumin could decreases tumor growth ...

    Authors: Alexandre Vallée, Yves Lecarpentier and Jean-Noël Vallée

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:323

    Content type: Review

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  16. Drug resistance represents the major reason of pharmacological treatment failure. It is supported by a broad spectrum of mechanisms, whose molecular bases have been frequently correlated to aberrant protein ph...

    Authors: Christian Borgo and Maria Ruzzene

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:287

    Content type: Review

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  17. Gliomas represent the most common type of malignant brain tumor, among which, glioblastoma remains a clinical challenge with limited treatment options and dismal prognosis. It has been shown that the dysregula...

    Authors: Fangling Cheng and Dongsheng Guo

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:270

    Content type: Review

    Published on:

  18. Immunotherapy has become an established pillar of cancer treatment improving the prognosis of many patients with a broad variety of hematological and solid malignancies. The two main drivers behind this succes...

    Authors: Stephan Kruger, Matthias Ilmer, Sebastian Kobold, Bruno L. Cadilha, Stefan Endres, Steffen Ormanns, Gesa Schuebbe, Bernhard W. Renz, Jan G. D’Haese, Hans Schloesser, Volker Heinemann, Marion Subklewe, Stefan Boeck, Jens Werner and Michael von Bergwelt-Baildon

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:268

    Content type: Review

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  19. Autophagy is a catabolic process whose activation may help cancer cells to adapt to cellular stress although, in some instances, it can induce cell death. Autophagy stimulation or inhibition has been considere...

    Authors: Mara Cirone, Maria Saveria Gilardini Montani, Marisa Granato, Alessia Garufi, Alberto Faggioni and Gabriella D’Orazi

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:262

    Content type: Review

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  22. Because of the complexity of the blood-brain barrier (BBB), brain tumors, especially the most common and aggressive primary malignant tumor type arising from the central nervous system (CNS), glioblastoma, rem...

    Authors: George E. D. Petrescu, Alexandru A. Sabo, Ligia I. Torsin, George A. Calin and Mihnea P. Dragomir

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:231

    Content type: Review

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  23. Stromal stimuli mediated by growth factor receptors, leading to ligand-independent activation of steroid hormone receptors, have long been implicated in development of breast cancer resistance to endocrine the...

    Authors: Dominika Piasecka, Marcin Braun, Kamila Kitowska, Kamil Mieczkowski, Radzislaw Kordek, Rafal Sadej and Hanna Romanska

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:230

    Content type: Review

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  24. Reprogramming of cancer metabolism is a newly recognized hallmark of malignancy. The aberrant glucose metabolism is associated with dramatically increased bioenergetics, biosynthetic, and redox demands, which ...

    Authors: Jinguan Lin, Longzheng Xia, Jiaxin Liang, Yaqian Han, Heran Wang, Linda Oyang, Shiming Tan, Yutong Tian, Shan Rao, Xiaoyan Chen, Yanyan Tang, Min Su, Xia Luo, Ying Wang, Hui Wang, Yujuan Zhou…

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:218

    Content type: Review

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  25. Growing preclinical evidence shows that short-term fasting (STF) protects from toxicity while enhancing the efficacy of a variety of chemotherapeutic agents in the treatment of various tumour types. STF reinfo...

    Authors: Stefanie de Groot, Hanno Pijl, Jacobus J. M. van der Hoeven and Judith R. Kroep

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:209

    Content type: Review

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  26. Hepatocellular carcinoma (HCC) is one of the most notable lethal malignancies worldwide. However, the molecular mechanisms involved in the initiation and progression of this disease remain poorly understood. O...

    Authors: Haoming Mai, Bin Zhou, Li Liu, Fu Yang, Carly Conran, Yuan Ji, Jinlin Hou and Deke Jiang

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:198

    Content type: Review

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    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:352

  27. Triple negative breast cancer (TNBC), which is typically lack of expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), represents the most aggre...

    Authors: Jiang-Jiang Qin, Li Yan, Jia Zhang and Wei-Dong Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:195

    Content type: Review

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  28. Cancer-associated fibroblasts (CAFs) plays an essential role in cancer cell growth, metabolism and immunoreaction. Autophagy is an intracellular self-degradative process that balances cell energy source and re...

    Authors: Yuanliang Yan, Xi Chen, Xiang Wang, Zijin Zhao, Wenfeng Hu, Shuangshuang Zeng, Jie Wei, Xue Yang, Long Qian, Shuyi Zhou, Lunquan Sun, Zhicheng Gong and Zhijie Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:171

    Content type: Review

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  29. Pancreatic cancer is one of the most lethal type of cancers, with an overall five-year survival rate of less than 5%. It is usually diagnosed at an advanced stage with limited therapeutic options. To date, no ...

    Authors: Chin-King Looi, Felicia Fei-Lei Chung, Chee-Onn Leong, Shew-Fung Wong, Rozita Rosli and Chun-Wai Mai

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:162

    Content type: Review

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  30. Cancer is currently the second leading cause of death globally and is expected to be responsible for approximately 9.6 million deaths in 2018. With an unprecedented understanding of the molecular pathways that...

    Authors: N. A. Seebacher, A. E. Stacy, G. M. Porter and A. M. Merlot

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:156

    Content type: Review

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  31. The recent developments in immuno-oncology have opened an unprecedented avenue for the emergence of vaccine strategies. Therapeutic DNA cancer vaccines are now considered a very promising strategy to activate ...

    Authors: Alessandra Lopes, Gaëlle Vandermeulen and Véronique Préat

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:146

    Content type: Review

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  32. Immune checkpoint inhibitor therapy has changed clinical practice for patients with different cancers, since these agents have demonstrated a significant improvement of overall survival and are effective in ma...

    Authors: Francesca Di Modugno, Cristina Colosi, Paola Trono, Giuseppe Antonacci, Giancarlo Ruocco and Paola Nisticò

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:117

    Content type: Review

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  33. The p38 mitogen-activated protein kinase (p38MAPK) pathway has been implicated in a variety of pathological conditions including inflammation and metastasis. Post-transcriptional regulation of genes harboring ...

    Authors: Sourabh Soni, Prince Anand and Yogendra S. Padwad

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:121

    Content type: Review

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  34. The extracellular matrix (ECM) plays an important role in cancer progression. It can be divided into the basement membrane (BM) that supports epithelial/endothelial cell behavior and the interstitial matrix (I...

    Authors: Neel I. Nissen, Morten Karsdal and Nicholas Willumsen

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:115

    Content type: Review

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  35. Novel therapeutic strategies are urgently needed for the treatment of metastatic Urothelial Bladder Cancer. DNA damaging repair (DDR) targeting has been introduced in cinical trials for bladder cancer patients...

    Authors: Daniela Criscuolo, Francesco Morra, Riccardo Giannella, Roberta Visconti, Aniello Cerrato and Angela Celetti

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:91

    Content type: Review

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  36. PD-1/PD-L1 checkpoint blockades have achieved significant progress in several kinds of tumours. Pembrolizumab, which targets PD-1, has been approved as a first-line treatment for advanced non-small cell lung c...

    Authors: Xin Wang, Gaochao Guo, Hui Guan, Yang Yu, Jie Lu and Jinming Yu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:87

    Content type: Review

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  38. Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin st...

    Authors: Stefano Cacchione, Annamaria Biroccio and Angela Rizzo

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:21

    Content type: Review

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  39. RANKL/RANK/OPG system consists of three essential signaling molecules: i) the receptor activator of nuclear factor (NF)-kB-ligand (RANKL), ii) the receptor activator of NF-kB (RANK), and iii) the soluble decoy...

    Authors: Marco Infante, Alessandra Fabi, Francesco Cognetti, Stefania Gorini, Massimiliano Caprio and Andrea Fabbri

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:12

    Content type: Review

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  40. Pancreatic cancer (PC) is among foremost causes of cancer related deaths worldwide due to generic symptoms, lack of effective screening strategies and resistance to chemo- and radiotherapies. The risk factors ...

    Authors: Ramesh Pothuraju, Satyanarayana Rachagani, Wade M. Junker, Sanjib Chaudhary, Viswanathan Saraswathi, Sukhwinder Kaur and Surinder K. Batra

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:319

    Content type: Review

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  41. Resistance to regulated cell death is one of the hallmarks of human cancers; it maintains cell survival and significantly limits the effectiveness of conventional drug therapy. Leukemia represents a class of h...

    Authors: Xianbo Huang, Feng Xiao, Yuan Li, Wenbin Qian, Wei Ding and Xiujin Ye

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:310

    Content type: Review

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  43. Most chemotherapeutics elevate intracellular levels of reactive oxygen species (ROS), and many can alter redox-homeostasis of cancer cells. It is widely accepted that the anticancer effect of these chemotherap...

    Authors: Haotian Yang, Rehan M Villani, Haolu Wang, Matthew J Simpson, Michael S Roberts, Min Tang and Xiaowen Liang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:266

    Content type: Review

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  44. The mechanism by which c-Myc exerts its oncogenic functions is not completely clear and different hypotheses are still under investigation. The knowledge of the capacity of c-Myc to bind exclusively E-box sequ...

    Authors: Matteo Caforio, Cristina Sorino, Stefano Iacovelli, Maurizio Fanciulli, Franco Locatelli and Valentina Folgiero

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:239

    Content type: Review

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  45. Non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer cases, and it is one of the leading causes of cancer death in both men and women worldwide due to diagnosis in the advanced stag...

    Authors: Hongmei Zheng, Yuting Zhan, Sile Liu, Junmi Lu, Jiadi Luo, Juan Feng and Songqing Fan

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:226

    Content type: Review

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  46. Phosphatase and tensin homologue (PTEN) triggers a battery of intracellular signaling pathways, especially PI3K/Akt, playing important roles in the pathogenesis of multiple diseases, such as cancer, neurodevel...

    Authors: Wang Li, Ting Zhang, Lianying Guo and Lin Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:223

    Content type: Review

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  47. Hepatocellular carcinoma (HCC) is a highly malignant disease with a poor prognosis and high mortality due to a low early diagnosis rate, resistance to systemic treatments and progression to late-stage liver di...

    Authors: Jie Li, Xu Han, Xiaona Yu, Zongzhen Xu, Guangsheng Yang, Bingqi Liu and Peng Xiu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:213

    Content type: Review

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  48. Circular RNAs (circRNAs) are a type of noncoding RNAs with a closed loop structure. With the development of high-throughput sequencing, massive circRNAs have been discovered in tumorous tissues. Emerging evide...

    Authors: Xuehui Wang and Lin Fang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:206

    Content type: Review

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  49. Epithelial-to-mesenchymal transition (EMT) is a complex process involving multiple genes, steps and stages. It refers to the disruption of tight intercellular junctions among epithelial cells under specific co...

    Authors: Long Yan, Feng Xu and Chao-liu Dai

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:203

    Content type: Review

    Published on:

  50. The pathophysiological roles and the therapeutic potentials of Myc family are reviewed in this article. The physiological functions and molecular machineries in stem cells, including embryonic stem (ES) cells ...

    Authors: Go J. Yoshida

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:173

    Content type: Review

    Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2018 37:285