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Reviews from Journal of Experimental & Clinical Cancer Research

Below is a summary of all reviews published in JECCR. 

Page 1 of 3

  1. Content type: Review

    The mechanism by which c-Myc exerts its oncogenic functions is not completely clear and different hypotheses are still under investigation. The knowledge of the capacity of c-Myc to bind exclusively E-box sequ...

    Authors: Matteo Caforio, Cristina Sorino, Stefano Iacovelli, Maurizio Fanciulli, Franco Locatelli and Valentina Folgiero

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:239

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  2. Content type: Review

    Non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer cases, and it is one of the leading causes of cancer death in both men and women worldwide due to diagnosis in the advanced stag...

    Authors: Hongmei Zheng, Yuting Zhan, Sile Liu, Junmi Lu, Jiadi Luo, Juan Feng and Songqing Fan

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:226

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  3. Content type: Review

    Phosphatase and tensin homologue (PTEN) triggers a battery of intracellular signaling pathways, especially PI3K/Akt, playing important roles in the pathogenesis of multiple diseases, such as cancer, neurodevel...

    Authors: Wang Li, Ting Zhang, Lianying Guo and Lin Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:223

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  4. Content type: Review

    Hepatocellular carcinoma (HCC) is a highly malignant disease with a poor prognosis and high mortality due to a low early diagnosis rate, resistance to systemic treatments and progression to late-stage liver di...

    Authors: Jie Li, Xu Han, Xiaona Yu, Zongzhen Xu, Guangsheng Yang, Bingqi Liu and Peng Xiu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:213

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  5. Content type: Review

    Circular RNAs (circRNAs) are a type of noncoding RNAs with a closed loop structure. With the development of high-throughput sequencing, massive circRNAs have been discovered in tumorous tissues. Emerging evide...

    Authors: Xuehui Wang and Lin Fang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:206

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  6. Content type: Review

    Epithelial-to-mesenchymal transition (EMT) is a complex process involving multiple genes, steps and stages. It refers to the disruption of tight intercellular junctions among epithelial cells under specific co...

    Authors: Long Yan, Feng Xu and Chao-liu Dai

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:203

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  8. Content type: Review

    Biomarkers are an integral part of cancer management due to their use in risk assessment, screening, differential diagnosis, prognosis, prediction of response to treatment, and monitoring progress of disease. ...

    Authors: Michelle H. Townsend, Gajendra Shrestha, Richard A. Robison and Kim L. O’Neill

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:163

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  9. Content type: Correction

    In the publication of this article [1], there is an error in the Figure caption of Figs. 2, 3 and 4. This has now been included in this correction. The authors declare that these corrections do not change the ...

    Authors: Mei Yi, Junjun Li, Shengnan Chen, Jing Cai, Yuanyuan Ban, Qian Peng, Ying Zhou, Zhaoyang Zeng, Shuping Peng, Xiaoling Li, Wei Xiong, Guiyuan Li and Bo Xiang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:155

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    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:118

  10. Content type: Review

    The natural history of mantle cell lymphoma (MCL) is a continuous process with the vicious cycle of remission and recurrence. Because MCL cells are most vulnerable before their exposure to therapeutic agents, ...

    Authors: Haige Ye, Aakash Desai, Shengjian Huang, Dayoung Jung, Richard Champlin, Dongfeng Zeng, Fangfang Yan, Krystle Nomie, Jorge Romaguera, Makhdum Ahmed and Michael L. Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:150

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  11. Content type: Review

    The immune system is composed of immune as well as non-immune cells. As this system is a well-established component of human papillomavirus- (HPV)-related carcinogenesis, high risk human papillomavirus (hrHPV)...

    Authors: Marconi Rego Barros Jr, Cristiane Moutinho Lagos de Melo, Maria Luiza Carneiro Moura Gonçalves Rego Barros, Rita de Cássia Pereira de Lima, Antonio Carlos de Freitas and Aldo Venuti

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:137

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  12. Content type: Review

    Oxidative stress is related to ageing and degenerative diseases, including cancer. However, a moderate amount of reactive oxygen species (ROS) is required for the regulation of cellular signalling and gene exp...

    Authors: Rodrigo Prieto-Bermejo, Marta Romo-González, Alejandro Pérez-Fernández, Carla Ijurko and Ángel Hernández-Hernández

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:125

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  13. Content type: Review

    Long non-coding RNAs (lncRNAs) refer to functional cellular RNAs molecules longer than 200 nucleotides in length. Unlike microRNAs, which have been widely studied, little is known about the enigmatic role of l...

    Authors: Lei Zhan, Jun Li and Bing Wei

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:120

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  14. Content type: Review

    Oncogenes derived from the neurotrophin receptor tropomyosin-related kinase TrkA act as drivers in sub-populations of a wide-range of human cancers. This, combined with a recent report that both adult and chil...

    Authors: Antonietta Rosella Farina, Lucia Cappabianca, Pierdomenico Ruggeri, Luciana Gneo, Cristina Pellegrini, Maria-Concetta Fargnoli and Andrew Reay Mackay

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:119

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  15. Content type: Review

    Cancer stem cells (CSCs) or tumor-initiating cells (TICs) represent a small population of cancer cells with self-renewal and tumor-initiating properties. Unlike the bulk of tumor cells, CSCs or TICs are refrac...

    Authors: Mei Yi, Junjun Li, Shengnan Chen, Jing Cai, Yuanyuan Ban, Qian Peng, Ying Zhou, Zhaoyang Zeng, Shuping Peng, Xiaoling Li, Wei Xiong, Guiyuan Li and Bo Xiang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:118

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    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2018 37:155

  16. Content type: Review

    Immune checkpoints include stimulatory and inhibitory checkpoint molecules. In recent years, inhibitory checkpoints, including cytotoxic T lymphocyte–associated antigen 4 (CTLA-4), programmed cell death protei...

    Authors: Feng Xu, Tianqiang Jin, Yuwen Zhu and Chaoliu Dai

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:110

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  17. Content type: Review

    Transfer RNAs (tRNAs), traditionally considered to participate in protein translation, were interspersed in the entire genome. Recent studies suggested that dysregulation was observed in not only tRNAs, but al...

    Authors: Shi-qiong Huang, Bao Sun, Zong-ping Xiong, Yan Shu, Hong-hao Zhou, Wei Zhang, Jing Xiong and Qing Li

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:101

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  19. Content type: Review

    Radioresistance is a major factor leading to the failure of radiotherapy and poor prognosis in tumor patients. Following the application of radiotherapy, the activity of various metabolic pathways considerably...

    Authors: Le Tang, Fang Wei, Yingfen Wu, Yi He, Lei Shi, Fang Xiong, Zhaojian Gong, Can Guo, Xiayu Li, Hao Deng, Ke Cao, Ming Zhou, Bo Xiang, Xiaoling Li, Yong Li, Guiyuan Li…

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:87

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  20. Content type: Review

    In the advent of Immune Checkpoint inhibitors (ICI) and of CAR-T adoptive T-cells, the new frontier in Oncology is Cancer Immunotherapy because of its ability to provide long term clinical benefit in metastati...

    Authors: Luigi Aurisicchio, Matteo Pallocca, Gennaro Ciliberto and Fabio Palombo

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:86

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  21. Content type: Review

    The epidermal growth factor receptor (EGFR) plays important roles in cell survival, growth, differentiation, and tumorigenesis. Dysregulation of the EGFR is a common mechanism in cancer progression especially ...

    Authors: Meng-Shih Weng, Jer-Hwa Chang, Wen-Yueh Hung, Yi-Chieh Yang and Ming-Hsien Chien

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:61

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  22. Content type: Review

    With cancer stem cells (CSCs) became the research hotspot, emerging studies attempt to reveal the functions of these special subsets in tumorigenesis. Although various approaches have been used in CSCs researc...

    Authors: Y. T. Luo, J. Cheng, X. Feng, S. J. He, Y. W. Wang and Q. Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:38

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  23. Content type: Review

    Current treatment for acute myeloid leukemia (AML) is less than optimal, but increased understanding of disease pathobiology and genomics has led to clinical investigation of novel targeted therapies and ratio...

    Authors: Silvia Boffo, Angela Damato, Luigi Alfano and Antonio Giordano

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:36

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  25. Content type: Review

    Since Salinomycin (Sal) emerged its ability to target breast cancer stem cells in 2009, numerous experiments have been carried out to test Sal’s anticancer effects. What deserve to be mentioned is that Sal can...

    Authors: Jiang Jiang, Hailong Li, Eskandar Qaed, Jing Zhang, Yushu Song, Rong Wu, Xinmiao Bu, Qinyan Wang and Zeyao Tang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:26

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  26. Content type: Review

    Antibody-Drug Conjugates (ADCs) are a class of cancer therapeutics that combines antigen specificity and potent cytotoxicity in a single molecule as they are comprised of an engineered antibody linked chemical...

    Authors: Cécile Chalouni and Sophia Doll

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:20

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  27. Content type: Review

    Cancer remains as one of the leading cause of death worldwide. The development of cancer involves an intricate process, wherein many identified and unidentified factors play a role. Although most studies have ...

    Authors: Nyanbol Kuol, Lily Stojanovska, Vasso Apostolopoulos and Kulmira Nurgali

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:5

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  28. Content type: Review

    Osteosarcoma (OS) is the most common primary malignant tumor of bone, which preferentially develops lung metastasis. Although standard chemotherapy has significantly improved long-term survival over the past f...

    Authors: Angela De Luca, Lavinia Raimondi, Francesca Salamanna, Valeria Carina, Viviana Costa, Daniele Bellavia, Riccardo Alessandro, Milena Fini and Gianluca Giavaresi

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:2

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  29. Content type: Review

    Telomeres are specialized nucleoprotein structures responsible for protecting chromosome ends in order to prevent the loss of genomic information. Telomere maintenance is required for achieving immortality by ...

    Authors: Luca Pompili, Carlo Leonetti, Annamaria Biroccio and Erica Salvati

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:189

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  30. Content type: Review

    Mantle cell lymphoma (MCL) is an aggressive disease, with poor prognosis and a limited survival. However, some patients with indolent MCL can survive beyond 7~10 years. These patients remain largely asymptomat...

    Authors: Haige Ye, Aakash Desai, Dongfeng Zeng, Krystle Nomie, Jorge Romaguera, Makhdum Ahmed and Michael L. Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:185

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  31. Content type: Review

    Glioblastoma Multiforme is the deadliest type of brain tumor and is characterized by very poor prognosis with a limited overall survival. Current optimal therapeutic approach has essentially remained unchanged...

    Authors: Claudia Abbruzzese, Silvia Matteoni, Michele Signore, Luca Cardone, Kavindra Nath, Jerry D. Glickson and Marco G. Paggi

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:169

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  32. Content type: Review

    CircRNAs are a class of RNA molecules that structurally form closed loops. CircRNAs are abundant in eukaryotic transcripts and show certain levels of tissue and cell specificity. CircRNAs have been suggested t...

    Authors: Yu Zhang, Wei Liang, Peng Zhang, Jingyan Chen, Hui Qian, Xu Zhang and Wenrong Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:152

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  33. Content type: Review

    The increasing use of genomics to define the pattern of actionable mutations and to test and validate new therapies for individual cancer patients, and the growing application of liquid biopsy to dynamically t...

    Authors: Nicola Silvestris, Gennaro Ciliberto, Paolo De Paoli, Giovanni Apolone, Maria Luisa Lavitrano, Marco A. Pierotti and Giorgio Stanta

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:128

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  34. Content type: Review

    Elucidation of mechanisms regulating bone metastasis has progressed significantly in recent years and this has translated to many new therapeutic options for patients with bone metastatic cancers. However, the...

    Authors: Andrew S. Gdowski, Amalendu Ranjan and Jamboor K. Vishwanatha

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:108

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  36. Content type: Review

    Worldwide breast cancer is the most common cancer in women. For many years clinicians and the researchers are examining and exploring various therapeutic modalities for breast cancer. Yet the disease has remai...

    Authors: Urmila Banik, Subramani Parasuraman, Arun Kumar Adhikary and Nor Hayati Othman

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:98

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  37. Content type: Review

    CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a prokaryotic adaptable immune mechanism used by many bacteria and archaea to protect themselves from foreign nucleic acids. This complex s...

    Authors: A. Biagioni, A. Chillà, E. Andreucci, A. Laurenzana, F. Margheri, S. Peppicelli, M. Del Rosso and G. Fibbi

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:80

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  38. Content type: Review

    The immune response is a key factor in the fight against HPV infection and related cancers, and thus, HPV is able to promote immune evasion through the expression of oncogenes. In particular, the E5 oncogene i...

    Authors: Antonio Carlos de Freitas, Talita Helena Araújo de Oliveira, Marconi Rego Barros Jr. and Aldo Venuti

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:71

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  39. Content type: Review

    Multiple myeloma (MM) is a clonal plasma-cell neoplastic disorder arising from an indolent premalignant disease known as monoclonal gammopathy of undetermined significance (MGUS). MM is a biologically complex ...

    Authors: Anna Shvartsur, Kevin B. Givechian, Hermes Garban and Benjamin Bonavida

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:62

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  40. Content type: Review

    Deptor is an important protein that belongs to the mTORC1 and mTORC2 complexes, able to interact with mTOR and to inhibit its kinase activity. As a natural mTOR inhibitor, Deptor is involved in several molecul...

    Authors: Valeria Catena and Maurizio Fanciulli

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:12

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  41. Content type: Review

    Identifying appropriate preclinical cancer models remains a major challenge in increasing the efficiency of drug development. A potential strategy to improve patient outcomes could be selecting the ‘right’ tre...

    Authors: Luca Pompili, Manuela Porru, Carla Caruso, Annamaria Biroccio and Carlo Leonetti

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:189

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  42. Content type: Review

    The mammalian sirtuin family has attracted tremendous attention over the past few years as stress adaptors and post-translational modifier. They have involved in diverse cellular processes including DNA repair...

    Authors: Zhen Mei, Xian Zhang, Jiarong Yi, Junjie Huang, Jian He and Yongguang Tao

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:182

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  43. Content type: Review

    DNA damage response (DDR) defects imply genomic instability and favor tumor progression but make the cells vulnerable to the pharmacological inhibition of the DNA repairing enzymes. Targeting cellular proteins...

    Authors: Aniello Cerrato, Francesco Morra and Angela Celetti

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:179

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  44. Content type: Review

    Epigenetic silencing of tumor suppressor genes (TSGs) through DNA methylation and histone changes is a main hallmark of cancer. Ubiquitin-like with PHD and RING Finger domains 1 (UHRF1) is a potent oncogene overe...

    Authors: Mahmoud Alhosin, Ziad Omran, Mazin A. Zamzami, Abdulrahman L. Al-Malki, Hani Choudhry, Marc Mousli and Christian Bronner

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:174

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  45. Content type: Review

    Among several types of tumor, lung cancer is considered one of the most fatal and still the main cause of cancer-related deaths. Although chemotherapeutic agents can improve survival and quality of life compar...

    Authors: Mohanad Aldarouish and Cailian Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:157

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  46. Content type: Review

    Exosomes are nanoscale extracellular membrane vesicles that are created by the fusion of an intracellular multivesicular body with the cell membrane. They are widely distributed in serum, urine, saliva and oth...

    Authors: Wenting Xu, Zhen Yang and Nonghua Lu

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:156

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  47. Content type: Review

    Major currently used anticancer therapeutics either directly damage DNA or target and upset basic cell division mechanisms like DNA replication and chromosome segregation. These insults elicit activation of ce...

    Authors: Roberta Visconti, Rosa Della Monica and Domenico Grieco

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:153

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  48. Content type: Review

    The advent of targeted therapeutics in human cancer has begun to find novel druggable targets and, in this context, the endothelin-1 receptor (ET-1R), namely ETA receptor (ETAR) and ETB receptor, among the GPCR f...

    Authors: Laura Rosanò and Anna Bagnato

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:121

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  49. Content type: Review

    Recent progress in the Nerve Growth Factor (NGF) research has shown that this factor acts not only outside its classical domain of the peripheral and central nervous system, but also on non-neuronal and cancer...

    Authors: Luigi Aloe, Maria Luisa Rocco, Bijorn Omar Balzamino and Alessandra Micera

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:116

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  50. Content type: Review

    The discovery of human epidermal growth factor receptor 2 (HER2) and its role in the biology of breast cancer and the subsequent development of HER2-targeted therapies, have dramatically improved clinical outc...

    Authors: Alessandra Fabi, Paola Malaguti, Sabrina Vari and Francesco Cognetti

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:104

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