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Pluripotency and mechanisms of somatic cell reprogramming

The remarkable ability of embryonic stem cells to differentiate into all cell types that compose a body has experienced dramatic progress in recent years, but still remains poorly understood. Clarifying further how this is regulated will facilitate improving methods for isolation and expansion, as well as their faithful directed differentiation into cell lineages of interest.

Somatic reprogramming to pluripotency has been a truly groundbreaking discovery, yet even after nearly a decade of intense research the true underlying mechanisms behind this remarkable process remain frustratingly unclear. This series, published in Cell Regeneration, aims to address those questions. 

The articles in the series have undergone the journal’s standard peer-review process. The Editors for this series declare no competing interests.