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PSMA-PET for individualized radiation therapy of prostate cancer

New Content Item (4)Guest Edited by Dr Pirus Ghadjar 

The advent of prostate specific membrane antigen (PSMA) positron emission tomography (PET) imaging has revolutionized radiation therapy of prostate cancer.  Current radiation therapy treatment schedules for prostate cancer have been established by randomized trials using statistical risk calculations, nomograms and conventional imaging for patient characterization and treatment.  PSMA-PET bears the promise of delivering individually tailored radiation therapy for prostate cancer.  It can already be regarded as ‘practice changing’ for radiation therapy of prostate cancer, especially concerning detection and treatment of lymph node metastases, local recurrences after prior therapies and oligometastases.  However any randomized or long-term clinical data after PSMA guided radiation therapy for prostate cancer is naturally missing.  Moreover, radio-ligand therapy (RLT) is a new treatment option for metastatic castration-resistant prostate cancer patients.

The aim of this thematic series published in Radiation Oncology is to collect and present the current knowledge and limitations of PSMA-PET based radiation therapy.

  1. Content type: Research

    To determine the potential role of 68Ga-PSMA positron emission tomography/computed tomography (PET/CT) in radiotherapy (RT) planning for prostate cancer (PCa).

    Authors: Nina-Sophie Schmidt-Hegemann, Wolfgang Peter Fendler, Alexander Buchner, Christian Stief, Paul Rogowski, Maximilian Niyazi, Chukwuka Eze, Minglun Li, Peter Bartenstein, Claus Belka and Ute Ganswindt

    Citation: Radiation Oncology 2017 12:176

    Published on:

  2. Content type: Research

    By the use of PSMA positron emission tomography (PET) detection of prostate cancer lesions with a high sensitivity and specificity combined with a favorable lesion to background contrast is feasible. Therefore...

    Authors: Sebastian Zschaeck, Peter Wust, Marcus Beck, Waldemar Wlodarczyk, David Kaul, Julian Rogasch, Volker Budach, Christian Furth and Pirus Ghadjar

    Citation: Radiation Oncology 2017 12:140

    Published on: