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Parkinson's Disease - a series of reviews

New Content ItemThis series, guest-edited by Mark Cookson and Ted Dawson, collates reviews surrounding the topic of Parkinson's Disease to provide a comprehensive oversight of recent advances and viewpoints across the field.

All submissions have been subject to Molecular Neurodegeneration's standard peer review process, and articles will be added to this series throughout the coming year. 

  1. Parkinson's disease is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons of the nigrostriatal pathway and the formation of neuronal inclusions known as Lewy bodies. Chro...

    Authors: Karim Belarbi, Elodie Cuvelier, Marie-Amandine Bonte, Mazarine Desplanque, Bernard Gressier, David Devos and Marie-Christine Chartier-Harlin

    Citation: Molecular Neurodegeneration 2020 15:59

    Content type: Review

    Published on:

  2. That certain cell types in the central nervous system are more likely to undergo neurodegeneration in Parkinson’s disease is a widely appreciated but poorly understood phenomenon. Many vulnerable subpopulation...

    Authors: Preston Ge, Valina L. Dawson and Ted M. Dawson

    Citation: Molecular Neurodegeneration 2020 15:20

    Content type: Review

    Published on:

  3. Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central to the aetiology of Parkinson’s disease, a considerable amount of work has gone into uncovering its basic cellula...

    Authors: Daniel C. Berwick, George R. Heaton, Sonia Azeggagh and Kirsten Harvey

    Citation: Molecular Neurodegeneration 2019 14:49

    Content type: Review

    Published on:

  4. Mutations in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, are among the most common known genetic risk factors for the development of Parkinson disease and related synucleinopathies. A great d...

    Authors: Jenny Do, Cindy McKinney, Pankaj Sharma and Ellen Sidransky

    Citation: Molecular Neurodegeneration 2019 14:36

    Content type: Review

    Published on:

  5. A full understanding of Parkinson’s Disease etiopathogenesis and of the causes of the preferential vulnerability of nigrostriatal dopaminergic neurons is still an unsolved puzzle. A multiple-hit hypothesis has...

    Authors: Anna Masato, Nicoletta Plotegher, Daniela Boassa and Luigi Bubacco

    Citation: Molecular Neurodegeneration 2019 14:35

    Content type: Review

    Published on:

  6. An emerging picture suggests that glial cells’ loss of beneficial roles or gain of toxic functions can contribute to neurodegenerative conditions. Among glial cells, microglia and astrocytes have been shown to...

    Authors: Marie-Eve Tremblay, Mark R. Cookson and Laura Civiero

    Citation: Molecular Neurodegeneration 2019 14:16

    Content type: Review

    Published on:

  7. Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes with normal life and daily activities. Neuropathologically, DLB is charac...

    Authors: Tiago Fleming Outeiro, David J. Koss, Daniel Erskine, Lauren Walker, Marzena Kurzawa-Akanbi, David Burn, Paul Donaghy, Christopher Morris, John-Paul Taylor, Alan Thomas, Johannes Attems and Ian McKeith

    Citation: Molecular Neurodegeneration 2019 14:5

    Content type: Review

    Published on:

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