JEMS Open Symposia 2017 & 2018: Challenges of Young Scientists

Evaluation of the novel liver micronucleus assay using formalin-fixed tissues

The repeated-dose liver micronucleus (RDLMN) assay is an effective and important in vivo test for detecting genotoxic compounds, particularly for those that require metabolic activation to show genotoxicity. I...

Authors: Shuichi Hamada, Miyuki Shigano, Satoru Kawakami, Maya Ueda, Hajime Sui, Katsuya Yamada, Soichiro Hagio, Ayaka Momonami, Akihisa Maeda, Yukari Terashima, Wakako Ohyama, Takeshi Morita and Makoto Hayashi

Citation: Genes and Environment 2019 41:13

Content type: Research

Published on: 9 May 2019
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Development of novel and safer anti-breast cancer agents, SS1020 and SS5020, based on a fundamental carcinogenic research

Tamoxifen (TAM) has been prescribed worldwide to patients with and women at high-risk of breast cancer. However, long-term use of TAM increases the incidence of endometrial cancer. The carcinogenic mechanisms ...

Authors: Yoshinori Okamoto and Shinya Shibutani

Citation: Genes and Environment 2019 41:9

Content type: Review

Published on: 28 March 2019
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Importance of finding the bona fide target of the Fanconi anemia pathway

Fanconi anemia (FA) is a rare genetic disease characterized by the deficiency of the cellular response and repair pathway for DNA interstrand crosslink (ICL) damage. Although recent studies have revealed the d...

Authors: Wataru Sakai and Kaoru Sugasawa

Citation: Genes and Environment 2019 41:6

Content type: Review

Published on: 6 March 2019
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Current perspectives on mechanisms of ribonucleotide incorporation and processing in mammalian DNA

Ribonucleotides, which are RNA precursors, are often incorporated into DNA during replication. Although embedded ribonucleotides in the genome are efficiently removed by canonical ribonucleotide excision repai...

Authors: Akira Sassa, Manabu Yasui and Masamitsu Honma

Citation: Genes and Environment 2019 41:3

Content type: Review

Published on: 25 January 2019
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Challenges of young scientists at the cutting-edge of genotoxicity research: the open symposium of the Japanese Environmental Mutagen Society (JEMS), 2018

The Open Symposium of the Japanese Environmental Mutagen Society (JEMS) entitled “Challenges of Young Scientists at the Cutting-edge of Genotoxicity Research” was held in the Main Conference Room of the Founda...

Authors: Manabu Yasui, Shigeharu Muto and Akira Sassa

Citation: Genes and Environment 2018 40:22

Content type: Meeting report

Published on: 2 November 2018
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Advantages of evaluating γH2AX induction in non-clinical drug development

γH2AX, the phosphorylated form of a histone variant H2AX at Ser 139, is already widely used as a biomarker to research the fundamental biology of DNA damage and repair and to assess the risk of environmental c...

Authors: Shigeki Motoyama, Akira Takeiri, Kenji Tanaka, Asako Harada, Kaori Matsuzaki, Junko Taketo, Saori Matsuo, Etsuko Fujii and Masayuki Mishima

Citation: Genes and Environment 2018 40:10

Content type: Review

Published on: 14 May 2018
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Necessity for retrospective evaluation of past-positive chemicals in in vitro chromosomal aberration tests using recommended cytotoxicity indices

We have demonstrated that retrospective evaluation of existing data of in vitro chromosomal aberration test using the new cytotoxicity indices RICC (relative increase in cell count) or RPD (relative population...

Authors: Hiroshi Honda, Yurika Fujita, Toshio Kasamatsu, Anne Fuchs, Rolf Fautz and Osamu Morita

Citation: Genes and Environment 2018 40:2

Content type: Letter to the Editor

Published on: 10 January 2018
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Research on environmental mutagenesis from young scientists – the open symposium of the Japanese Environmental Mutagen Society (JEMS) in 2017

The open symposium of the Japanese Environmental Mutagen Society (JEMS) titled, “Research on Environmental Mutagenesis from Young Scientists,” was held at Kokusai Kenkyu Koryu Kaikan, the Foundation for Promot...

Authors: Kenichi Masumura and Shuichi Masuda

Citation: Genes and Environment 2017 39:26

Content type: Meeting report

Published on: 1 November 2017
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