Edited by Satoshi Gando.
Sepsis, systemic inflammatory responses to infection, is one of the leading causes of death worldwide. Inflammatory cytokines activate leukocytes and deteriorate endothelial cell function. Inflammatory cytokines advance disseminated intravascular coagulation (DIC), leading to microvascular thrombosis. Both tissue dysoxia caused by endothelial dysfunction and tissue hypoxia caused by microvascular thrombosis are the two main mechanisms of multiple organ dysfunction in sepsis.
In this thematic series, published in Journal of Intensive Care, the authors review the pathophysiology of organ dysfunction in sepsis. The role of two main pathomechanisms of organ dysfunction, DIC and endothelial cell dysfunction, are also discussed.
This series of articles has not been sponsored. All articles have undergone the journal’s standard peer review process overseen by the Editor in Chief. The Editor in Chief declares no competing interests.