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Organ dysfunction in sepsis

Edited by Satoshi Gando.

Sepsis, systemic inflammatory responses to infection, is one of the leading causes of death worldwide. Inflammatory cytokines activate leukocytes and deteriorate endothelial cell function. Inflammatory cytokines advance disseminated intravascular coagulation (DIC), leading to microvascular thrombosis. Both tissue dysoxia caused by endothelial dysfunction and tissue hypoxia caused by microvascular thrombosis are the two main mechanisms of multiple organ dysfunction in sepsis.

In this thematic series, published in Journal of Intensive Care, the authors review the pathophysiology of organ dysfunction in sepsis. The role of two main pathomechanisms of organ dysfunction, DIC and endothelial cell dysfunction, are also discussed.

This series of articles has not been sponsored. All articles have undergone the journal’s standard peer review process overseen by the Editor in Chief. The Editor in Chief declares no competing interests.

  1. Research

    Usefulness of plasminogen activator inhibitor-1 as a predictive marker of mortality in sepsis

    Sepsis is one of the most significant causes of mortality in intensive care units. It indicates crosstalk between inflammation and coagulation. In this study, we aimed to identify prognostic markers among seps...

    Kota Hoshino, Taisuke Kitamura, Yoshihiko Nakamura, Yuhei Irie, Norihiko Matsumoto, Yasumasa Kawano and Hiroyasu Ishikura

    Journal of Intensive Care 2017 5:42

    Published on: 11 July 2017

  2. Research

    Association between recurrence of acute kidney injury and mortality in intensive care unit patients with severe sepsis

    Acute kidney injury (AKI) occurs in more than half critically ill patients admitted in intensive care units (ICU) and increases the mortality risk. The main cause of AKI in ICU is sepsis. AKI severity and othe...

    Emilio Rodrigo, Borja Suberviola, Miguel Santibáñez, Lara Belmar, Álvaro Castellanos, Milagros Heras, Juan Carlos Rodríguez-Borregán, Angel Luis Martín de Francisco and Claudio Ronco

    Journal of Intensive Care 2017 5:28

    Published on: 22 May 2017

  3. Commentary

    Are you Ernest Shackleton, the polar explorer? Refining the criteria for delirium and brain dysfunction in sepsis

    The Third International Consensus Definitions for Sepsis and Septic Shock has recently defined sepsis as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Organ dysfunct...

    Frank Anthony Rasulo, Giuseppe Bellelli, Eugene Wesley Ely, Alessandro Morandi, Pratik Pandharipande and Nicola Latronico

    Journal of Intensive Care 2017 5:23

    Published on: 7 March 2017

  4. Review

    Sepsis-induced cardiac dysfunction and β-adrenergic blockade therapy for sepsis

    Despite recent advances in medical care, mortality due to sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, remains high. Fluid resuscitation and vasopr...

    Takeshi Suzuki, Yuta Suzuki, Jun Okuda, Takuya Kurazumi, Tomohiro Suhara, Tomomi Ueda, Hiromasa Nagata and Hiroshi Morisaki

    Journal of Intensive Care 2017 5:22

    Published on: 3 March 2017

  5. Review

    Sepsis-induced myocardial dysfunction: pathophysiology and management

    Sepsis is aggravated by an inappropriate immune response to invading microorganisms, which occasionally leads to multiple organ failure. Several lines of evidence suggest that the ventricular myocardium is dep...

    Yasuyuki Kakihana, Takashi Ito, Mayumi Nakahara, Keiji Yamaguchi and Tomotsugu Yasuda

    Journal of Intensive Care 2016 4:22

    Published on: 23 March 2016

  6. Review

    A clinical perspective of sepsis-associated delirium

    The term sepsis-associated encephalopathy (SAE) has been applied to animal models, postmortem studies in patients, and severe cases of sepsis. SAE is considered to include all types of brain dysfunction, inclu...

    Ryosuke Tsuruta and Yasutaka Oda

    Journal of Intensive Care 2016 4:18

    Published on: 23 March 2016

  7. Review

    Sepsis and disseminated intravascular coagulation

    Sepsis is frequently complicated by coagulopathy and, in about 35 % of severe cases, by disseminated intravascular coagulation (DIC). In Japan, aggressive treatment of septic DIC is encouraged using antithromb...

    Kohji Okamoto, Toshihisa Tamura and Yusuke Sawatsubashi

    Journal of Intensive Care 2016 4:23

    Published on: 23 March 2016

  8. Review

    Role of kidney injury in sepsis

    Kidney injury, including acute kidney injury (AKI) and chronic kidney disease (CKD), has become very common in critically ill patients treated in ICUs. Many epidemiological studies have revealed significant as...

    Kent Doi

    Journal of Intensive Care 2016 4:17

    Published on: 23 March 2016

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