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Onchocerciasis-associated epilepsy

Guest edited by Robert Colebunders, Robert Ryder, Patrick Suykerbuyk and Richard Idro

An article collection in Infectious Diseases of Poverty.

Infectious Diseases of PovertyNodding syndrome is a devastating epileptic syndrome appearing in previously healthy children between the ages of 5 and 18 years. The syndrome is characterized by head-nodding, an atonic seizure, and is often followed by tonic-clonic seizures, declining cognitive and motor function, psychiatric problems, stunting growth, physical deformities and early death. Until recently the cause of the syndrome was unknown. Therefore, no strategy for prevention and cure was possible. Recent studies have shown that nodding syndrome is only one of several clinical presentations of onchocerciasis-associated epilepsy (OAE) and that this form of epilepsy is present in all regions where onchocerciasis (river blindness) is poorly controlled. This series contains original papers about OAE research done in Uganda, Tanzania, Cameroon and the Democratic Republic of the Congo and review papers related to onchocerciasis and epilepsy.

  1. Content type: Scoping Review

    Onchocerciasis-endemic regions are known to have a high epilepsy prevalence. Limited resources in these areas and poor access to healthcare by persons with epilepsy (PWE) result in a wide anti-epileptic treatment...

    Authors: Joseph Nelson Siewe Fodjo, Marieke C. J. Dekker, Richard Idro, Michel Ndahura Mandro, Pierre-Marie Preux, Alfred K. Njamnshi and Robert Colebunders

    Citation: Infectious Diseases of Poverty 2019 8:11

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  2. Content type: Research Article

    High epilepsy prevalence and incidence have been reported in areas with high onchocerciasis transmission. Recent findings suggest that proper community-directed treatment with ivermectin (CDTI) is potentially ...

    Authors: Joseph N. F. Siewe, Chinyere N. Ukaga, Ernest O. Nwazor, Murphy O. Nwoke, Modebelu C. Nwokeji, Blessing C. Onuoha, Simon O. Nwanjor, Joel Okeke, Kate Osahor, Lilian Chimechefulam, Ann I. Ogomaka, Augustine A. Amaechi, Chika I. Ezenwa, Monika N. Ezike, Chidimma Ikpeama, Ogechi Nwachukwu…

    Citation: Infectious Diseases of Poverty 2019 8:8

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  3. Content type: Research Article

    A recent study in the Logo and Rethy health zones in the Ituri Province in the Democratic Republic of Congo (DRC) reported that the majority of the persons with epilepsy (PWE) had not been treated with anti-ep...

    Authors: Housseini Dolo, Michel Mandro, Deogratias Wonya’Rossi, Francoise Ngave, Jessica Fraeyman, Joseph N. Siewe, Patrick Suykerbuyk and Robert Colebunders

    Citation: Infectious Diseases of Poverty 2018 7:115

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  4. Content type: Study Protocol

    Nodding syndrome (NS) is a devastating epileptic illness of unknown aetiology mainly affecting children 5–15 years of age. Head nodding distinguishes NS from other forms of epilepsy. Other manifestations of th...

    Authors: Gasim Abd-Elfarag, Makoy Yibi Logora, Jane Y. Carter, Morrish Ojok, Jackson Songok, Sonia Menon, Ferdinand Wit, Richard Lako and Robert Colebunders

    Citation: Infectious Diseases of Poverty 2018 7:112

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  5. Content type: Case study

    A high prevalence of epilepsy has been observed in onchocerciasis endemic areas in the Democratic Republic of Congo (DRC). With this study we aimed to investigate whether Onchocerca volvulus infection is a risk f...

    Authors: Michel Mandro, Patrick Suykerbuyk, Floribert Tepage, Degratias Rossy, Francoise Ngave, Mirza Nazmul Hasan, An Hotterbeekx, Germain Mambandu, Jean Marie Kashama, Anne Laudisoit and Robert Colebunders

    Citation: Infectious Diseases of Poverty 2018 7:79

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  6. Content type: Scoping Review

    Since the 1990s, evidence has accumulated of an increased prevalence of epilepsy in onchocerciasis-endemic areas in Africa as compared to onchocerciasis-free areas. Although the causal relationship between onc...

    Authors: Natalie V. S. Vinkeles Melchers, Sarah Mollenkopf, Robert Colebunders, Michael Edlinger, Luc E. Coffeng, Julia Irani, Trésor Zola, Joseph N. Siewe, Sake J. de Vlas, Andrea S. Winkler and Wilma A. Stolk

    Citation: Infectious Diseases of Poverty 2018 7:101

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  7. Content type: Research Article

    Epilepsy is a neurological disorder with a multitude of underlying causes, which may include infection with Onchocerca volvulus, the parasitic worm that causes human onchocerciasis. A survey carried out in 1989 r...

    Authors: Bruno P. Mmbando, Patrick Suykerbuyk, Mohamed Mnacho, Advocatus Kakorozya, William Matuja, Adam Hendy, Helena Greter, Williams H. Makunde and Robert Colebunders

    Citation: Infectious Diseases of Poverty 2018 7:64

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  8. Content type: Editorial

    Recently, several epidemiological studies performed in Onchocerca volvulus-endemic regions have suggested that onchocerciasis-associated epilepsy (OAE) may constitute an important but neglected public health prob...

    Authors: Robert Colebunders, Michel Mandro, Alfred K. Njamnshi, Michel Boussinesq, An Hotterbeekx, Joseph Kamgno, Sarah O’Neill, Adrian Hopkins, Patrick Suykerbuyk, Maria-Gloria Basáñez, Rory J. Post, Belén Pedrique, Pierre-Marie Preux, Wilma A. Stolk, Thomas B. Nutman and Richard Idro

    Citation: Infectious Diseases of Poverty 2018 7:23

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