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Neuropathology and Neurodegeneration in the Retina

Guest Editors:
Associate Professor Pete Williams, PhD, Karolinska Institutet, Sweden
Professor Maya Koronyo-Hamaoui, PhD, Cedars-Sinai Medical Center, United States of America
Professor Joanne Matsubara, PhD, The University of British Columbia, Canada

Submission Status: Open   |   Submission Deadline: 30 June 2024

Acta Neuropathologica Communications is calling for submissions to our new Collection on "Neuropathology and Neurodegeneration in the Retina".

Image credit: James Tribble, Pete Williams, Karolinska Institutet

About the collection

Neurodegenerative disease accounts for a large and increasing health and economic burden worldwide. With an increasingly aged population this burden is set to increase. Ocular neurodegenerative diseases make up a large proportion of neurodegenerative diseases (e.g. glaucoma is the leading cause of irreversible blindness affecting >80 million people and diabetic retinopathy is a common complication of diabetes). 

Given its ease of imaging and accessibility, the retina is an accessible component of the central nervous system and its role in neurodegenerative diseases is being increasingly recognized. Early retinal phenotypes have been demonstrated in human patients and animal models of Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. In addition to understanding disease pathology and mechanisms, these phenotypes can also be utilized to identify biomarkers of disease and help stage brain pathology.

This Collection will highlight basic, translational, and clinical studies that address current research, problems, and knowledge gaps in retinal neurodegenerations in topics that include, but are not limited to:

- Retinal degenerations (e.g. retinitis pigmentosa, Stargardt’s disease)

- Optic neuropathies (e.g. glaucoma, Leber’s hereditary optic neuropathy, autosomal dominant optic atrophy)

- Retinal complications and neurodegenerations from systemic disease (e.g. diabetic retinopathy)

- Retinal phenotypes in neurodegenerative disease (e.g. Alzheimer’s disease, Parkinson’s disease)

  1. The microtubule-associated protein Tau is a key player in various neurodegenerative conditions, including Alzheimer's disease (AD) and Tauopathies, where its hyperphosphorylation disrupts neuronal microtubular...

    Authors: Kanishka Pushpitha Maha Thananthirige, Nitin Chitranshi, Devaraj Basavarajappa, Rashi Rajput, Mojdeh Abbasi, Viswanthram Palanivel, Veer Bala Gupta, Joao A. Paulo, Maya Koronyo-Hamaoui, Mehdi Mirzaei, Stuart L. Graham and Vivek Gupta
    Citation: Acta Neuropathologica Communications 2024 12:89
  2. Here, we test whether early visual and OCT rod energy-linked biomarkers indicating pathophysiology in nicotinamide nucleotide transhydrogenase (Nnt)-null 5xFAD mice also occur in Nnt-intact 5xFAD mice and whether...

    Authors: Bruce A. Berkowitz, Anuhya Paruchuri, Josh Stanek, Mura Abdul-Nabi, Robert H. Podolsky, Abner Heredia Bustos, Karen Lins Childers, Geoffrey G. Murphy, Katherine Stangis and Robin Roberts
    Citation: Acta Neuropathologica Communications 2024 12:85
  3. Neurons pose a particular challenge to degradative processes like autophagy due to their long and thin processes. Autophagic vesicles (AVs) are formed at the tip of the axon and transported back to the soma. T...

    Authors: Xiaoyue Luo, Jiong Zhang, Johan Tolö, Sebastian Kügler, Uwe Michel, Mathias Bähr and Jan Christoph Koch
    Citation: Acta Neuropathologica Communications 2024 12:82
  4. Neurodegenerative diseases have common underlying pathological mechanisms including progressive neuronal dysfunction, axonal and dendritic retraction, and mitochondrial dysfunction resulting in neuronal death....

    Authors: Anne Rombaut, Danica Jovancevic, Raymond Ching-Bong Wong, Alan Nicol, Rune Brautaset, David I. Finkelstein, Christine T. O. Nguyen, James R. Tribble and Pete A. Williams
    Citation: Acta Neuropathologica Communications 2024 12:79
  5. Activated microglia play an important role in driving photoreceptor degeneration-associated neuroinflammation in the retina. Controlling pro-inflammatory activation of microglia holds promise for mitigating th...

    Authors: Daijin Li, Jie Chang, Yujue Wang, Xiaoye Du, Jing Xu, Jingang Cui, Teng Zhang and Yu Chen
    Citation: Acta Neuropathologica Communications 2024 12:76
  6. The progressive and irreversible degeneration of retinal ganglion cells (RGCs) and their axons is the major characteristic of glaucoma, a leading cause of irreversible blindness worldwide. Nicotinamide adenine...

    Authors: Myungjin Kim, Jun Yong Kim, Won-Kyu Rhim, Gloria Cimaglia, Andrew Want, James E. Morgan, Pete A. Williams, Chun Gwon Park, Dong Keun Han and Seungsoo Rho
    Citation: Acta Neuropathologica Communications 2024 12:65
  7. Glaucoma leads to vision loss due to retinal ganglion cell death. Astrocyte reactivity contributes to neurodegeneration. Our recent study found that lipoxin B4 (LXB4), produced by retinal astrocytes, has direct n...

    Authors: Shruthi Karnam, Shubham Maurya, Elainna Ng, Amodini Choudhary, Arzin Thobani, John G Flanagan and Karsten Gronert
    Citation: Acta Neuropathologica Communications 2024 12:58
  8. Microglia-mediated neuroinflammatory responses are recognized as a predominant factor during high intraocular pressure (IOP)-induced retinal and optic nerve injury along with potential therapeutic targets for ...

    Authors: Shangli Ji, Yanfang Peng, Jian Liu, Pang Xu and Shibo Tang
    Citation: Acta Neuropathologica Communications 2024 12:44
  9. Leber’s hereditary optic neuropathy (LHON) is driven by mtDNA mutations affecting Complex I presenting as progressive retinal ganglion cell dysfunction usually in the absence of extra-ophthalmic symptoms. Ther...

    Authors: Amin Otmani, Gauti Jóhannesson, Rune Brautaset, James R. Tribble and Pete A. Williams
    Citation: Acta Neuropathologica Communications 2024 12:37
  10. Glaucoma is one of the leading causes of irreversible blindness worldwide and vision loss in the disease results from the deterioration of retinal ganglion cells (RGC) and their axons. Metabolic dysfunction of...

    Authors: Huilan Zeng, Jordan E. Mayberry, David Wadkins, Nathan Chen, Daniel W. Summers and Markus H. Kuehn
    Citation: Acta Neuropathologica Communications 2024 12:23
  11. Excitotoxicity from the impairment of glutamate uptake constitutes an important mechanism in neurodegenerative diseases such as Alzheimer’s, multiple sclerosis, and Parkinson's disease. Within the eye, excitot...

    Authors: Da Ma, Wenyu Deng, Zain Khera, Thajunnisa A. Sajitha, Xinlei Wang, Gadi Wollstein, Joel S. Schuman, Sieun Lee, Haolun Shi, Myeong Jin Ju, Joanne Matsubara, Mirza Faisal Beg, Marinko Sarunic, Rebecca M. Sappington and Kevin C. Chan
    Citation: Acta Neuropathologica Communications 2024 12:19
  12. Glaucoma, the second leading cause of irreversible blindness worldwide, is associated with age and sensitivity to intraocular pressure (IOP). We have shown that elevated IOP causes an early increase in levels ...

    Authors: Sarah Naguib, Jon R. Backstrom, Elisabeth Artis, Purnima Ghose, Amy Stahl, Rachael Hardin, Ameer A. Haider, John Ang, David J. Calkins and Tonia S. Rex
    Citation: Acta Neuropathologica Communications 2023 11:171
  13. Astrocytes are a major category of glial support cell in the central nervous system and play a variety of essential roles in both health and disease. As our understanding of the diverse functions of these cell...

    Authors: Paul F. Cullen, Arpan G. Mazumder, Daniel Sun and John G. Flanagan
    Citation: Acta Neuropathologica Communications 2023 11:154
  14. Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head trauma. Brain pathology in CTE is characterized by neuronal loss, gliosis, and a distinctive pattern of neu...

    Authors: Ragini Phansalkar, Vanessa S. Goodwill, Jeffrey J. Nirschl, Chiara De Lillo, Jihee Choi, Elizabeth Spurlock, David G. Coughlin, Donald Pizzo, Christina J. Sigurdson, Annie Hiniker, Victor E. Alvarez, Ann C. Mckee and Jonathan H. Lin
    Citation: Acta Neuropathologica Communications 2023 11:152
  15. Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in physiological range. Imbalances in metabolism and mitochondrial ...

    Authors: Alessio Canovai, James R. Tribble, Melissa Jöe, Daniela Y. Westerlund, Rosario Amato, Ian A. Trounce, Massimo Dal Monte and Pete A. Williams
    Citation: Acta Neuropathologica Communications 2023 11:146

Submission Guidelines

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Before submitting your manuscript, please ensure you have read our submission guidelines. Articles for this Collection should be submitted via Editorial Manager. During the submission process you will be asked whether you are submitting to a Collection, please select "Neuropathology and Neurodegeneration in the Retina" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests.