Guest Editors:
Pete Williams: Karolinska Institutet, Sweden
Maya Koronyo-Hamaoui: Cedars-Sinai Medical Center, USA
Joanne Matsubara: The University of British Columbia, Canada
Acta Neuropathologica Communications is calling for submissions to our new Collection on "Neuropathology and Neurodegeneration in the Retina".
Image credit: James Tribble, Pete Williams, Karolinska Institutet
Neurodegenerative disease accounts for a large and increasing health and economic burden worldwide. With an increasingly aged population this burden is set to increase. Ocular neurodegenerative diseases make up a large proportion of neurodegenerative diseases (e.g. glaucoma is the leading cause of irreversible blindness affecting >80 million people and diabetic retinopathy is a common complication of diabetes).
Given its ease of imaging and accessibility, the retina is an accessible component of the central nervous system and its role in neurodegenerative diseases is being increasingly recognized. Early retinal phenotypes have been demonstrated in human patients and animal models of Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. In addition to understanding disease pathology and mechanisms, these phenotypes can also be utilized to identify biomarkers of disease and help stage brain pathology.
This Collection will highlight basic, translational, and clinical studies that address current research, problems, and knowledge gaps in retinal neurodegenerations in topics that include, but are not limited to:
- Retinal degenerations (e.g. retinitis pigmentosa, Stargardt’s disease)
- Optic neuropathies (e.g. glaucoma, Leber’s hereditary optic neuropathy, autosomal dominant optic atrophy)
- Retinal complications and neurodegenerations from systemic disease (e.g. diabetic retinopathy)
- Retinal phenotypes in neurodegenerative disease (e.g. Alzheimer’s disease, Parkinson’s disease)
The progressive and irreversible degeneration of retinal ganglion cells (RGCs) and their axons is the major characteristic of glaucoma, a leading cause of irreversible blindness worldwide. Nicotinamide adenine...
Glaucoma leads to vision loss due to retinal ganglion cell death. Astrocyte reactivity contributes to neurodegeneration. Our recent study found that lipoxin B4 (LXB4), produced by retinal astrocytes, has direct n...
Microglia-mediated neuroinflammatory responses are recognized as a predominant factor during high intraocular pressure (IOP)-induced retinal and optic nerve injury along with potential therapeutic targets for ...
Leber’s hereditary optic neuropathy (LHON) is driven by mtDNA mutations affecting Complex I presenting as progressive retinal ganglion cell dysfunction usually in the absence of extra-ophthalmic symptoms. Ther...
Glaucoma is one of the leading causes of irreversible blindness worldwide and vision loss in the disease results from the deterioration of retinal ganglion cells (RGC) and their axons. Metabolic dysfunction of...
Excitotoxicity from the impairment of glutamate uptake constitutes an important mechanism in neurodegenerative diseases such as Alzheimer’s, multiple sclerosis, and Parkinson's disease. Within the eye, excitot...
Glaucoma, the second leading cause of irreversible blindness worldwide, is associated with age and sensitivity to intraocular pressure (IOP). We have shown that elevated IOP causes an early increase in levels ...
Astrocytes are a major category of glial support cell in the central nervous system and play a variety of essential roles in both health and disease. As our understanding of the diverse functions of these cell...
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head trauma. Brain pathology in CTE is characterized by neuronal loss, gliosis, and a distinctive pattern of neu...
Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in physiological range. Imbalances in metabolism and mitochondrial ...
Before submitting your manuscript, please ensure you have read our submission guidelines. Articles for this Collection should be submitted via Editorial Manager. During the submission process you will be asked whether you are submitting to a Collection, please select "Neuropathology and Neurodegeneration in the Retina" from the dropdown menu.
Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.
The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests.