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Nutrition and metabolism in health and disease

Lifestyle-related diseases such as diabetes and cancer represent one of the greatest challenges to health and wellbeing in the developed world. These complex disorders are difficult to treat effectively, and are increasingly prevalent as sedentary lifestyles and calorie-rich, nutrient-poor diets cause an obesity crisis throughout the developed world. The Metabolism, Diet and Disease conference aims to show how basic research on the biochemistry, cell biology and genetics of metabolism can address the major health problems of cancer, obesity, diabetes and insulin resistance, and can explain ageing and longevity.

In addition, the conference provides a forum to explore the role of lifestyle factors such as diet in disease. This cross-journal collection builds on these aims by using research from across the fields of nutrition, metabolism and oncology to investigate disease prevention and treatment using both lifestyle changes and pharmacological interventions.

The series aims to address the complex nature of these disorders by looking at the links between metabolism, lifestyle and disease. It combines research and reviews published in Nutrition & Metabolism, Diabetology & Metabolic Syndrome, Nutrition Journal, Cardiovascular Diabetology, Journal of Experimental & Clinical Cancer Research, Journal of Translational Medicine (Nutrition & Metabolism Section), Molecular Cancer and Cancer and Metabolism. We welcome further submissions on this topic.

If you have a manuscript that you would like to be considered for the series please submit it via the online submission system for the relevant journal, and state clearly in the covering letter that it is intended for this thematic series. Before submitting your manuscript, please read the 'instructions for authors', for the relevant journal.

Collection published: 28 May 2012
Last updated: 7 March 2013

  1. Review

    Calorie restriction and cancer prevention: a mechanistic perspective

    Calorie restriction (CR) is one of the most potent broadly acting dietary interventions for inducing weight loss and for inhibiting cancer in experimental models. Translation of the mechanistic lessons learned...

    Stephen D Hursting, Sarah M Dunlap, Nikki A Ford, Marcie J Hursting and Laura M Lashinger

    Cancer & Metabolism 2013 1:10

    Published on: 7 March 2013

  2. Review

    Activated lymphocytes as a metabolic model for carcinogenesis

    Metabolic reprogramming is a key event in tumorigenesis to support cell growth, and cancer cells frequently become both highly glycolytic and glutamine dependent. Similarly, T lymphocytes (T cells) modify thei...

    Andrew N Macintyre and Jeffrey C Rathmell

    Cancer & Metabolism 2013 1:5

    Published on: 23 January 2013

  3. Research

    Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth

    Regulation of lipid metabolism via activation of sterol regulatory element binding proteins (SREBPs) has emerged as an important function of the Akt/mTORC1 signaling axis. Although the contribution of dysregul...

    Beatrice Griffiths, Caroline A Lewis, Karim Bensaad, Susana Ros, Qifeng Zhang, Emma C Ferber, Sofia Konisti, Barrie Peck, Heike Miess, Philip East, Michael Wakelam, Adrian L Harris and Almut Schulze

    Cancer & Metabolism 2013 1:3

    Published on: 23 January 2013

  4. Methodology

    Monitoring metabolic responses to chemotherapy in single cells and tumors using nanostructure-initiator mass spectrometry (NIMS) imaging

    Tissue imaging of treatment-induced metabolic changes is useful for optimizing cancer therapies, but commonly used methods require trade-offs between assay sensitivity and spatial resolution. Nanostructure-Ini...

    Peter J O’Brien, Michelle Lee, Mary E Spilker, Cathy C Zhang, Zhengming Yan, Timothy C Nichols, Wenlin Li, Caroline H Johnson, Gary J Patti and Gary Siuzdak

    Cancer & Metabolism 2013 1:4

    Published on: 23 January 2013

  5. Research

    Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma

    While aerobic glycolysis is linked to unconstrained proliferation in cancer, less is known about its physiological role. Why this metabolic program that promotes tumor growth is preserved in the genome has thu...

    Timothy R Gershon, Andrew J Crowther, Andrey Tikunov, Idoia Garcia, Ryan Annis, Hong Yuan, C Ryan Miller, Jeffrey Macdonald, James Olson and Mohanish Deshmukh

    Cancer & Metabolism 2013 1:2

    Published on: 23 January 2013

  6. Research

    A diet based on multiple functional concepts improves cardiometabolic risk parameters in healthy subjects

    Different foods can modulate cardiometabolic risk factors in persons already affected by metabolic alterations. The objective of this study was to assess, in healthy overweight individuals, the impact of a die...

    Juscelino Tovar, Anne Nilsson, Maria Johansson, Rickard Ekesbo, Ann-Margreth Åberg, Ulla Johansson and Inger Björck

    Nutrition & Metabolism 2012 9:29

    Published on: 2 April 2012

  7. Research

    Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro

    Obesity is associated with prostate cancer aggressiveness and mortality. The contribution of periprostatic adipose tissue, which is often infiltrated by malignant cells, to cancer progression is largely unknow...

    Ricardo Ribeiro, Cátia Monteiro, Virgínia Cunha, Maria José Oliveira, Mariana Freitas, Avelino Fraga, Paulo Príncipe, Carlos Lobato, Francisco Lobo, António Morais, Vítor Silva, José Sanches-Magalhães, Jorge Oliveira, Francisco Pina, Anabela Mota-Pinto, Carlos Lopes…

    Journal of Experimental & Clinical Cancer Research 2012 31:32

    Published on: 2 April 2012

  8. Review

    The mechanisms by which polyamines accelerate tumor spread

    Increased polyamine concentrations in the blood and urine of cancer patients reflect the enhanced levels of polyamine synthesis in cancer tissues arising from increased activity of enzymes responsible for poly...

    Kuniyasu Soda

    Journal of Experimental & Clinical Cancer Research 2011 30:95

    Published on: 11 October 2011

  9. Review

    Molecular targets and oxidative stress biomarkers in hepatocellular carcinoma: an overview

    Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor with multiple genetic aberrations. Several molecular pathways involved in the regulation of proliferation and cell death are implicated in th...

    Monica Marra, Ignazio M Sordelli, Angela Lombardi, Monica Lamberti, Luciano Tarantino, Aldo Giudice, Paola Stiuso, Alberto Abbruzzese, Rossella Sperlongano, Marina Accardo, Massimo Agresti, Michele Caraglia and Pasquale Sperlongano

    Journal of Translational Medicine 2011 9:171

    Published on: 10 October 2011

  10. Review

    Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings

    Considerable interest has been shown in the ability of caloric restriction (CR) to improve multiple parameters of health and to extend lifespan. CR is the reduction of caloric intake - typically by 20 - 40% of ad...

    John F Trepanowski, Robert E Canale, Kate E Marshall, Mohammad M Kabir and Richard J Bloomer

    Nutrition Journal 2011 10:107

    Published on: 7 October 2011

  11. Review

    Visceral adiposity, insulin resistance and cancer risk

    There is a well established link between obesity and cancer. Emerging research is characterising this relationship further and delineating the specific role of excess visceral adiposity, as opposed to simple o...

    Claire L Donohoe, Suzanne L Doyle and John V Reynolds

    Diabetology & Metabolic Syndrome 2011 3:12

    Published on: 22 June 2011

  12. Review

    The metabolic advantage of tumor cells

    Oncogenes express proteins of "Tyrosine kinase receptor pathways", a receptor family including insulin or IGF...

    Maurice Israël and Laurent Schwartz

    Molecular Cancer 2011 10:70

    Published on: 7 June 2011

  13. Review

    Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties

    Diabetes mellitus has emerged as one of the main alarms to human health in the 21st century. Pronounced changes in the human environment, behavior and lifestyle have accompanied globalization, which resulted i...

    Edite Teixeira-Lemos, Sara Nunes, Frederico Teixeira and Flávio Reis

    Cardiovascular Diabetology 2011 10:12

    Published on: 28 January 2011