Nutrition & Metabolism is calling for submissions to our collection on Nutrition, metabolism and brain health. Advancing age is associated with a decline in cognitive function and an increased risk factor of neurodegenerative diseases including Alzheimer’s disease and other dementias. As the average age of the worldwide population increases, more individuals will be affected by age-related cognitive decline and dementia, placing a substantial burden on public health services. Appropriate nutrition can positively impact brain health, slowing the rate of cognitive decline and reducing dementia risk with advancing age. However, more research is needed to understand the specific nutrients, foods, and healthy dietary patterns that can positively impact brain health. Similarly, additional mechanistic studies are warranted to elucidate the mechanisms through which nutrition can impact the brain. In addition, randomized clinical trials to determine which nutrients are beneficial in reducing age-related cognitive decline are needed to establish the importance of nutrition in brain health. In this collection of articles, we welcome research which provides new insight into the impact, and mechanisms of action, of nutrition on brain health, including (but not restricted to): cellular and animal model investigations, intervention studies with human participants, population-level epidemiological analyses, and systematic reviews and meta-analyses. We particularly welcome articles which focus on links between nutrition, metabolism, and brain health, given the strong links between metabolic alterations and the initiation and progression of neurodegenerative diseases.