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10 years of Nutrition & Metabolism

Nutrition & Metabolism has grown considerably in the ten years since its first article was published. To see how papers published in the journal had an impact we have identified some of the most popular articles in order to measure their influence, observe which fields are important to our readers, and try to explain what made these articles Nutrition & Metabolism “Classics”.

Collection published in Nutrition & Metabolism: 7 May 2014

  1. Review

    Cancer as a metabolic disease

    Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most...

    Thomas N Seyfried and Laura M Shelton

    Nutrition & Metabolism 2010 7:7

    Published on: 27 January 2010

  2. Research

    The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus

    Dietary carbohydrate is the major determinant of postprandial glucose levels, and several clinical studies have shown that low-carbohydrate diets improve glycemic control. In this study, we tested the hypothes...

    Eric C Westman, William S Yancy, John C Mavropoulos, Megan Marquart and Jennifer R McDuffie

    Nutrition & Metabolism 2008 5:36

    Published on: 19 December 2008

  3. Review

    Dietary carbohydrate restriction in type 2 diabetes mellitus and metabolic syndrome: time for a critical appraisal

    Current nutritional approaches to metabolic syndrome and type 2 diabetes generally rely on reductions in dietary fat. The success of such approaches has been limited and therapy more generally relies on pharma...

    Anthony Accurso, Richard K Bernstein, Annika Dahlqvist, Boris Draznin, Richard D Feinman, Eugene J Fine, Amy Gleed, David B Jacobs, Gabriel Larson, Robert H Lustig, Anssi H Manninen, Samy I McFarlane, Katharine Morrison, Jørgen Vesti Nielsen, Uffe Ravnskov, Karl S Roth…

    Nutrition & Metabolism 2008 5:9

    Published on: 8 April 2008

  4. Review

    Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review

    The leucine metabolite beta-hydroxy-beta-methylbutyrate (HMB) has been extensively used as an ergogenic aid; particularly among bodybuilders and strength/power athletes, who use it to promote exercise performa...

    Gabriel J Wilson, Jacob M Wilson and Anssi H Manninen

    Nutrition & Metabolism 2008 5:1

    Published on: 3 January 2008

  5. Research

    The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer

    Malignant brain cancer persists as a major disease of morbidity and mortality in adults and is the second leading cause of cancer death in children. Many current therapies for malignant brain tumors fail to pr...

    Weihua Zhou, Purna Mukherjee, Michael A Kiebish, William T Markis, John G Mantis and Thomas N Seyfried

    Nutrition & Metabolism 2007 4:5

    Published on: 21 February 2007

  6. Research

    AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model

    Obesity is one of the principal causative factors involved in the development of metabolic syndrome. AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular metabolism. The role of AMP-...

    Shailendra Giri, Ramandeep Rattan, Ehtishamul Haq, Mushfiquddin Khan, Rifat Yasmin, Je-song Won, Lyndon Key, Avtar K Singh and Inderjit Singh

    Nutrition & Metabolism 2006 3:31

    Published on: 10 August 2006

  7. Research

    Comparison of isocaloric very low carbohydrate/high saturated fat and high carbohydrate/low saturated fat diets on body composition and cardiovascular risk

    It is speculated that high saturated fat very low carbohydrate diets (VLCARB) have adverse effects on cardiovascular risk but evidence for this in controlled studies is lacking. The objective of this study was...

    Manny Noakes, Paul R Foster, Jennifer B Keogh, Anthony P James, John C Mamo and Peter M Clifton

    Nutrition & Metabolism 2006 3:7

    Published on: 11 January 2006

  8. Review

    Chocolate and Prevention of Cardiovascular Disease: A Systematic Review

    Consumption of chocolate has been often hypothesized to reduce the risk of cardiovascular disease (CVD) due to chocolate's high levels of stearic acid and antioxidant flavonoids. However, debate still lingers ...

    Eric L Ding, Susan M Hutfless, Xin Ding and Saket Girotra

    Nutrition & Metabolism 2006 3:2

    Published on: 3 January 2006

  9. Research

    A low-carbohydrate, ketogenic diet to treat type 2 diabetes

    The low-carbohydrate, ketogenic diet (LCKD) may be effective for improving glycemia and reducing medications in patients with type 2 diabetes.

    William S Yancy, Marjorie Foy, Allison M Chalecki, Mary C Vernon and Eric C Westman

    Nutrition & Metabolism 2005 2:34

    Published on: 1 December 2005

  10. Review

    Dietary protein intake and renal function

    Recent trends in weight loss diets have led to a substantial increase in protein intake by individuals. As a result, the safety of habitually consuming dietary protein in excess of recommended intakes has been...

    William F Martin, Lawrence E Armstrong and Nancy R Rodriguez

    Nutrition & Metabolism 2005 2:25

    Published on: 20 September 2005

  11. Review

    Fructose, insulin resistance, and metabolic dyslipidemia

    Obesity and type 2 diabetes are occurring at epidemic rates in the United States and many parts of the world. The "obesity epidemic" appears to have emerged largely from changes in our diet and reduced physica...

    Heather Basciano, Lisa Federico and Khosrow Adeli

    Nutrition & Metabolism 2005 2:5

    Published on: 21 February 2005

  12. Review

    Diet induced thermogenesis

    Daily energy expenditure consists of three components: basal metabolic rate, diet-induced thermogenesis and the energy cost of physical activity. Here, data on diet-induced thermogenesis are reviewed in relati...

    Klaas R Westerterp

    Nutrition & Metabolism 2004 1:5

    Published on: 18 August 2004

  13. Review

    Ketogenic diets and physical performance

    Impaired physical performance is a common but not obligate result of a low carbohydrate diet. Lessons from traditional Inuit culture indicate that time for adaptation, optimized sodium and potassium nutriture,...

    Stephen D Phinney

    Nutrition & Metabolism 2004 1:2

    Published on: 17 August 2004

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