Genome Medicine is pleased to present the Collection "Neurogenomics, from the bench to the clinic”. This issue will capture advances in the interpretation and application of genomic technologies and the understanding of genetic variation in the prevention, diagnosis and treatment of brain disorders, with a focus on neurodevelopmental, neuropsychiatric and neurodegenerative diseases. Of particular interest will be issues informing ancestral diversity in research and practice; advances in application of genomic technologies, such as single cell genomics, genetic and genomic biomarkers; the clinical utility of novel risk factors, including polygenic scores and the design of novel therapies; as well as the use of genetic and genomic profiling in clinical trial recruitment and monitoring the effects of treatment in trials.
In this Collection, guest edited by Dr Daniel Geschwind and Dr Jessica Rexach, we aim to highlight the advances in understanding disease pathophysiology that can inform how neurological and neuropsychiatric disorders are diagnosed and treated. We are inviting the submission of Research, Method, Software and Guideline manuscripts with significant clinical or translational impact, in all areas of neurological disease, including:
- Genetic and clinical heterogeneity
- Ancestry diversity
- Multimodal analyses in patient tissue and in clinical management, including single nucleus, single-cell, lrWGS
- Practice challenges for implementing clinical practices of genetic testing in clinical practice (such as variable insurance coverage for clinical genetic testing)
- Human model systems, including IPSC and humanized mice
- Drug discovery and therapies
- Clinical trials
- Precision medicine
- Community-driven data-sharing
We encourage work that fosters collaboration among scientists from multi-disciplinary fields and academic-industry partnerships.
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