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Neuroinflammation in the Retina

Edited by:
Thomas Langmann: University of Cologne, Germany
Przemyslaw (Mike) Sapieha: University of Montreal, Canada

Submission Status: Open   |   Submission Deadline: 30 April 2024


Journal of Neuroinflammation is calling for submissions to our new Collection on "Neuroinflammation in the Retina".



Image credit: Prof. Langmann

About the collection

Retinal degenerative and neovascular diseases, including age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma and rare monogenic dystrophies are major causes for global severe vision loss or blindness. In recent years, neuroinflammatory mechanisms have been identified as major factors for triggering the onset and progression of all these retinal diseases. Loss of retinal immune homeostasis is often accompanied by profound changes in cellular and humoral innate immunity and also involves adaptive immune responses by invading blood cell populations. We are only just beginning to understand the complex ocular inflammatory mechanisms and interplay between immune cells that occur in the eyes of patients with visual impairment.

This Collection seeks to discover novel immune mechanisms in the diseased retina that may offer novel diagnostic markers or highlight targets for immuno-modulatory therapies that could help to reduce the burden of vision loss worldwide.

As part of this Collection, we invite articles that cover the following topics:

• Role of resident and invading mononuclear phagocytes in the retina
• Role of T-cells and B-cells in retinal disease
• Complement factors in retinal disease
• Retinal pigment epithelium (RPE) inflammasome
• Immune responses in retinal gene therapy
• Microbiome and retinal immunity
• Retinal Immune memory and epigenetics
• Cellular senescence and retinal immune system
• Microglia-glia interactions in the retina

  1. Inherited, age-related, and acute retinal diseases are often exacerbated by an aberrant or excessive activity of the complement system. Consequently, cells not directly affected by an acute event or genetic va...

    Authors: Josef Biber, Yassin Jabri, Sarah Glänzer, Aaron Dort, Patricia Hoffelner, Christoph Q. Schmidt, Oliver Bludau, Diana Pauly and Antje Grosche
    Citation: Journal of Neuroinflammation 2024 21:56
  2. Glaucoma is a complex neurodegenerative disorder characterized by the progressive loss of retinal ganglion cells (RGC) and optic nerve axons, leading to irreversible visual impairment. Despite its clinical sig...

    Authors: Chong He, Kun Peng, Xiong Zhu, Zuo Wang, Wenbo Xiu, Gao Zhang, Yang Chen, Chaonan Sun, Xiao Xiao, Donghua Liu, An Li, Yanping Gao, Jinxia Wang, Ping Shuai, Yilian Chen, Ling Yu…
    Citation: Journal of Neuroinflammation 2024 21:43
  3. Diabetic retinopathy (DR) affects about 200 million people worldwide, causing leakage of blood components into retinal tissues, leading to activation of microglia, the resident phagocytes of the retina, promot...

    Authors: Derek Rodriguez, Kaira A. Church, Alicia N. Pietramale, Sandra M. Cardona, Difernando Vanegas, Colin Rorex, Micah C. Leary, Isabel A. Muzzio, Kevin R. Nash and Astrid E. Cardona
    Citation: Journal of Neuroinflammation 2024 21:42
  4. Pathological neovascularization is a pivotal biological process in wet age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and proliferative diabetic retinopathy (PDR), in which macrophage...

    Authors: Tianyi Shen, Ruoyi Lin, Chengyu Hu, Donghui Yu, Chengda Ren, Tingting Li, Meijiang Zhu, Zhongqi Wan, Tu Su, Yan Wu, Wenting Cai and Jing Yu
    Citation: Journal of Neuroinflammation 2023 20:308
  5. Neuroinflammation and mitochondrial dysfunction play crucial roles in retinal ischemia and reperfusion (IR) injury. Recent studies have identified mitochondrial function as a promising target for immunomodulat...

    Authors: Zhenlan Yang, Yidan Liu, Xuhao Chen, Shaofen Huang, Yangyang Li, Guitong Ye, Xu Cao, Wenru Su and Yehong Zhuo
    Citation: Journal of Neuroinflammation 2023 20:296
  6. Vision loss in patients with wet/exudative age-related macular degeneration (AMD) is associated with choroidal neovascularization (CNV), and AMD is the leading cause of irreversible vision impairment in older ...

    Authors: Yu-Hsien Chang, Chung-Hsi Hsing, Chiao-Juno Chiu, Yi-Rou Wu, Sheng-Min Hsu and Yu-Hsiang Hsu
    Citation: Journal of Neuroinflammation 2023 20:279
  7. Neovascular age-related macular degeneration causes vision loss from destructive angiogenesis, termed choroidal neovascularization (CNV). Cx3cr1−/− mice display alterations in non-classical monocytes and microgli...

    Authors: Steven Droho, Andrew P. Voigt, Jacob K. Sterling, Amrita Rajesh, Kyle S. Chan, Carla M. Cuda, Harris Perlman and Jeremy A. Lavine
    Citation: Journal of Neuroinflammation 2023 20:238

Submission Guidelines

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This Collection welcomes submission of original Research Articles and Reviews. Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal. Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select "Neuroinflammation in the Retina" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests.