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Neurocritical care

Edited by Fabio Silvo Taccone

Adequate treatment of patients with acute brain injury aims to optimize cerebral perfusion as to minimize the occurrence of secondary injuries. However, several questions on the optimal management still remain unanswered. In this review series published in Critical Care, the appropriate use of sedative and analgesic agents will be discussed; indeed, sedation may provide some neuroprotection in the most severe patients but it should be also interrupted to allow clinical daily examination. Similarly, the best approach to guide fluid administration and blood transfusion will be accurately examined. The important issue of the regulation and bedside assessment of cerebral circulation may provide significant proposals in order to avoid cerebral hypoperfusion in these patients. Finally, the management of cerebral vasospasm after subarachnoid haemorrhage, which remains one of the main causes of poor neurological outcome, will be discussed.

  1. Intracranial hypertension (ICH) is a major cause of death after traumatic brain injury (TBI). Continuous hyperosmolar therapy (CHT) has been proposed for the treatment of ICH, but its effectiveness is controve...

    Authors: Karim Asehnoune, Sigismond Lasocki, Philippe Seguin, Thomas Geeraerts, Pierre François Perrigault, Claire Dahyot-Fizelier, Catherine Paugam Burtz, Fabrice Cook, Dominique Demeure dit latte, Raphael Cinotti, Pierre Joachim Mahe, Camille Fortuit, Romain Pirracchio, Fanny Feuillet, Véronique Sébille and Antoine Roquilly
    Citation: Critical Care 2017 21:328

    The Editorial to this article has been published in Critical Care 2018 22:37

  2. Anemia is frequent among brain-injured patients, where it has been associated with an increased risk of poor outcome. The pathophysiology of anemia in this patient population remains multifactorial; moreover, ...

    Authors: Christophe Lelubre, Pierre Bouzat, Ilaria Alice Crippa and Fabio Silvio Taccone
    Citation: Critical Care 2016 20:152
  3. Daily interruption of sedative therapy and limitation of deep sedation have been shown in several randomized trials to reduce the duration of mechanical ventilation and hospital length of stay, and to improve ...

    Authors: Mauro Oddo, Ilaria Alice Crippa, Sangeeta Mehta, David Menon, Jean-Francois Payen, Fabio Silvio Taccone and Giuseppe Citerio
    Citation: Critical Care 2016 20:128