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Neuroimmunology and Ageing

Topical Collection for Immunity & Ageing: Neuroimmunology and Ageing by Moisés E. Bauer (PUCRS, Brazil) and Roberto Paganelli (Università degli Studi G. d'Annunzio Chieti e Pescara, Italy).

This topical collection will explore how complex neuroimmune interactions promote healthy and pathological ageing. We seek reviews, viewpoints, commentaries, or original research articles exploring the role of stress, mood disorders, and sensory systems during normal and premature immunosenescence. Over the last few decades, increasing evidence is implicating a role for the immune system in brain physiology and behaviour. Therefore, we also welcome articles discussing the role of immune cells and cytokines for the ageing brain, as well as the role of inflammation in neuromuscular disorders associated with senescence. In addition, we seek articles exploring the role of immunosenescence in age-related pathologies of the nervous system, including neurodegenerative and autoimmune disorders (e.g., AD, PD and MS), as well as the role of vascular disease in neurodegeneration. In the context of the COVID-19 pandemic, we also seek articles discussing post-infectious degeneration in older adults.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process.

Please find out more about our journal and its policies, here. Submission guidelines can be found here.

This collection is no longer accepting submissions.


  1. Exercise is postulated to be a promising non-pharmacological intervention for the improvement of neurodegenerative disease pathology. However, the mechanism of beneficial effects of exercise on the brain remai...

    Authors: Hao Han, Yawei Zhao, Junda Du, Sushan Wang, Xuehan Yang, Weijie Li, Jiayi Song, Siwei Zhang, Ziyi Zhang, Yongfei Tan, Grant M. Hatch, Ming Zhang and Li Chen
    Citation: Immunity & Ageing 2023 20:63
    Content type: Research Published on:

  2. The involvement of the peripheral immune system in the etiology of neurodegenerative diseases has recently been emphasized. Genome-wide association studies (GWAS) have recently identified several candidate imm...

    Authors: S. R. Fatemi Langroudi, M. Zeinaly and F. Ajamian
    Citation: Immunity & Ageing 2023 20:59
    Content type: Research Published on:

  3. More and more evidences are proving that microglia play a crucial role in the pathogenesis of Alzheimer’s disease (AD) and the plasma Aβ1-42 levels significantly increased 15 years before the onset of dominantly ...

    Authors: Chunrong Li, Kangding Liu, Jie Zhu and Feiqi Zhu
    Citation: Immunity & Ageing 2023 20:39
    Content type: Research Published on:

  4. TDP-43 is an important DNA/RNA-binding protein that is associated with age-related neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD); however, its pathome...

    Authors: Wenkai Yue, Xue Deng, Zhao Wang, Mingsheng Jiang, Rirong Hu, Yongjia Duan, Qiangqiang Wang, Jihong Cui and Yanshan Fang
    Citation: Immunity & Ageing 2023 20:27
    Content type: Brief Report Published on:

  5. Pain in Fabry disease (FD) is generally accepted to result from neuronal damage in the peripheral nervous system as a consequence of excess lipid storage caused by alpha-galactosidase A (α-Gal A) deficiency. S...

    Authors: Jeiny Luna Choconta, Verena Labi, Cristiana Dumbraveanu, Theodora Kalpachidou, Kai K. Kummer and Michaela Kress
    Citation: Immunity & Ageing 2023 20:22
    Content type: Research Published on:

  6. Advanced age is one of the significant risk determinants for coronavirus disease 2019 (COVID-19)-related mortality and for long COVID complications. The contributing factors may include the age-related dynamic...

    Authors: Ludmila Müller and Svetlana Di Benedetto
    Citation: Immunity & Ageing 2023 20:17
    Content type: Review Published on:

  7. Natural antibodies (nAbs) against aggregation-prone proteins have been found in healthy normal subjects. These proteins likely have a pathogenetic role in neurodegenerative diseases of ageing. They include the...

    Authors: Roberto Paganelli, Alessia Paganelli, Graham Pawelec and Angelo Di Iorio
    Citation: Immunity & Ageing 2023 20:13
    Content type: Brief Report Published on:

  8. Glycyrrhizic acid (GA), a saponin compound often used as a flavoring agent, can elicit anti-inflammatory and anti-tumor effects, and alleviate aging. However, the specific mechanism by which GA alters immune c...

    Authors: Xue Gong, Haitao Shen, Liuling Guo, Ce Huang, Tingting Su, Hao Wang, Shengyu Feng, Shanshan Yang, Fenjiao Huo, Haifeng Liu, Jianbo Zhu, Jian-Kang Zhu, Hongbin Li and Hailiang Liu
    Citation: Immunity & Ageing 2023 20:12
    Content type: Research Published on:

  9. There is increasing concern that cancer and cancer treatment accelerate aging and the associated cognitive decline. We showed recently that treatment of 9-month-old male mice with cisplatin causes cognitive de...

    Authors: Miriam Zamorano, Jenolyn F. Alexander, Desiree Catania, Shruti Dharmaraj, Annemieke Kavelaars and Cobi J. Heijnen
    Citation: Immunity & Ageing 2023 20:5
    Content type: Research Published on:

  10. The diffuse distribution of nicotinic cholinergic receptors (nAChRs) in both brain and peripheral immune cells points out their involvement in several pathological conditions. Indeed, the deregulated function ...

    Authors: E. Costantini, C. Carrarini, P. Borrelli, M. De Rosa, D. Calisi, S. Consoli, D. D’Ardes, F. Cipollone, M. Di Nicola, M. Onofrj, M. Reale and L. Bonanni
    Citation: Immunity & Ageing 2023 20:3
    Content type: Research Published on:

  11. Diet and chronic inflammation might play a major role in the pathogenesis of mild cognitive impairment (MCI). In addition, peripheral blood leukocyte telomere length (LTL) and mitochondrial DNA copy number (mt...

    Authors: Qian Liu, Zhenshu Li, Ling Huang, Dezheng Zhou, Jingzhu Fu, Huilian Duan, Zehao Wang, Tong Yang, Jing Zhao, Wen Li, Huan Liu, Fei Ma, Changqing Sun, Guangshun Wang, Yue Du, Meilin Zhang…
    Citation: Immunity & Ageing 2023 20:1
    Content type: Research Published on:

  12. Obesity rates are increasing worldwide. Obesity leads to many complications, including predisposing individuals to the development of cognitive impairment as they age. Immune dysregulation, including inflammag...

    Authors: Rosemary E. Henn, Sarah E. Elzinga, Emily Glass, Rachel Parent, Kai Guo, Adam A. Allouch, Faye E. Mendelson, John Hayes, Ian Webber-Davis, Geoffery G. Murphy, Junguk Hur and Eva L. Feldman
    Citation: Immunity & Ageing 2022 19:67
    Content type: Research Published on:

  14. Cognitive symptoms of major depressive disorder, such as negative cognitive bias, are more prevalent in women than in men. Cognitive bias involves pattern separation which requires hippocampal neurogenesis and...

    Authors: Travis E. Hodges, Stephanie E. Lieblich, Rebecca K. Rechlin and Liisa A. M. Galea
    Citation: Immunity & Ageing 2022 19:43
    Content type: Research Published on:

  16. The immune cell compartment of the mammalian brain changes dramatically and peripheral T cells infiltrate the brain parenchyma during normal aging. However, the mechanisms underlying age-related T cell infiltr...

    Authors: Xiaotao Zhang, Rui Wang, Haoran Chen, Chenghao Jin, Ziyang Jin, Jianan Lu, Liang Xu, Yunrong Lu, Jianmin Zhang and Ligen Shi
    Citation: Immunity & Ageing 2022 19:34
    Content type: Research Published on:

  18. Understanding mechanisms of pathologic neuroinflammation is essential for improving outcomes after central nervous system infections. Brain tissue-resident memory T cells (bTRM) are recruited during central nervo...

    Authors: Benjamin R. Cassidy, William E. Sonntag, Pieter J. M. Leenen and Douglas A. Drevets
    Citation: Immunity & Ageing 2022 19:25
    Content type: Research Published on:

  19. Depression is considered to be an immune-related disease; however, previous studies have focused on inflammatory factors, and there is no conclusive conclusion on the relationships between immunoglobulins and ...

    Authors: Zhigao Sun, Jieqiong Lin, Yujie Zhang, Yao Yao, Zhenjun Huang, Yali Zhao, Pei Zhang and Shihui Fu
    Citation: Immunity & Ageing 2022 19:21
    Content type: Brief Report Published on: