Skip to main content


Microvesicles and Tumor Microenvironment in Cancer Development and Resistance to Therapies

The tumor microenvironment (TME) has an effect on tumor development, growth, and resistance to therapy. Continuous interactions and exchanges between tumor cells and the TME are involved in angiogenesis, tumor genetic diversity, immune escape, and metastasis.   
Developed and published by Molecular Cancer, this series aims to highlight significant findings and advances in our understanding of the role of the TME in cancer biology. 

  1. Content type: Review

    Neddylation, a post-translational modification that adds an ubiquitin-like protein NEDD8 to substrate proteins, modulates many important biological processes, including tumorigenesis. The process of protein ne...

    Authors: Lisha Zhou, Yanyu Jiang, Qin Luo, Lihui Li and Lijun Jia

    Citation: Molecular Cancer 2019 18:77

    Published on:

  2. Content type: Research

    Cisplatin (CDDP) treatment is one of the most predominant chemotherapeutic strategies for patients with gastric cancer (GC). A better understanding of the mechanisms of CDDP resistance can greatly improve ther...

    Authors: Xiaoxu Huang, Zheng Li, Qiang Zhang, Weizhi Wang, Bowen Li, Lu Wang, Zhipeng Xu, Ailiang Zeng, Xing Zhang, Xuan Zhang, Zhongyuan He, Qiang Li, Guangli Sun, Sen Wang, Qing Li, Linjun Wang…

    Citation: Molecular Cancer 2019 18:71

    Published on:

  3. Content type: Review

    In the last decades, the role of the microenvironment in tumor progression and therapeutic outcome has gained increasing attention. Cancer-associated fibroblasts (CAFs) have emerged as key players among stroma...

    Authors: Micol Eleonora Fiori, Simone Di Franco, Lidia Villanova, Paola Bianca, Giorgio Stassi and Ruggero De Maria

    Citation: Molecular Cancer 2019 18:70

    Published on:

  4. Content type: Research

    Although the tumor stroma in solid tumors like gastric cancer (GC) plays a crucial role in chemo-resistance, specific targets to inhibit the interaction between the stromal and cancer cells have not yet been u...

    Authors: In-Hye Ham, Hye Jeong Oh, Hyejin Jin, Cheong A Bae, Sang-Min Jeon, Kyeong Sook Choi, Sang-Yong Son, Sang-Uk Han, Rolf A. Brekken, Dakeun Lee and Hoon Hur

    Citation: Molecular Cancer 2019 18:68

    Published on:

  5. Content type: Review

    Although solid tumors comprise malignant cells, they also contain many different non-malignant cell types in their micro-environment. The cellular components of the tumor stroma consist of immune and endotheli...

    Authors: Jana Plava, Marina Cihova, Monika Burikova, Miroslava Matuskova, Lucia Kucerova and Svetlana Miklikova

    Citation: Molecular Cancer 2019 18:67

    Published on:

  6. Content type: Review

    The intestinal epithelial lining is one of the most rapidly renewing cell populations in the body. As a result, the gut has been an attractive model to resolve key mechanisms in epithelial homeostasis. In part...

    Authors: Maartje van der Heijden and Louis Vermeulen

    Citation: Molecular Cancer 2019 18:66

    Published on:

  7. Content type: Research

    Tumor-associated macrophages (TAMs) are major components of tumor microenvironment that frequently associated with tumor metastasis in human cancers. Circulating tumor cell (CTC), originating from primary tumo...

    Authors: Chen Wei, Chaogang Yang, Shuyi Wang, Dongdong Shi, Chunxiao Zhang, Xiaobin Lin, Qing Liu, Rongzhang Dou and Bin Xiong

    Citation: Molecular Cancer 2019 18:64

    Published on:

  8. Content type: Review

    The tumor microenvironment (TME) is comprised of many different cell populations, such as cancer-associated fibroblasts and various infiltrating immune cells, and non-cell components of extracellular matrix. T...

    Authors: Barbora Peltanova, Martina Raudenska and Michal Masarik

    Citation: Molecular Cancer 2019 18:63

    Published on:

  9. Content type: Review

    Gastric cancer (GC) is one of the leading causes of cancer-related death in both men and women due to delayed diagnosis and high metastatic frequency. Extracellular vesicles (EVs) are membrane-bound nanovesicl...

    Authors: Tingting Huang, Chunli Song, Lei Zheng, Ligang Xia, Yang Li and Yiwen Zhou

    Citation: Molecular Cancer 2019 18:62

    Published on:

  10. Content type: Research

    Myeloid-derived suppressor cells (MDSCs) participate in tumor-elicited immunosuppression by dramatically blocking T-cell-induced antitumor responses, thereby influencing the effectiveness of cancer immunothera...

    Authors: Yu Zheng, Xinyu Tian, Tingting Wang, Xueli Xia, Fenghua Cao, Jie Tian, Ping Xu, Jie Ma, Huaxi Xu and Shengjun Wang

    Citation: Molecular Cancer 2019 18:61

    Published on:

  11. Content type: Review

    Therapy resistance can arise within tumor cells because of genetic or phenotypic changes (intrinsic resistance), or it can be the result of an interaction with the tumor microenvironment (extrinsic resistance)...

    Authors: Teresa Bernadette Steinbichler, József Dudás, Sergej Skvortsov, Ute Ganswindt, Herbert Riechelmann and Ira-Ida Skvortsova

    Citation: Molecular Cancer 2019 18:58

    Published on:

  12. Content type: Review

    Hypoxic tumor microenvironment is a common feature of solid tumors and is associated with aggressiveness and poor patient outcomes. A continuous interference between cancer cells and stromal cells within the h...

    Authors: Wanrong Meng, Yaying Hao, Chuanshi He, Ling Li and Guiquan Zhu

    Citation: Molecular Cancer 2019 18:57

    Published on:

  13. Content type: Review

    CircRNAs, as new members of long noncoding RNAs, have been the focus of recent investigation. CircRNAs feature a closed continuous loop structure without 5′-3′ polarity or a poly A tail. Many studies have repo...

    Authors: Hetian Bai, Kexin Lei, Fei Huang, Zhou Jiang and Xikun Zhou

    Citation: Molecular Cancer 2019 18:56

    Published on:

  14. Content type: Review

    The tumor microenvironment represents a complex network, in which tumor cells not only communicate with each other but also with stromal and immune cells. Current research has demonstrated the vital role of th...

    Authors: Selma Maacha, Ajaz A. Bhat, Lizandra Jimenez, Afsheen Raza, Mohammad Haris, Shahab Uddin and Jean-Charles Grivel

    Citation: Molecular Cancer 2019 18:55

    Published on:

  15. Content type: Research

    MicroRNAs (miRs) are involved in lymphoma progression by regulating tumor cell interaction with microenvironment. MiR155 is overexpressed in diffuse large B-cell lymphoma (DLBCL) and its biological effect on t...

    Authors: Zhong Zheng, Rui Sun, Hui-Jin Zhao, Di Fu, Hui-Juan Zhong, Xiang-Qin Weng, Bin Qu, Yan Zhao, Li Wang and Wei-Li Zhao

    Citation: Molecular Cancer 2019 18:54

    Published on:

  16. Content type: Review

    Intercellular communication between cellular compartments within the tumor and at distant sites is critical for the development and progression of cancer. Exosomes have emerged as potential regulators of intra...

    Authors: Kathleen M. McAndrews and Raghu Kalluri

    Citation: Molecular Cancer 2019 18:52

    Published on:

  17. Content type: Review

    The tumor microenvironment is a complex and dynamic cellular community comprising the tumor epithelium and various tumor-supporting cells such as immune cells, fibroblasts, immunosuppressive cells, adipose cel...

    Authors: Hong Sheng Cheng, Jeannie Xue Ting Lee, Walter Wahli and Nguan Soon Tan

    Citation: Molecular Cancer 2019 18:51

    Published on:

  18. Content type: Review

    Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression. Microvesicles (MVs) ...

    Authors: Xiaojie Bian, Yu-Tian Xiao, Tianqi Wu, Mengfei Yao, Leilei Du, Shancheng Ren and Jianhua Wang

    Citation: Molecular Cancer 2019 18:50

    Published on:

  19. Content type: Review

    Cells respond to hypoxia by shifting cellular processes from general housekeeping functions to activating specialized hypoxia-response pathways. Oxygen plays an important role in generating ATP to maintain a p...

    Authors: Nancy T. Chee, Ines Lohse and Shaun P. Brothers

    Citation: Molecular Cancer 2019 18:49

    Published on:

  20. Content type: Review

    Among all the deadly cancers, pancreatic cancer ranks seventh in mortality. The absence of any grave symptoms coupled with the unavailability of early prognostic and diagnostic markers make the disease incurab...

    Authors: Manendra Babu Lankadasari, Pramiti Mukhopadhyay, Sabira Mohammed and Kuzhuvelil B. Harikumar

    Citation: Molecular Cancer 2019 18:48

    Published on: