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Multi-omics approaches to unravel gene-environmental interactions in noncommunicable diseases

Guest Editors:
Tesfaye B. Mersha: Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, USA
Daniel Enquobahrie: University of Washington, USA

Submission Status: Open   |   Submission Deadline: 15 August 2024

Human Genomics is calling for submissions to our Collection on "Multi-omics approaches to unravel gene-environmental interactions in noncommunicable diseases". This Collection supports and amplifies research related to SDG 3 and SDG 10.

Image credit: JuSun / Getty Images / iStock

About the collection

Although individual -omics analysis such as genome-wide association studies (GWAS), can effectively map genetic variants correlated with noncommunicable diseases (NCDs), the majority of the heritability and the functional relevance of discovered variants are not explained or known by the identified variants. The limited success of singular approaches underscores the need for holistic and integrated approaches to investigate complex phenotypes using trans-omics data integration strategies. Integration of omics layers (e.g., genome, epigenome, transcriptome, proteome, metabolome, lipidome, exposome, microbiome), which often have complementary and synergistic effects, offer the opportunity to comprehensively understand the flow of information that underlines the biological basis of NCDs. To unravel the complexities of the genomic basis of human disease, and in particular the influence of the environment, it is imperative that we fully integrate multiple layers of genomic data. Gene-environment interactions play key roles in NCD pathogenesis. Therefore, better understanding of gene-environment interactions in NCDs can improve both clinical medicine and public health. However, significant gaps remain in defining and characterizing extent and mechanisms of gene-environment interactions in several NCDs. Importantly, evaluations of gene-environment interactions have lagged the fast discovery pace of characterizing genetic variations and improvements in exposure measurement due to limitations in methods. In addition, application of knowledge on gene-environment interactions towards improving human health, through translational research (e.g. precision medicine) has been limited. In this Collection, we aim to gather articles that address the broad area of gene-environment interactions in NCDs, with particular emphasis on articles that address gaps including multi-omics integration. 


The purpose of this Collection is to identify and describe developments, challenges and opportunities related to the integration of environmental exposure data with -omics data in population studies. 


• To understand the developments, challenges and opportunities in integrating environmental data with -omics.
• To identify the possible approaches and best practices for integration of multi-omics and environmental data.
• To identify special considerations for using environmental and multi-omic data for noncommunicable diseases.
• To determine how experimental models integrating environmental exposures and -omics data effects can be used to inform knowledge on noncommunicable diseases.
• To describe integration of environmental and -omics data in translational research to address noncommunicable diseases.

  1. Diabetes is a spectrum of metabolic diseases affecting millions of people worldwide. The loss of pancreatic β-cell mass by either autoimmune destruction or apoptosis, in type 1-diabetes (T1D) and type 2-diabet...

    Authors: M. I. Farrim, A. Gomes, D. Milenkovic and R. Menezes
    Citation: Human Genomics 2024 18:16

Submission Guidelines

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This Collection welcomes submission of original Research Articles and Reviews. Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal. Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select "Multi-omics approaches to unravel gene-environmental interactions in noncommunicable diseases" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests.